N/A N=101 Gender Difference in Response to Caffeine in Children and Adolescents
Healthy
Primary: Peak Heart Rate After 2 mg/kg of Caffeine — 73.6; 73.2; 79.6 beats per minute — p=<0.05
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=23 Caffeine and Cocaine
Cocaine Dependence
Primary: Visual Analog Scale Subjective Rating of Drug Effects — 8.65; 9.85; 13.65; 10.43 units on a scale
Phase 2 N=30 Caffeinol Hypothermia Protocol
Acute Ischemic Stroke
Primary: Number of Participants With Symptomatic Intracerebral Hemorrhage — 0 participants
N/A N=16 Effect of Oral Caffeine and L-Citrulline Supplementation on Arterial Function in Healthy Males
Hypertension · Healthy
Primary: Aortic Blood Pressure — 5; 6; 4; 4 mmHg — p=<0.001
Phase 4 N=8 A Study to Determine if Caffeine Accelerates Emergence From Anesthesia
Anesthesia
Primary: Waking Time - Re-establishment of the Gag Reflex. — 16.45; 9.57 minutes — p=0.002
N/A N=10 Ketone Production With Acute Caffeine Intake
Healthy Adults
Primary: Plasma Acetoacetate Concentrations — 26.06; 30.99; 32.10 µmol/L
Early Phase 1 N=65 Caffeine and Neurologic Recovery Following Surgery and General Anesthesia
Pain, Postoperative
Primary: Cumulative Opioid Consumption: Postoperative Opioid Consumption, Oral Morphine Equivalents (mg) — 77; 51 oral morphine equivalents (mg) — p=0.092
N/A N=109 Remote Guided Caffeine Reduction
Caffeine Dependence · Anxiety · Sleep Disturbance
Primary: Number of Participants With Treatment Retention as Assessed by Number of Participants With Completed Assessments — 51; 51; 50; 46 Participants
Phase 2 N=41 Efficacy of Caffeine Injection as an Adjuvant to Opioid Therapy in Cancer Pain
Cancer · Pain
Primary: Numeric Rating of Scale (From 0 to 10) of Pain and Possible Side Effects (Drowsiness, Confusion, Nausea) of Opioids — 2.22; 3.10; 2.83; 3.05 scores
Phase 1 N=9 Caffeine for Hypoxic-Ischemic Encephalopathy
Hypoxic-Ischemic Encephalopathy
Primary: Area Under Plasma Concentration-time at Time t (AUC0-t) for Caffeine — 1137.36; 1177.94; 2213.26; 2768.25 mg*hr/L
Phase 4 N=8 A Study to Determine if Caffeine Accelerates Emergence From Propofol Anesthesia
Anesthesia
Primary: Waking Time - Time Between Terminating Anesthesia and Subject Opening Eyes.
N/A N=205 Evaluating the Role of Expectations in Response to Caffeine Consumption: An RCT
Caffeine · Affect · Cognitive Ability, General
Primary: Mood State Score on POMS-2 Test — 2.63; 14.08; 2.19; 2.54 units on a scale
Phase 3 N=98 Effects of Caffeine on Intermittent Hypoxia in Infants Born Preterm
Hypoxia
Primary: Episodes of Intermittent Hypoxia Per Hour — 3.6; 8.4; 3.8; 8.2 Events per hour — p=<0.05
Phase 4 N=21 Early Versus Routine Caffeine Administration in Extremely Preterm Neonates
Caffeine
Primary: Intubation — 3; 7 participants
N/A N=24 Effect of Phytochemicals From Theobroma Cacao on Mental Energy
Mental Fatigue
Primary: Correct Responses on Serial 7 Subtraction Task — 40.91; 42.57; 43.04; 42.13 Correct responses — p=0.05
Phase 2 N=60 Caffeine/Propranolol Intervention for Acute Migraine
Migraine Disorders
Primary: Percentage of Participants Reporting Pain Relief at 2 Hrs Post First Administration of Caffeine/Propranolol (Defined as a Decrease in Headache Pain Intensity From Severe…
Phase 2 N=72 The Effect of Caffeine on Postextubation Adverse Respiratory Events in Children With Obstructive Sleep Apnea (OSA).
Sleep Apnea, Obstructive · Tonsillectomy · Adenoidectomy
Primary: Number of Children Who Developed Postextubation Adverse Respiratory Events Compared to Placebo. — 21; 11 Participants
Phase 2 N=12 Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury
Spinal Cord Injuries
Primary: 10 Meter Walk Time — -5.0; -4.9; -4.6; -5.5 Seconds
Phase 3 N=347 Caffeine's Effect on Regadenoson Administration With Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)
Coronary Artery Disease (CAD)
Primary: Change in Number of Reversible Defects — 0.67; 1.01; 1.00; 0.80 Reversible Defects — p=<0.001
N/A N=16 Acute Effects of Coffee on Appetite and Inflammation Markers, Glucose Metabolism and Energy Intake
Health
Primary: Ghrelin Total Area Under the Curve — 2669; 2593; 2672 ug*h/mL
Phase 2 N=193 Study to Find Out the Optimal Dose of Caffeine in the Combination Tablet of Naproxen Sodium and Caffeine in Patients Experiencing Moderate to Severe Pain After Having Wisdom Teeth Removed
Pain, Postoperative
Primary: Sum of Pain Intensity Difference (SPID) Over 8 Hours — 35.45; 37.87; 30.70; 36.02 Scores on a scale*hours
Phase 1 N=18 Phase 1 Study to Determine the Effects of PBT2 on the Pharmacokinetic Profile of Caffeine
Healthy Volunteers
Primary: Area Under the Plasma Concentration Versus Time Curve (AUC) of Caffeine After a Dose of PBT2 250mg — 32775 ng*hr/mL
N/A N=30 The Effects of e+Shots Energy Beverage on Mental Energy
Caffeine
Primary: Change in POMS Vigor — 9.03; 8.93; 8.80; 9.03 score on a scale
Phase 4 N=74 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine
Apnea of Prematurity · Intraventricular Hemorrhage · Brain Injury
Primary: White Matter Microstructural Maturation — 1.43; 1.42 apparent diffusion coefficient
Phase 4 N=72 Effects of a Common Cold Treatment on Cognitive Function
Common Cold
Primary: Adjusted Mean Change From Baseline in Number of Valid Responses to Rapid Visual Information Processing (RVIP) Cognitive Test — 4.8; 1.3 Valid responses — p=0.0008
Phase 2 N=154 Acute and Residual Effects of Caffeinated Beer
Neurobehavioral Manifestations · Drug Related Sleep Disturbance · Alcohol Intoxication
Primary: Lane Position Deviation — -1.25; -1.36; -1.22; -1.21 feet
N/A N=12 Body Composition Changes With Albuterol and Caffeine Versus Placebo in Adolescents
Pediatric Obesity
Primary: Change in Fat Mass With Caffeine/Albuterol — 0.97; -0.21 kg
Phase 2 N=10 Evaluation of Coffee Therapy for Improvement of Renal Oxygenation
Type1diabetes · Type1 Diabetes Mellitus · Diabetic Kidney Disease
Primary: Renal Oxygenation — 22.4; 22.5 s^-1
N/A N=112 The Effects of Caffeinated Coffee on Intraocular Pressure
Primary Open Angle Glaucoma
Primary: Change in Intraocular Pressure at 60 Minutes — 1.51; 0.52 mm Hg
N/A N=24 Dextro-Amphetamine Versus Caffeine in Treatment-resistant OCD
Obsessive-Compulsive Disorder
Primary: Number of Subjects With Clinical Global Impressions Scale - Improvement (CGI-I) Score of 1 or 2 — 6; 7 participants