Phase 2 N=35 IMPACT: Safety and Feasibility of a Single-stage Procedure for Focal Cartilage Lesions of the Knee.
Foreign-Body Reaction · Inflammation · Effusion (L) Knee
Primary: Safety: Adverse Events — 0 participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=118 RCT of ChondroCelect® (in an ACI Procedure) vs Microfracture in the Repair of Cartilage Defects of the Knee
Articular Cartilage Lesion of the Femoral Condyle
Primary: Histomorphometry Safranin-O + Anti-Collagen II Antibody Staining — 1.01; 0.75 Ratio — p=0.003
Phase 3 N=30 Effects of CHONDRON (Autologous Chondrocytes) With Ankle Cartilage Defect
Articular Cartilage Defects of Ankle Joint
Primary: Average Change From Baseline in American Orthopedic Foot and Ankle Society(AOFAS) at 12 Months Post-surgery — 16.93 scores
Phase 3 N=144 Superiority of MACI® Versus Microfracture Treatment in Patients With Symptomatic Articular Cartilage Defects in the Knee
Articular Cartilage Defect
Primary: Change From Baseline to Week 104 for the Participant's Knee Injury and Osteoarthritis Outcome Score (KOOS) Pain and Function (Sports and Recreational Activities) Scores…
N/A N=19 Comparison of BioCartilage Versus Marrow Stimulating Procedure for Cartilage Defects of the Knee
Defect of Articular Cartilage
Primary: MRI Repair Tissue Comparison — 10; 2; 3; 4 Participants — p=0.61
Phase 3 N=9 Evaluation of the CR Plug for Repair of Defects Created at the Harvest Site From an Autograft in the Knee.
Knee Injury
Primary: MRI to Evaluate Success of Outcome. — 88.6 units on a scale
Phase 2 N=12 Evaluation of Safety and Exploratory Efficacy of CARTISTEM®, a Cell Therapy Product for Articular Cartilage Defects
Degeneration Articular Cartilage Knee
Primary: IKDC Score — 32.0; 25.5 score on a scale
N/A N=80 Trial Comparing BST-CarGel and Microfracture in Repair of Articular Cartilage Lesions in the Knee
Knee Injuries
Primary: Degree of Filling of the Lesion by Repair Tissue at 12 Months Through MRI. — 92.81; 85.22 Percentage of lesion fill — p=0.011
N/A N=24 Effects of Unloader Bracing in Clinical Outcome and Cartilage Physiology Following Microfracture of Chondral Defects
Cartilage Loss · Microfracture
Primary: Knee Injury and Osteoarthritis Outcome Score (KOOS) (Clinical Outcome) — 12.0; 4.1; 19.1; 8.1 units on a scale — p=0.162
N/A N=146 Arthroscopy in the Treatment of Degenerative Medial Meniscus Tear
Osteoarthritis, Knee
Primary: The Lysholm Knee Score — 82.2; 83.4 units on a scale
Phase 2 N=102 Study of TG-C in Patients With Grade 3 Degenerative Joint Disease of the Knee
Osteoarthritis, Knee
Primary: Change From Baseline in the International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Score at 1 Year — 23.3; 9.9 scores on a scale — p=<0.01
Phase 2 N=20 Autologous, Micro-fragmented Adipose Tissue for Meniscal Tears
Tibial Meniscus Injuries · Osteoarthritis, Knee
Primary: Change in Numerical Pain Scale — -3.2 units on a scale
N/A N=10 A Biologic Joint Replacement Strategy to Treat Patients With Severe Knee Trauma and Post-Traumatic Knee Osteoarthritis
Post-traumatic Osteoarthritis
Primary: Visual Analogue Scale Pain Score — 2.3 units on a scale
N/A N=128 Extension Study for Participants of MACI00206 Study of MACI® for the Treatment of Symptomatic Articular Cartilage Defects of the Knee
Articular Cartilage Defects
Primary: Change From MACI00206 Baseline for the Participant's Knee Injury and Osteoarthritis Outcome (KOOS) Pain and Function (Sports and Recreational Activities) Scores…
N/A N=67 Follow-Up Study Evaluating The Long Term Safety and Efficacy of BST-CarGel and Microfracture Repair of the Knee
Knee Injuries
Primary: Degree of Lesion Filling (%Fill) by Repair Tissue at Degree of Lesion Filling (%Fill) by Repair Tissue at 5 Years Through MRI. — 93.79; 86.96 Percentage of lesion filled…
N/A N=150 The Effect of Bone-void Filler on Anterior Knee Pain Following ACL Reconstruction
ACL
Primary: Score on Knee Injury and Osteoarthritis Outcome Score (KOOS) Survey — 67; 69; 67.7 score on a scale
N/A N=131 Subchondroplasty® Knee RCT
Bone Marrow Edema · Knee Pain Chronic · Knee Osteoarthritis
Primary: Composite Clinical Success — 68; 38; 16; 4 Participants — p=>0.01
N/A N=101 Role of Bone in Knee Osteoarthritis (OA)
Osteoarthritis, Knee
Primary: Number of Participants With Viable Specimens for Genetic Analysis — 14 participants
N/A N=251 Agili-C™ Implant Performance Evaluation
Cartilage or Osteochondral Defects in the Knee · Up to Moderate Osteoarthritis
Primary: Overall Knee Injury and Osteoarthritis Outcome Score (KOOS) Change From Baseline to 60 Months — 38.75; 19.52 score on a scale
Phase 3 N=24 Allograft Transplantation in the Treatment of Osteoarthritis of the Metatarsophalangeal (MTP) Joint of the Great Toe
Osteoarthritis
Primary: Allograft Stability — 0
N/A N=351 Comparing Surgery Versus Standard Physical Therapy in Treating People With a Meniscal Tear and Osteoarthritis
Osteoarthritis
Primary: WOMAC Functional Status - Difference From Baseline — 20.9; 18.5 Score — p=0.26
N/A N=18 High-Purity Type I Collagen Augmentation in Meniscal Repair
Meniscus Tear · Knee Meniscus Injury · Meniscal Repair
Primary: Safety of High-Purity Type I Collagen Augmentation — 0; 0; 0; 0 Participants
N/A N=15 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee
Osteochondritis Dissecans
Primary: Greater Cartilage Healing Measured by Glycosaminoglycan Content on dGEMRIC MRI
Phase 2 N=82 Safety and Efficacy of RHH646 for Knee Osteoarthritis
Osteoarthritis, Knee
Primary: Change From Baseline in Cartilage Volume in the Index Region of the Target Knee by MRI — 94.6; 9.3 µL — p=0.0575
N/A N=140 Surgical or Exercise Therapy on Patients With Degenerative Meniscus Tears
Degenerative Meniscal Tear
Primary: KOOS4 - Change From Baseline — 24.4; 25.3 units on a scale — p=<0.05
Phase 3 N=40 The Effect of Micro Fragmented Adipose Tissue (MFAT) on Knee Osteoarthritis
Osteoarthritis, Knee · Knee Pain
Primary: Change in Knee Injury and Osteoarthritis Outcomes Score (KOOS) Score - Pain — 64.4; 62.5; 63.9; 13.2 score on a scale — p=0.594
N/A N=30 Management of Traumatic Bone Defects in Tibial Plateau Fractures With Antibiotic-Impregnated Biodegradable Calcium Sulfate Beads: A Prospective Clinical Trial
Tibial Fractures · Intra-Articular Fractures · Fracture Fixation, Internal
Primary: Resorption of Study Device — 4 Participants
N/A N=50 Comparison of SVF Injection With and Without Microfracture in Moderate Knee Osteoarthritis
Knee Osteoarthritis (Knee OA)
Primary: Change in WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) — 49.52; 50.60; 34.16; 49.96 Score
N/A N=34 Optimizing Movement After Anterior Cruciate Ligament Injury
Anterior Cruciate Ligament Injuries · Knee Osteoarthritis
Primary: Knee Flexion Moment Impulse — 0.54; 0.50 Ratio — p=0.293
N/A N=23 In Vivo Three-Dimensional Determination of Osteoarthritis Brace Effectiveness
Osteoarthritis, Knee
Primary: Medial Condylar Separation With Brace — 0.60 mm