N/A N=62 Training in Ataxia - Individuals With Degenerative Cerebellar Diseases
Cerebellar Ataxia
Primary: Change in Assessment and Rating of Ataxia (SARA) Score — -2.4; -0.9; -1.5; -0.2 score on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=21 Rehabilitative Trial With Cerebello-Spinal tDCS in Neurodegenerative Ataxia
Ataxia, Cerebellar · Cerebellar Ataxia · Spinocerebellar Ataxias
Primary: Change in the International Cooperative Ataxia Rating Scale (ICARS) Score From Baseline — 53.0; 52.7; 43.0; 52.1 units on a scale — p=<0.001
N/A N=21 Could Tai-chi Help Maintain Balance of Spinocerebellar Ataxia Patients
Spinocerebellar Ataxias · Tai Chi
Primary: Scale for the Assessment and Rating of Ataxia(SARA) — 11.5; 9 score on a scale
N/A N=4 Effects of High Intensity Stepping Training on Gait in Patients With Ataxia
Cerebellar Ataxia
Primary: Walking Speed in Meters Per Second as Assessed by the 10 Meter Walk Test(10MWT) — 0.13; 0.60 meters per second
N/A N=20 Transcranial Magnetic Stimulation in Spino-Cerebellar Ataxia
Spinocerebellar Ataxia
Primary: Percent Change From Baseline to Post Treatment on the Scale for the Assessment and Rating of Ataxia (SARA) — -25.9; -27.8 percentage change — p=0.29
N/A N=11 The Role of Cerebellar Hyperactivity in Parkinson's Disease
Parkinson's Disease
Primary: Change in Gait Speed- Sham_On — -0.0185 meters per second (m/s)
N/A N=21 Using Real-time fMRI Neurofeedback and Motor Imagery to Enhance Motor Timing and Precision in Cerebellar Ataxia
Cerebellar Ataxia · Spinocerebellar Ataxias · Cerebellar Degeneration
Primary: Change in Overt Tapping Accuracy as Assessed by Finger Tapping to a Flashing Cue at 1Hz Speed — .00141488 taps per second
Phase 2 N=22 Intra-Erythrocyte Dexamethasone Sodium Phosphate in Ataxia Teleangiectasia Patients
Nervous System Disorder · Genetic Syndrome
Primary: Mean Change From Baseline in Neurological Symptoms Assessed by Using International Cooperative Ataxia Rating Scale (ICARS) Score - ITT Population — -2.2; -3.4; -4.0…
N/A N=20 Dalfampridine and Gait in Spinocerebellar Ataxias
Spinocerebellar Ataxias Type 1 · Spinocerebellar Ataxias Type 2 · Spinocerebellar Ataxias Type 3
Primary: Change in Timed 25 Feet Walking Test (T25FW) — 23.7; 24.4; -1.1; -0.3 second — p=>0.05
Phase 3 N=176 Intra-Erythrocyte Dexamethasone Sodium Phosphate in Ataxia Telangiectasia Patients
Nervous System Disease · Genetic Syndrome
Primary: Change From Baseline in Modified International Cooperative Ataxia Rating Scale (mICARS) — 0.8; 1.0; 2.3 score on a scale — p=0.0847
Phase 3 N=141 Trial in Adult Participants With Spinocerebellar Ataxia (SCA)
Spinocerebellar Ataxias · Spinocerebellar Ataxia Genotype Type 1 · Spinocerebellar Ataxia Genotype Type 2
Primary: Change From Baseline in Total Score on the Scale for the Assessment and Rating of Ataxia (SARA) at Randomization Phase Week 8 — -0.810; -1.059 score on a scale — p=0.519
Phase 3 N=105 Evaluate the Neurological Effects of EryDex on Subjects With A-T
Ataxia Telangiectasia
Primary: Rescored Modified International Cooperative Ataxia Rating Scale (RmICARS) — 0.94; 2.24 RmICARS score (0-29 points)
Phase 2 N=67 Efficacy, Tolerability, and Pharmacokinetics of Multiple Doses of Oral TAK-831 in Adults With Friedreich Ataxia
Friedreich Ataxia
Primary: Change From Baseline in the Inverse Time to Complete the 9-Hole Peg Test (9-HPT-1) — 0.00038; -0.00017; -0.00032 1/seconds — p=>0.999
Phase 2 N=10 Citocoline for Treatment in Fragile X-associated Tremor/Ataxia Syndrome
Fragile X Tremor/Ataxia Syndrome
Primary: FXTAS Rating Scale Score — 45.8 score on a scale
N/A N=7 Cerebellar Transcranial Direct Current Stimulation in Parkinson's Disease
Parkinson Disease · Brain Stimulation · Cerebellum
Primary: Speed Walked During 30 Meter Walk Test — 5.63; 5.65; 5.77; 5.86 meters per second (m/s)
N/A N=8 Postural Stability in Cervical Spinal Myelopathy
Cervical Spondylotic Myelopathy
Primary: Virtual Environment TBI System (VETS) Assessment of Static Posturography — 11; 13.0; 48.4; 19.1 Square Centimeters
N/A N=28 Cerebellar Transcranial Direct Current Stimulation and Aphasia Treatment
Stroke
Primary: Change in Accuracy of Naming Untrained Pictures (Philadelphia Naming Test:PNT) Pre-treatment to Post-treatment — 5.76; 1.88 score on a scale — p=0.24
N/A N=26 Targeting Cerebellum to Treat Psychosis: a Transcranial Magnetic Stimulation (TMS) Study
Schizophrenia · Schizoaffective Disorder · Bipolar Disorder I
Primary: Change (Δ) in Accuracy of Time Interval Discrimination Pre- and Post-TMS — .503; .521; .456; .479 accuracy (proportion correct) — p=0.51
N/A N=8 Cerebellar rTMS for the Treatment of Schizophrenic Patients
Schizophrenia
Primary: Adverse Events — 1 event
Phase 4 N=1 An Objective Double-blind Evaluation of Bupropion and Citalopram in an Individual With Friedreich Ataxia
Friedreich Ataxia
Primary: International Cooperative Ataxia Rating Scale (ICARS) — 39; 30; 47; 46 units
N/A N=55 Quantifying Patient-Specific Changes in Neuromuscular Control in Cerebral Palsy
Cerebral Palsy
Primary: Change in Walk Dynamic Motor Control Index 6-months After Orthopaedic Surgery — -2.4 normalized z-score
Phase 3 N=63 A Study of TEV-50717 (Deutetrabenazine) for the Treatment of Dyskinesia in Cerebral Palsy in Children and Adolescents
Cerebral Palsy, Dyskinetic
Primary: Change From Baseline in the Movement Disorder-Childhood Rating Scale (MD-CRS) Part II Total Score (Movement Disorder Severity, Centrally Read) at Week 15 — -0.4; -1.5…
Phase 2 N=80 Atorvastatin Treatment of Cavernous Angiomas With Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial
Cerebral Cavernous Malformation
Primary: Percent Change in Mean Lesional QSM (QSM Change Score) — 7.35; 0.24; 15.18; 26.80 absolute value of percent change
Phase 2 N=22 Efficacy of EGb761 in Patients Suffering From Friedreich Ataxia
Friedreich Ataxia
Primary: Creatine Rephosphorylation Rate Post Exercise — 0.024; 0.029; 0.022; 0.029 pH per second — p=0.9133
Phase 2 N=10 (+) Epicatechin to Treat Friedreich's Ataxia
Friedreich's Ataxia
Primary: Change From Baseline in Friedreich Ataxia Rating Scale (FARS) Composite Score — 55.0 score on a scale — p=0.336
N/A N=32 Therapeutic Effects of Constraint-Induced Movement Therapy on Young Children With Cerebral Palsy
Cerebral Palsy Spastic Hemiplegic
Primary: Change From Baseline Pediatric Motor Activity Log (PMAL) Score at Post Test — 0.83; 0.00; 0.50; -0.05 score on a scale
N/A N=94 Memantine Treatment in Fragile X-Associated Tremor/Ataxia Syndrome
Fragile X-Associated Tremor/Ataxia Syndrome · Fragile X Premutation Carriers
Primary: Change From Baseline in Executive Functioning as Measured by the Behavioral Dyscontrol Scale II (BDS-II) — 17.44; 16.12; 15.66; 15.72 units on a scale
N/A N=18 Cerebellar tDCS and Balance Training in PwMS
Multiple Sclerosis
Primary: Score on the Berg Balance Scale — 54.43; 51.43; 54.67; 50.33 units on a scale
N/A N=46 Neurologic Injuries in Adults With Urea Cycle Disorders
Brain Diseases, Metabolic, Inborn · Urea Cycle Disorder · Ornithine Transcarbamylase Deficiency
Primary: Concentration of Glutamine and Myoinositol by MRS — 4.97; 3.66; 3.78; 4.50 mM — p=0.003
N/A N=9 Therapeutic Dance Intervention for Children With Cerebral Palsy
Cerebral Palsy
Primary: Congruent Trial (Hearts) Accuracy — 87.96; 87.50 percentage of correct