Phase 4 N=60 Thrombectomy REvascularization of Large Vessel Occlusions in Acute Ischemic Stroke (TREVO)
Ischemic Stroke
Primary: Revascularization Status — 92 percentage of subjects TICI 2 or >
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=80 Deep Learning Enabled Endovascular Stroke Therapy Screening in Community Hospitals
Acute Ischemic Stroke (AIS)
Primary: Time From Emergency Room Arrival to Initiation of Endovascular Stroke Therapy ("Door-to-groin" Time) — 100; 88 minutes
N/A N=352 SELECT2: A Randomized Controlled Trial to Optimize Patient's Selection for Endovascular Treatment in Acute Ischemic Stroke
Acute Ischemic Stroke
Primary: Degree of Disability/Dependence as Measured by the Modified Rankin Scale (mRS) Score — 4; 5 scores on a scale
N/A N=54 Post Marketing Study to Evaluate the NIMBUS Device
Cerebral Stroke
Primary: Percentage of Participants With Successful Revascularization With NIMBUS Device — 68.6 Percentage of participants
N/A N=198 A Randomized, Concurrent Controlled Trial to Assess the Safety and Effectiveness of the Separator 3D as a Component of the Penumbra System in the Revascularization of Large Vessel Occlusion in Acute Ischemic Stroke
Acute Ischemic Stroke From Large Vessel Occlusion
Primary: Number of Participants With Angiographic Revascularization of the Occluded Target Vessel — 82; 79 Participants
N/A N=228 Analysis of Revascularization in Ischemic Stroke With EmboTrap
Stroke · Ischemia
Primary: Successful Revascularization Measured Using Modified Thrombolysis in Cerebrovascular Infarction (mTICI Inclusive of the 2c Rating) — 182 Participants
N/A N=196 Solitaire™ With the Intention For Thrombectomy as PRIMary Endovascular Treatment (SWIFT PRIME) Trial
Acute Ischemic Stroke
Primary: 90-day Global Disability Assessed Via the Blinded Evaluation of Modified Rankin Score (mRS). — 17; 8; 25; 10 Participants
Phase 2 N=125 Study to Assess the Safety and Effectiveness of the Penumbra System
Stroke
Primary: Percentage of Participants With Revascularization of the Occluded Target Vessel — 81.2 Percentage of Participants
Phase 2 N=83 Safety of RNS60 in Large Vessel Occlusion Stroke Patients Undergoing Endovascular Thrombectomy
Stroke, Ischemic
Primary: Number of Participants With Serious Adverse Events (SAEs) — 6; 10; 8 Participants
Early Phase 1 N=453 Endovascular Recanalization and Standard Medical Management for Symptomatic Nonacute Intracranial Artery Occlusion Trial
Intracranial Artery Occlusion With Infarction
Primary: Primary Outcome — 27; 21 Participants
N/A N=102 Prospective Evaluation to Characterize the Real-World Performance of the EMBOVAC Aspiration Catheter
Acute Ischemic Stroke
Primary: Percentage of Participants With Successful Revascularization — 98.0 Percentage of participants
N/A N=160 Treatment With Intent to Generate Endovascular Reperfusion
Ischemic Stroke
Primary: Successful Reperfusion, Defined as mTICI Score ≥ 2b — 130 Participants
Phase 4 N=108 Assess the Penumbra System in the Treatment of Acute Stroke
Ischemic Stroke
Primary: Good Functional Outcome as Defined by a Modified Rankin Score of 0-2 — 14; 19 Participants
N/A N=1,492 ASSIST Registry Studying Various Operator Techniques
Ischemic Stroke
Primary: Percentage of Subjects Achieved Good Functional Outcome (mRS 0-2) at Day 90 — 140; 351; 273 Participants
Phase 3 N=363 LACunar Intervention (LACI-2) Trial-2
Cerebral Small Vessel Diseases · Stroke, Lacunar
Primary: Feasibility of Phase III Trial — 20; 21; 10; 4 Participants
N/A N=12,551 1-year Clinical Outcomes in Recombinant Tissue Plasminogen Activator (Rt-PA) Treated Chinese Acute Ischaemic Stroke (AIS) Patients
Stroke
Primary: All-cause Mortality at 1 Year (Percentage of Patients With Modified Rankin Scale (mRS) Score =6) — 11.1; 12.2 Percentage of Participants — p=0.183
N/A N=178 Randomized Trial Evaluating Performance of the Trevo Retriever Versus the Merci Retriever in Acute Ischemic Stroke
Ischemic Stroke
Primary: Primary Efficacy Endpoint — 54; 76 participants
N/A N=49 Reperfuse Ischemic Vessels With Endovascular Recanalization Device in JAPAN (RIVER JAPAN)
Acute Ischemic Stroke
Primary: Proportion of Patients Who Have Recanalization — 36 participants
N/A N=206 Clinical Mismatch in the Triage of Wake Up and Late Presenting Strokes Undergoing Neurointervention With Trevo
Ischemic Stroke
Primary: Weighted Modified Rankin Scale (mRS) Score, Lead Co-Primary Efficacy Outcome — 5.5; 3.4 score on a scale
N/A N=984 Systematic Evaluation of Patients Treated With Stroke Devices for Acute Ischemic Stroke (STRATIS) Registry
Ischemic Stroke
Primary: Number of Participants Assessed for Revascularization With mTICI Grades 2b-3 — 724 Participants
Phase 1 N=24 A Phase Ib/II in Patients With Acute Ischemic Stroke
Ischemic Stroke
Primary: Maximum Tolerated Dose (MTD) of DDFPe Evaluated by Number of Dose Limiting Toxicities — 0; 0; 0; 0 Dose Limiting Toxicities
N/A N=146 Imaging Guided Patient Selection for Interventional Revascularization Therapy
Acute Ischemic Stroke
Primary: Functional Outcome as Defined by a mRS of 0-2 at 90 Days Post-procedure — 57 Participants
Phase 3 N=458 Tenecteplase in Stroke Patients Between 4.5 and 24 Hours
THROMBOLYSIS
Primary: Ordinal Modified Rankin Scale (mRS) Score at Day 90 — 35; 31; 38; 30 Count of participants
N/A N=202 Solitaire FR Thrombectomy for Acute Revascularisation
Stroke, Acute
Primary: Arterial Recanalization of the Occluded Target Vessel Measured by Thrombolysis in Cerebral Infarction (TICI) Score Equal or Superior to 2b Following the Use of the Study…
N/A N=1,560 Alteplase Treatment in Elderly Acute Ischaemic Stroke (AIS) Patients
Stroke
Primary: Percentage of Patients With Favourable Outcome (Modified Rankin Scale (mRS) 0-1) at 1 Year — 27.7; 23.8 Percentage of Participants — p=<0.001
Phase 2 N=88 A Study to Evaluate the Safety and Efficacy of Multiple Doses of LT3001 Drug Product in AIS Subjects
Acute Ischemic Stroke
Primary: The Proportion of Subjects With Adverse Events (AEs), Judged to be Probably or Definitely Related to the Investigational Product (IP), Within 90 Days After the First IP…
Phase 2 N=40 Percutaneous Recanalization in Ischemic Stroke Management (PRIISM): A Feasibility Clinical Study
Ischemic Stroke
Primary: Technical Device Success by as Assessed by the Percentage of Participants Which Established at Least TIMI 2 Flow Upon Deployment of the System Across the Occlusion and…
N/A N=10 Transcranial Direct Current Stimulation as a Neuroprotection in Acute Stroke
Stroke, Acute
Primary: Safety Outcome: Rate of Symptomatic Intracranial Hemorrhage (SICH) in the Active Treatment Arms Compared to Sham Arm — 0; 1; 0 Participants
Phase 2 N=31 NeuroCognition After Carotid Recanalization
Cognition Disorder · Stroke · Occlusion Carotid
Primary: Change in Montreal Cognitive Assessment (MoCA) Score — 0.56; 1.38; -0.75; 0.50 score on a scale
Phase 2 N=118 Mechanical Retrieval and Recanalization of Stroke Clots Using Embolectomy
Stroke
Primary: The Modified Rankin Scale Score — 3.9; 3.4; 4.0; 4.4 units on a scale