N/A N=85 Treatment for Affect Dimensions
Depression · Anxiety
Primary: Positive Affect Subscale of the Positive and Negative Affect Scale (PANAS-P) — 20.76; 29.42; 24.18; 19.42 score on a scale — p=.002
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=77 Using Affective Differences to Predict Response to Behavioral Treatment for Major Depressive Disorder
Depression
Primary: Analyses of Covariance to Test for Group Differences (MDD vs. Healthy) on Clinician-rated Depression Severity After 16 Weeks of Behavioral Activation Psychotherapy…
N/A N=15 Adolescent Attention to Emotion Study
Depression
Primary: Affect-biased Attention Following Neurofeedback (Immediately Post-Intervention) — .41 Proportion (0-1) — p=.004
Phase 1 N=61 Cognitive Behavioral Therapy for the Treatment of Seasonal Affective Disorder (SAD)
Seasonal Affective Disorder · Depression
Primary: Scores on the Structured Interview Guide for the Hamilton Depression Rating Scale-Seasonal Affective Disorder Version — 13.6; 13.3; 8.3; 22.6 units on a scale
Phase 2 N=775 Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders
Tobacco Use Disorder
Primary: Cigarettes Per Day (CPD) — 25.28; 19.95; 17.74 cigarettes per day — p=<0.0001
Phase 2 N=326 Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders
Tobacco Use Disorder
Primary: Cigarettes Per Day — 22.54; 14.32; 11.76; 7.63 cigarettes per day
N/A N=205 Depression Attention for Women Now (The DAWN Study)
Depressive Disorder
Primary: Depression Treatment Outcome — 0.96; 1.33 units on a scale
Phase 4 N=40 Depression, Epinephrine, and Platelet Function
Major Depressive Disorder
Primary: Response of Participants, Defined by Change in the 21-item Hamilton Depression Rating Scale (HDRS) From Baseline to Week8 — 5; 9; 2; 4 participants — p=.918
N/A N=52 Skills to Enhance Positive Affect in Suicidal Adolescents
Suicidal Ideation · Suicide, Attempted
Primary: Dot Probe Task — 1.56; -1.65; -1.48; 1.23 milliseconds — p=.034
N/A N=60 Acute Alcohol Response In Bipolar Disorder: a fMRI Study
Bipolar Disorder · Alcohol Drinking · Alcohol Use Disorder
Primary: Level of Intoxication (Subjective Response) on Each Condition Day After Drinking Relative to How They Felt When Arriving to the Lab on That Respective Day )Prior to…
Phase 4 N=79 Evaluation of Emotional Disorders During Treatment by Interferon Beta in Relapsing-remitting Multiple Sclerosis Patients
Multiple Sclerosis, Relapsing, Remitting
Primary: Change From Baseline in Emotional Dyscontrol Sub-score of the Depressive Mood Scale (Echelle d'Humeur Depressive [EHD]) Scale at Month 12 — 12.7; -0.5 units on a scale
N/A N=94 Stress and the Sympathetic Nervous System in Adults With Depression
Major Depressive Disorder
Primary: Percent of Days Participants Report Stressors — 36; 40 percent of days
N/A N=28 Neurobehavioral Intervention as a Novel Treatment Approach for Emotion-Regulatory Deficits
Anxiety · Depression
Primary: Reaction Time to Facial Affect Identification During Emotional Conflict — 802.15; 889.14; 848.79; 937.97 milliseconds — p=0.004
Phase 2 N=97 Assessing Symptomatic Clinical Episodes in Depression
Major Depressive Disorder
Primary: MADRS Score - Overall Change From Baseline — 13.7; 8.8 score on a scale — p=<.001
N/A N=100 Supportive and Supportive-Expressive Treatment for Depression
Major Depressive Disorder
Primary: Hamilton Rating Scale for Depression (HRSD) — 12.32; 12.06; 20.20; 20.08 units on a scale — p=.016
N/A N=99 fMRI Studies of Emotional Brain Circuitry in People With Major Depression
Depression
Primary: Activations in Different Cortical Regions Caused by Emotionally Evocative Task — -0.021; 0.084; 0.021; -0.030 Voxels
N/A N=38 Attachment and Biobehavioral Catch-up and Depression Treatment
Maternal Depression · Child Behavior Problem
Primary: Change in Patient-Reported Outcomes Measurement Information System (PROMIS) Depression Score — 6.70; 6.98 units on a scale — p=.85
N/A N=1,206 Epidemiology of Depression, Anxiety, and Cognitive Impairment
Depression · Anxiety · Cognitive Impairment
Primary: Participants With Depression by Patient Health Questionnaire - 9 — 177 participants
N/A N=108 A Personalized Approach to Effects of Affective Bias Modification on Symptom Change and Rumination
Major Depressive Disorder
Primary: Self-reported Depressive Symptoms: Becks Depression Inventory-II — 19.1; 16.5; 5.3 score on a scale — p=.05
Early Phase 1 N=22 Effects of Drugs on Responses to Brain and Emotional Processes
Autism Spectrum Disorder · Healthy
Primary: Change in Responses to Affective Touch — 3.01; 4.06 units on a scale
N/A N=32 Activating and Connecting Teens (ACT) Study
Depression
Primary: Depression — 9.63 score on a scale
N/A N=36 Effect of Amygdala Neurofeedback on Depressive Symptoms and Processing Biases
Major Depressive Disorder
Primary: Change From Baseline in Montgomery Asberg Depression Rating Scale at 2 Weeks — 23.5; 23.8; 11.9; 21.9 units on a scale — p=<0.001
Phase 4 N=107 Cost- Effectiveness and Quality of Life Assessment in Mood Disorder
Bipolar Disorder
Primary: Number of Participants With Response to Treatment" — 31; 28; 27 Participants
N/A N=29 Positive Valence System Enhancement Treatment for Anxiety and Depression: Clinical Efficacy and Neural Changes
Anxiety Disorders and Symptoms · Depression
Primary: Change From Baseline in Positive Affect (Positive and Negative Affect Schedule; Modified Differential Emotions Scale; Composite) — -0.41; -0.40; 0.73; -0.02 z-score
N/A N=64 Virtual Reality Compared to Screen Based Engagement on Mood
Virtual Reality
Primary: Change in Positive Affect and Negative Affect From Baseline to After a 2 Minute Mood Induction — 3.7; 4.63; 1.97; 1.56 units on a scale
Phase 4 N=183 A Collaborative Care Program to Improve Treatment of Depression and Anxiety Disorders in Cardiac Patients
Depression · Generalized Anxiety Disorder · Panic Disorder
Primary: Change in Mental Health-related Quality of Life From Baseline to 24 Weeks — 8.87; 8.39 units on a scale — p=0.002
N/A N=1,385 Sleep to Prevent Evolving Affecting Disorders
Insomnia, Primary · Depression
Primary: Severity of Depression as Measured by the Quick Inventory of Depressive Symptomatology (QIDS) Pre-Treatment — 10.8; 10.8 score on a scale
N/A N=196 Community Study of Outcome Monitoring for Emotional Disorders in Teens
Depression · Anxiety
Primary: Clinical Global Impression - Improvement (CGI-I) Scores — 2.85; 3.20; 3.02; 2.47 score on a scale — p=.338
N/A N=270 Brain Mechanisms of Human Motivation
Major Depressive Disorder · Bipolar Disorder
Primary: Change in Response Bias — .0546; .0787 log-transformed ratio of scores
Phase 4 N=50 Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder
Seasonal Affective Disorder
Primary: Sleep Satisfaction at Baseline and Measured Monthly, as Measured by the Pittsburgh Sleep Quality Index (PSQI) — 11.56; 11.45; 9.52; 8.67 scores on a scale