Clinical Trial Search

Primary: Number of Participants Who Were Exposed to LX6171 — 35; 33; 31 Participants

Primary: FCI Score at Follow-up — 147.3; 164.0; 123.3; 150.8 points awarded for correct items

Primary: Face-name Memory Test Performance — -.28; -.01; -1.29; -1.76 pairs correctly recalled/recognized

Primary: Change in Total Recall Score in the Selective Reminding Test — 5.7; 9.4 score on a scale — p=0.05

Primary: Change From Baseline in Rey Auditory Verbal Learning Test — 1.53; 1.00; 5.30; 4.02 number of words correctly recalled

Primary: Number of Participants With a Decline of 6 Points on the Hopkins Verbal Learning Test-Revised (HVLT-R) — 1; 9 Participants — p=.02

Primary: System Usability Scale (SUS) — 90.6 score on a scale

Primary: Hopkins Verbal Learning Test-Revised (HVLT-R) — 23.52; 20.04; 23.68; 20.39 score on a scale

Primary: Change in Clinical Dementia Rating Scale - Sum of Boxes (CDR-SB) Score From Baseline — 1.1; .9 score on a scale

Primary: Retention and Recruitment Rates — 21 Participants

Primary: Auditory Memory Attention Index — 89.0; 94.3 standard score units — p=<0.01

Primary: MAAT-G Feasibility Completion Rate — 10 Participants

Primary: Brain Activity in the Dentate Gyrus / CA3 Subregion of the Hippocampus Measured With Blood Oxygenation Level Dependent (BOLD) Functional MRI — -0.1203; 0.4353; -0.2238…

Primary: Mean of the Functional Assessment of Cancer Therapy-Cognition (FACT-COG) — 155.8; 152.7 score on a scale

Primary: Everyday Memory Failures — 0.55; 0.62 average daily number memory failures/day — p=.67

Primary: fMRI Measure of Hippocampal Activation — 36.4; 41.3 percentage of active voxels

Primary: Percent of Correct Object Location Associations Assessed up to 1 Month Post-treatment — 80.0; 62.45 percent correct — p=<.001

Primary: Gait Speed Normal Walk (cm/s). — 112.23; 103.42; 121.58; 119.51 cm/s — p=0.025

Primary: Annualized Percent Change in Ventricular Volume (APCV) as Measured by MRI — 5.87; 8.14; 6.26; 7.08 percent change per participant year

Primary: Selective Reminding Test (SRT) — 33.61; 36.23; 36.81; 37.13 Words

Primary: Word List Memory Total - ADAS-cog — 14.35; 14.7; 15.1; 14.67 Words recalled

Primary: Change in the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) — -0.89; 0.55 score

Primary: California Verbal Learning Test II — 6.9; 6.2; 6.46; 5.10 units on a scale — p=0.048

Primary: Change in Readiness to Engage in ACP (ACP Engagement Scale) — 1.92; 1.54; 2.77; 2.00 units on a scale

Primary: Acute Effect of a rTMS Session on the Performance for a Working Memory Task, as Measured by Accuracy (in Percentage) — 50.43; 55.42; 83.93; 46.49 percentage of accuracy

Primary: Number of Participants With Treatment-Emergent Adverse Event (TEAEs) — 34; 26 Participants

Primary: Change in Global Cognition Assessed by RBANS — 434.66; 435.36; 438.46; 436 Score on a Scale — p=0.9644

Primary: ADAS-Cog-Exec Global Composite — -0.146; -0.068 Change score — p=0.29

Primary: Selective Reminding Test (SRT) Total Recall — 45.6; 46.6 Words

Primary: Amyloid Deposition Obtained on a 18F-flutemetamol Brain Scan. — 1.65 ratio of flutemetamol absorbed — p=<0.05