N/A N=353 Testing a Digital Intervention for Adolescents
Rumination · Stress, Psychological
Primary: Change in Perceived Stress [Perceived Stress Scale (PSS)] — 26.33; 25.26; 22.01; 24.67 score on a scale — p=<.001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=33 Young Adult Eating Habits
Eating Behavior · Eating Habit
Primary: Change in Brain Response From Baseline to 2-weeks Post High UPF or 2 Weeks no UPF Diet — 0.02; 0.13 arbitrary units
N/A N=23 Insulin Resistance in Adolescents
Insulin Resistance
Primary: Linear Relationship Between HOMA-IR and Cognitive Function (R-squared) — 0.205; 0.299; 0.738; 0.0264 R-squared — p=0.162
N/A N=88 Adolescent Interventions to Manage Self-regulation of T1D (AIMS T1D)
Self-regulation · Medication Adherence
Primary: Change From Baseline in Youth Executive Function (Behavioral EF) at 8 Weeks (Z-score) — 0.02; -0.02 z-score
N/A N=66 Congenital Heart Adolescents: Program of Transition Evaluation Research
Congenital Heart Defects
Primary: Transition Readiness Assessment Questionnaire (TRAQ) Score — 2.77; 2.95; 3.80; 3.92 units on a scale
N/A N=123 Technology-Based Prevention for Adolescents in Primary Care
Substance Use
Primary: Enrollment and Recruitment Rate — 61; 62 Participants
N/A N=226 Reducing HIV Risk Among Adolescents: Evaluating HEART for Teens
HIV Infections · Sexually Transmitted Diseases
Primary: Acceptability — 88; 83 Participants
Phase 3 N=50 Pharmacokinetics, Safety, and Efficacy of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate Single Tablet Regimen (STR) in Adolescents
Acquired Immunodeficiency Syndrome · HIV Infections
Primary: For Part A, Pharmacokinetic (PK) Parameter: AUCtau of EVG — 31620.9 ng•h/mL
N/A N=146 Prevention of Adolescent Risky Behaviors: Neural Markers of Intervention Effects
Risk-Taking · Adolescent Behavior
Primary: Changes in Emotional Regulation — 54.43; 52.02; 54.47; 60.77 T Score — p=0.003
N/A N=223 Self-guided Treatment for Adolescents Navigating Depression
Depressive Symptoms · Depression · Depressive Disorder
Primary: Depressive Symptom Severity at Post-intervention — 8.39; 11.03 units on a scale — p=<0.001
N/A N=43 PureWick™ Adolescent Study
Healthy Volunteers, Adolescent
Primary: Performance of the PureWick System in Adolescents After HCP Placement and Self-placement — 90.40; 93.09; 87.15; 90.41 Percentage of urine captured
N/A N=250 Survey to Identify Substance Use in Teenagers and Adolescents
Anesthesia
Primary: Number of Participants With Adolescent and Parent Reported Alcohol, Drug, Vaping and Tobacco Usage — 1; 1; 0; 425 Participants
N/A N=294 Alcohol Screening in an Ethnically Diverse Sample of Adolescents in Primary Care
Alcohol Use · Drug Use
Primary: Number of Times Used Alcohol — 5.64; 5.18 score on a scale
Phase 4 N=203 Study in Adolescents With Schizophrenia or Bipolar Disorder
Bipolar I Disorder · Schizophrenia
Primary: Mean Change From Baseline to 52 Weeks in Body Mass Index (BMI) for All Participants — 3.64; 2.83 kilograms per meter squared (kg/m^2) — p=0.150
N/A N=168 A Study Examining Adolescents With Non-Suicidal Self-Injury
Self-Injurious Behavior · Deliberate Self-Harm
Primary: Self-Injurious Thoughts and Behaviors Interview (SITBI) - Lifetime Episodes — 73.29; 0 episode count
N/A N=36 Improving Adherence in Adolescents and Young Adults With Bipolar Disorder
Bipolar Disorder
Primary: Change From Baseline in the Tablet Routine Questionaire (TRQ) "Past Month" Item at 24 Weeks — 21.5; 28.0 percent of medications not taken
Phase 2 N=66 Biobehavioral Effects of Topiramate on Cannabis-Related Outcomes in Adolescents
Cannabis Abuse · Cannabis Dependence
Primary: Cannabis Use — 55.89; 63.10 Percentage of use days
Phase 2 N=90 An Adaptive Algorithm-Based Approach to Treatment for Adolescent Depression
Depressive Disorder
Primary: Children's Depression Rating Scale - Revised — 36.0; 37.5 score on a scale — p=0.76
N/A N=460 Alcohol, Marijuana, and Risky Sex: Group Interventions With Detained Adolescents
Risk Reduction Behavior · Health Behavior · Sexual Behavior
Primary: Number of Participants With Risky Sexual Behavior Measured for 1 Year — 143; 155; 162 Participants
N/A N=46 Activity, Adiposity, and Appetite in Adolescents 2
Obesity · Metabolic Disease · Insulin Sensitivity
Primary: Appetite- Subjective — 9239.4; 7879.6; 6130.5; 8970.0 score on a scale*min
Phase 2 N=49 Impact of Nicotine Reduction on Adolescent Cigarette Use, Alternative Tobacco Use, and Harm From Tobacco
Nicotine Dependence, Cigarettes, Uncomplicated
Primary: Average Cigarettes Smoked Per Day — 4.3; 8.0 average cigarettes per day — p=.111
N/A N=32 Activating and Connecting Teens (ACT) Study
Depression
Primary: Depression — 9.63 score on a scale
N/A N=116 Use of Continuous Glucose Sensors by Adolescents With Inadequate Diabetic Control
Type 1 Diabetes Mellitus
Primary: Glycated Hemoglobin (HbA1c) — 8.84; 9.03; 9.24; 9.14 percentage of hemoglobin molecules — p=0.86
N/A N=1,095 Adolescent Wellness Visits in Tanzania
HIV Testing · Contraceptive Usage
Primary: Number of Adolescents Who Self-reported HIV Testing and Counseling, Inclusive of the Adolescent Wellness Visit — 234; 86 Participants
N/A N=515 Prospective Cohort Study of Adolescents Living With HIV and Their Caregivers Attending a Psychosocial Programme in Botswana
Hiv
Primary: Quality of Life/Well-being (Young People) — 4.77 score on a scale
N/A N=48 Group Depression Treatment for Autistic Youth
Autism Spectrum Disorder · Depression · Suicidal Ideation
Primary: Change in Severity of Adolescent Depressive Symptoms, Self-report — 8.14 T-score
Phase 3 N=157 Varenicline for Adolescent Smoking Cessation
Nicotine Dependence
Primary: Number of Participants With Cotinine-confirmed 7-day Point Prevalence Abstinence at the End of Treatment — 4; 4 Participants
N/A N=18 Noise Reduction Preferences in Teenagers and Pre-teens
Hearing Loss
Primary: Subjective Rating of Listening Effort Questionnaire — 44.73; 44.5; 41.53; 35.86 units on a scale — p=0.007
N/A N=20 Feasibility and Effectiveness of Real-time, Remote Continuous Glucose Monitoring in Adolescents With Poorly Controlled Type 1 Diabetes
Diabetes Mellitus, Type 1 · Noncompliance, Patient
Primary: Change in Hemoglobin A1c From Baseline to 3 Months — -0.9 percent — p=0.03
Phase 4 N=312 Smoking Cessation Study In Healthy Adolescent Smokers
Smoking Cessation
Primary: 4-Week Continuous Abstinence Rate: Percentage of Participants Who Remained Abstinent From Week 9 Through Week 12 — 20.2; 27.2; 18.0 percentage of participants — p=0.6337