N/A N=69 High Pain Intervention in Cesarean Sections
Other Chronic Postoperative Pain
Primary: Severity of Acute Pain — 46; 31 mm — p=0.05
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=393 Acetaminophen (APAP) +/- Oxycodone
Musculoskeletal Pain
Primary: Change in Pain Assessment — 2.9; 4.0 score on a scale
Phase 3 N=224 Protocolized vs Nonprotocolized Treatment of Adult ED Patients With Acute Severe Pain
Acute Pain
Primary: Patient Reported Change in Pain Intensity From Initial Administration of Analgesics (Baseline) to 60 Minutes Post-baseline. — 5.5; 4.5 units on a scale
Phase 4 N=159 IV Acetaminophen as an Analgesic Adjunct
Acute Pain
Primary: Change in Pain Intensity, Baseline to 60 Minutes After Medication Infused — 5.8; 5.2 units on a scale
Phase 2 N=162 Acetaminophen Versus IV Hydromorphone for Pain in the Elderly in the ED
Acute Pain
Primary: Clinical Improvement in NRS Pain Score — 62; 63 Participants
Phase 4 N=60 A Comparison of Proprietary Formulations of Oral Ketamine + Aspirin and Oral Ketamine Alone for Musculoskeletal Pain
Pain
Primary: Change in Pain Score at 60 Minutes — 2.18; 4.01 units on a scale
Phase 3 N=768 A Open-label Study to Evaluate the Safety of TRV130 in Patients With Acute Pain
Acute Pain
Primary: Number of Patients That Experienced a Treatment-emergent Adverse Event — 490 Participants
Phase 3 N=40 Choosing Opioid Management for Pain and Analyzing Acute Chest Syndrome (ACS) Rates Equally
Pain · Sickle Cell Disease
Primary: Acute Chest Syndrome — 2; 1 participants
Phase 3 N=350 Clinical Trial Comparing Two Protocols Using Intravenous (IV) Hydromorphone
Acute Pain
Primary: Number of Patients With Satisfactory Pain Management at 60 Minutes — 112; 113 Participants
Phase 3 N=150 DSUVIA Early Evaluation of Pain Trial
Traumatic Injury
Primary: Verbally Administered Numeric Rating Scale (VNRS) — 68; 66 units on a scale — p=0.56
Phase 4 N=180 IV Acetaminophen for Post-Operative Pain Management in Enhanced Recovery After Surgery (ERAS) Population
Abdominal Wall Hernia · Pancreatic Diseases · Bowel Disease
Primary: Postoperative Pain Intensity — 33; 42 Participants
N/A N=278 Ketamine for Acute Painful Crisis in Sickle Cell Disease Patients
Sickle Cell Crisis
Primary: Pain Scores — 5.6; 5.7 score on a scale
Phase 4 N=60 Ketamine For Acute Treatment of Pain in Emergency Department
Pain
Primary: Change From Baseline of Pain as Described by Numeric Rating Scale (NRS) [Minimum:0, Maximum 10] at 15 Minutes — 3.5; 6.0 units on a scale
Phase 2 N=298 Safety of Hydromorphone in Adult Patients Presenting to the Emergency Department With Acute Severe Pain
Acute Pain
Primary: Number of Participants Requiring Naloxone — 0 Participants
N/A N=156 Acute Pain Genomic Study
Osteoarthritis · Postoperative Pain
Primary: NRS-Pain With Movement on POD 2 — 2.83 units on a scale
Phase 3 N=350 Protocolized vs Discretionary Use of Opioids in Acute Pain
Pain
Primary: Percentage of Patients With Successful Treatment — 86.8; 76.6 Percentage of Participants
Phase 4 N=416 Comparative Efficacy of 4 Oral Analgesics
Pain
Primary: Between Group Difference in Change in Numerical Rating Scale (NRS) Pain Scores — 4.4; 3.5; 3.9; 4.3 units on a scale
Phase 4 N=172 Opioid Analgesia for MAB
MAB · Pain
Primary: Overall Maximum Self-reported Pain Score — 8; 8 units on a scale
Phase 4 N=66 IV Acetaminophen for Acute Post Operative Pain in C-Section Patients
Post-operative Pain
Primary: Opioid Requirements in Cesarean Section (C-section) Patient Population — 44; 48; 58; 57 mg
Phase 3 N=76 Open-Label Safety and Efficacy of the Sufentanil Sublingual Tablet 30 mcg for Acute Pain
Moderate-to-severe Acute Pain
Primary: Time-weighted Summed Pain Intensity Difference (SPID) Over the 1-hour (SPID1). — 2.11 units on a scale
N/A N=5,308 Matrifen® for Therapy of Severe Chronic Pain®
Severe Chronic Pain
Primary: Patient's Assessment of Pain Severity Score — 7.12; 3.32 Units on a scale
Phase 2 N=90 Pain Management in Children and Young Adults With Sickle Cell Disease
Sickle Cell Disease
Primary: Number of Participants With Successful Pain Interventions by Arm Between Presentation and 3 Hours Post Administration of Study Drug — 13; 17; 27; 25 Participants — p=0.227
Phase 4 N=32 Intravenous Lidocaine Versus Morphine for Severe Pain in the ED
Pain
Primary: Pain Score (NRS 0-10) — 5.1; 4.2 units on a scale
Phase 4 N=36 Continuous Lidocaine Infusion for Management of Perioperative Burn Pain
Thermal Burns
Primary: Narcotic Consumption (Measured in mg/kg Narcotic Consumption) — 57.5; 67.75 mg/kg narcotic consumption
Phase 4 N=65 Postoperative Pain Control in Septum and Sinus Surgery
Post-operative Pain · Sinus Surgery
Primary: Number of Doses of Opiate (Narcotic) Pain Medication — 1.0; 1.5 number of doses
Phase 4 N=64 Ultrasound Guided Pain Control Versus Standard Treatment in Emergency Department HIP Fracture Patients
Hip Fracture
Primary: Pain Score at 30 Minutes — 1.94; 2.05; 5.13 units on a scale — p=<.0001
N/A N=90 The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis
Perforated Appendicitis
Primary: Time Until PCA Discontinued After the Operation — 76.4; 86.7 hours
Phase 3 N=407 Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Abdominoplasty
Acute Pain
Primary: Number of Patients Who Respond to Study Medication at the 24-hr Numeric Pain Rating Scale (NPRS) Assessment Compared to Placebo. — 47; 61; 56; 37 Participants
N/A N=38 Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain
Chronic Pain · Chronic Lower Back Pain · Back Pain
Primary: Changes in Patient Reported Pain and Discomfort — 47; 13; -30; -18 percent change from baseline
N/A N=1,602 A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Acute Pain Trial)
Acute Pain
Primary: 10 Day Silverman Integrated Analgesic Assessment (SIA) Score — 1.4; -1.4 score on a scale — p=0.7957