Phase 4 N=14 Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI
Osteonecrosis
Primary: Signal to Noise Ratio (SNR) — 33.82; 129.56 dB — p=0.002
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=110 Efficacy of Zoledronic Acid in Preventing Collapse of the Osteonecrotic Femoral Head
Avascular Necrosis of Femoral Head
Primary: Number of Participants With Femoral Head Collapse Within 24 Months — 29; 22 participants
N/A N=62 DePuy Trochanteric (ATN) Nailing Clinical Outcomes Trial
Femoral Fracture (Proximal)
Primary: Success in Terms of the Merle D'Aubigne Postel Score for Pain Category — 4.1; 4.4; 4.5; 4.6 Units on a scale
N/A N=9 Assessment Of Vascular Health After Niacin Therapy (AVANT)
Coronary Artery Disease · Carotid Artery Disease · Peripheral Artery Disease
Primary: Change From Baseline in Arterial Fluorodeoxyglucose (FDG) Uptake Assessed by FDG-PET/CT — -0.02; -0.05 Target to Background Ratio (TBR)
Phase 2 N=51 Hypertension Intervention to Reduce Osteonecrosis in Children With Acute Lymphoblastic Leukemia/Lymphoma
Hypertension · Osteonecrosis · Osteonecrosis Due to Drug
Primary: Extensive Radiographic Osteonecrosis — 20; 21; 1; 2 Participants — p=0.7139
Phase 4 N=24 Management of Mandibular ORN: PENTO as Medical Treatment
Osteoradionecrosis
Primary: Bone and/or Tissue Healing as Measured With the Classification of ORN Stages, Area of Bone Exposed (mm2) and Radiological Findings (OPG). — 14; 15; 13; 15 mm2
N/A N=23 Skeletal Muscle Atrophy and Dysfunction Following Total Knee Arthroplasty
Knee Osteoarthristis
Primary: Cross-sectional Area (CSA) of Muscle Fibers — 2680; 2377; 2028; 1882 micron squared
N/A N=38 Geniculate Artery Embolization for Treatment of Osteoarthritis
Osteoarthritis
Primary: Percentage Change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) - Pain Score — -50.1 Percentage change
Phase 2 N=112 Effect of Bevacizumab on Radiation-induced Brain Necrosis in Patients With Nasopharyngeal Carcinoma
Nasopharyngeal Carcinoma · Adverse Effect of Radiation Therapy · Brain Necrosis
Primary: Number of Participants With a Treatment Response — 38; 17 Participants
N/A N=15 ViviGen Cellular Bone Matrix for Hindfoot or Ankle Arthrodesis
Ankle Deformity · Ankle Arthritis
Primary: Union Rates — 23 joints fused
N/A N=262 Acinetobacter Baumannii-related Osteomyelitis: Clinical and Epidemiological Characterization
Osteomyelitis
Primary: Description of the Clinical and Epidemiological Profile of Patients With Infection — 92; 26; 25; 21 Participants
Phase 4 N=442 Prospective, Multicentre, Open-label Study Evaluating 1.5 mg/Day of Fondaparinux.
Major Orthopaedic Surgery and Renal Impairment
Primary: Number of Patients With Major Bleedings Between Day 1 and Day 10. — 20 participants
N/A N=45 Using Ultrasound Elastography to Predict Development of SOS
Sinusoidal Obstruction Syndrome · Complications of Bone Marrow Transplant
Primary: Sensitivity and Specificity of US for VOD/SOS — 80; 93 percentage of participants
N/A N=118 ViBone in Cervical and Lumbar Spine Fusion
Spondylosis · Cervical Spondylosis · Spondylolisthesis
Primary: Fusion Rates Per Level Using the Bridwell Interbody Grading Scale — 64; 50 Fusions
Phase 3 N=7 Investigating the Use of Prolia (Denosumab) in the Treatment of Acute Charcot Neuroarthropathy
Charcot Joint of Foot
Primary: Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability] — 0; 7 Participants
N/A N=68 Ceramic-on-ceramic THA for Post-traumatic Hip Osteoarthritis After Acetabular Fracture
Hip Osteoarthritis · Post-traumatic Osteoarthritis
Primary: Survival Rates of the Hip Implants — 96.3 percentage of non-revised implants
N/A N=25 Tissue Removal Assessment With Ultrasound of THe SFA and Popliteal
Peripheral Artery Disease · PAD · Claudication
Primary: Rate of Clinically Driven Target Lesion Revascularization (TLR) — 4.0; 8.2 % probablity of clinically driven TLR
N/A N=117 Heterotopic Ossification Prophylaxis
Acetabular Fracture · Heterotopic Ossification
Primary: Number of Participants With Severe HO Formation — 3; 9 Participants
N/A N=125 Non-invasive Computer-Aided Phenotyping of Vasculopathy
Carotid Atherosclerosis · Peripheral Arterial Disease
Primary: Measurement Bias of Calcification Analyzed by vascuCAP™ Non-invasively Relative to Histopathology as Ground Truth. — -0.47; .07 mm2
Phase 2 N=117 OZONE_EXO: Comparative Analysis of Protocols for Dental Exactions in Patients at Risk of MRONJ: Case-control Study
MEDICATION RELATED OSTEONECROSIS OF THE JAW
Primary: Healing Evaluation Using Inflammatory-Proliferative-Remodelling Scale (IPR Scale): Inflammatory Phase — 2; 2.49 score on a scale
N/A N=22 Effect of a Novel Reamer-Irrigator-Aspirator on the Incidence of Fat Embolism
Embolism · Femoral Fractures
Primary: Measurement of Embolic Debris — 5.3; 4.05 score on a scale
N/A N=206 OsteoCool Tumor Ablation Post-Market Study
Metastasis Spine · Metastasis to Bone
Primary: Change of Worst Pain Score: Thoracic/Lumbar Spine RF Ablation — -4.1 units on a scale — p=<0.0001
N/A N=120 Assessment of the Safety and the Performance of the SAGITTA EVL R Stems in Hip Arthroplasties
Hip Arthropathy
Primary: Survival Rate of Stems — 94 Percentage of stem unrevised
Phase 3 N=154 Long-term Observational Study of Subjects From Tanezumab Studies Who Undergo a Total Knee, Hip or Shoulder Replacement
Osteoarthritis
Primary: Number of Participants With Surgeon's Assessment of Procedural Difficulty — 9; 49; 8; 66 Participants
Phase 1 N=3 18F-AV-1451 High Resolution Autopsy Study
Alzheimer's Disease
Primary: Relationship of Flortaucipir Scan and Pathology - Whole Cortical Composite Region — 0.429 Correlation coefficient — p=<0.001
Phase 2 N=31 Evaluation of the Use of Trental and Vitamin E For Prophylaxis of Radiation Necrosis
Brain Metastasis
Primary: Number of Participants With Symptomatic Radiation Necrosis — 1 Participants
Phase 4 N=6 Bone Histomorphometry in Postmenopausal Men and Women With Osteoarthritis Undergoing Total Hip Replacement
Osteoporosis
Primary: Percentage of Participants With Modeling Based Bone Formation in the Femoral Neck — 100 percentage of participants
N/A N=13,442 Hemorrhage Risk Prescribed Arixtra
Thrombosis, Venous
Primary: Number of Participants With the Indicated Types of Haemorrhages During Hospitalization or Follow-up for Major Orthopaedic Surgery of Lower Limbs (MOSLL) — 7; 10; 0; 3…
Phase 2 N=10 Low-dose Intra-arterial Bevacizumab for Edema and Radiation Necrosis Therapeutic Intervention (LIBERTI)
Radiation Necrosis
Primary: Change in Radiation Necrosis and Cerebral Edema After a Single Treatment of Low Dose Intra-arterial Avastin (Bevacizumab) — 86.8; 38.6; 32.6; 14.5 cm^3 — p=0.012
N/A N=115 Changes in Knee Articular Cartilage Volume in Women on Aromatase Inhibitors
Arthralgia
Primary: Knee Cartilage Volume — 2042; 1971 mm³