Phase 2 N=35 IMPACT: Safety and Feasibility of a Single-stage Procedure for Focal Cartilage Lesions of the Knee.
Foreign-Body Reaction · Inflammation · Effusion (L) Knee
Primary: Safety: Adverse Events — 0 participants
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Early Phase 1 N=48 Serum Cartilage Oligomeric Matrix Protein Levels After 12 Weeks of Different Exercises
Osteoarthritis · Articular Cartilage Disorder of Knee · Degenerative Lesion of Articular Cartilage of Knee
Primary: Changes in Serum COMP Accumulation, Triggered by Acute Exercise, After 12 Weeks of Different Regular Exercises — -1.60; -0.53; -0.19; -0.12 U/l
Phase 4 N=12 To Look at the Characteristics of Synovial Fluid and Cartilage Matrix in Osteoarthritic Knee After Hyaluronic Acid Injection
Knee Osteoarthritis
Primary: To Identify Imaging Markers for Characterizing the Biochemical Profiles in Synovial Fluid and Cartilage in Knee OA After HA Injection
N/A N=80 Trial Comparing BST-CarGel and Microfracture in Repair of Articular Cartilage Lesions in the Knee
Knee Injuries
Primary: Degree of Filling of the Lesion by Repair Tissue at 12 Months Through MRI. — 92.81; 85.22 Percentage of lesion fill — p=0.011
N/A N=34 Optimizing Movement After Anterior Cruciate Ligament Injury
Anterior Cruciate Ligament Injuries · Knee Osteoarthritis
Primary: Knee Flexion Moment Impulse — 0.54; 0.50 Ratio — p=0.293
N/A N=16 Comparative Efficacy of the Masquelet Versus Titanium Mesh Cage Techniques for the Treatment of Large Long Bone Defects
Segmental Long Bone Defects
Primary: Number of Participants With Defect Healing - Plain Radiography — 9; 7 Participants
Phase 2 N=141 Study of Safety, Tolerability, Preliminary Efficacy of Intra-articular LNA043 Injections in Patients With Articular Cartilage Lesions and Knee Osteoarthritis.
Osteoarthritis
Primary: Change From Baseline in Articular Cartilage Collagen Organization in the Overall Cartilage (Femoral and Patellar Lesions) - Part A — 3.02; 2.86; 5.59; 2.05 ms
Phase 3 N=380 Effect of Diacerein vs Celecoxib on Symptoms and Structural Changes in Symptomatic Knee Osteoarthritis
Osteoarthritis · Osteoarthritis, Knee
Primary: Change Form Baseline in WOMAC A Pain Subscale — -11.14; -11.82 cm — p=<0.025
N/A N=148 Pending Failure in Hard-hard Total Hip Arthroplasty
Infection and Inflammatory Reaction
Primary: Number of Participants With Chromium and Cobalt Ion Levels Above 7ug/l — 14; 0 participants above limit
N/A N=86 Randomized Evaluation of the Efficacy of Synvisc-One® for the Treatment of Patellofemoral Chondromalacia
Chondromalacia Patella · Patellofemoral Pain Syndrome
Primary: Knee Pain During a Single Leg Squat — 5.6; 5.2; 4.1; 3.4 units on a scale
Phase 3 N=30 Effects of CHONDRON (Autologous Chondrocytes) With Ankle Cartilage Defect
Articular Cartilage Defects of Ankle Joint
Primary: Average Change From Baseline in American Orthopedic Foot and Ankle Society(AOFAS) at 12 Months Post-surgery — 16.93 scores
N/A N=115 Changes in Knee Articular Cartilage Volume in Women on Aromatase Inhibitors
Arthralgia
Primary: Knee Cartilage Volume — 2042; 1971 mm³
N/A N=22 Iterative Design of Custom Dynamic Orthoses to Reduce Articular Contact Stress
Ankle Fractures · Post-traumatic Osteoarthritis · Osteoarthritis Ankle
Primary: Joint Contact Stress Time Exposure (Model Estimated) — 4.44; 3.97; 4.08; 4.25 MPa-s/gait cycle
N/A N=75 Comparison of Acetaminophen and PRP Therapy for Knee OA
Knee Osteoarthritis
Primary: Change in Western Ontario and McMaster Universities Arthritis Index (WOMAC) — 3.0; 2.9; 8.0; 7.4 units on a scale
Phase 3 N=144 Superiority of MACI® Versus Microfracture Treatment in Patients With Symptomatic Articular Cartilage Defects in the Knee
Articular Cartilage Defect
Primary: Change From Baseline to Week 104 for the Participant's Knee Injury and Osteoarthritis Outcome Score (KOOS) Pain and Function (Sports and Recreational Activities) Scores…