N/A N=218 CALERIE: Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy
Aging
Primary: Change in Core Body Temperature, Baseline to 12 Months — -0.05; -0.03 degrees Celsius — p=0.70
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=71 Long-term Caloric Restriction and Cellular Aging Markers
Aging
Primary: Telomere Length — 0.96; 1.06; 1.06; 1.22 ratio
Phase 3 N=164 Calorie Restriction and Changes in Body Composition, Disease, Function, and Quality of Life in Older Adults
Obesity · Diabetes · Hypertension
Primary: Change in Abdominal Fat Mass — -192.6; -21.9; -275 Cubic cm
N/A N=38 Caloric Restriction in Treating Patients With Stage 0-I Breast Cancer Undergoing Surgery and Radiation Therapy
Ductal Breast Carcinoma in Situ · Invasive Ductal Breast Carcinoma · Invasive Lobular Breast Carcinoma
Primary: Number of Participants Who Are Adherent to the Diet Restriction — 28 participants
N/A N=88 Prolonged Daily Fasting as a Viable Alternative to Caloric Restriction in At-Risk Obese Humans
Obesity
Primary: Change in Weight — -3; -3.5; -1.3 Kg
N/A N=15 Effect of Caloric Restriction and Protein Intake on Metabolism and Anabolic Sensitivity
Weight Loss · Starvation
Primary: Change in Resting Metabolic Rate — -63.4; -77.6; -47.4 kcal change
N/A N=39 Effect of Caloric Restriction on Fat Oxidation in Obese Men and Women (Magellan II)
Obesity · Overweight · Metabolic Diseases
Primary: Change From Baseline Amount of Fat Oxidation at 14 Days — 0.91; 0.94 Fold change of RQ ratio
N/A N=100 Alternate Day Fasting for Weight Loss, Weight Maintenance and Cardio-protection
Coronary Heart Disease · Obesity · Weight Loss
Primary: Body Weight — -4.6; -4.5; 0.3 Percent change at month 12
N/A N=33 Time Restricted Eating for Metabolic and Psychological Optimization
Mild Cognitive Impairment · Obesity
Primary: Change in Memory Composite Rank — 6.22 rank — p=<0.001
N/A N=90 Health, Aging and Later-Life Outcomes
Aging
Primary: Number of Participants That Sustained >10% Caloric Restriction — 7; 12 Participants
N/A N=60 Effect of Intermittent Calorie Restriction on MASLD Patients With Abnormal Glucose Metabolism
Fatty Liver Disease · Type 2 Diabetes · Impaired Glucose Regulation
Primary: Change of Liver Fat Content in % — -20.5; -15.5; -7.6; -7.3 absolute fat content change in %
N/A N=48 Influence of Caloric Restriction and Resveratrol in the Sirtuin System in Women and Men Aged 55 to 65 Years
Vascular System Injuries · Lipid Metabolism Disorders · Endothelial Disfunction
Primary: Direct Evaluation of the Sirtuin 1 Gene Expression — 11.04; 11.43; 12.84; 12.05 arbitrary unit relative to control gene
N/A N=105 Protein Supplementation in Elderly With Sarcopenic Obesity Undergoing Caloric Restriction and Exercise
Sarcopenic Obesity · Aging
Primary: Percentage of Fat-free Mass — 49.6; 50.3; 50.5; 52.5 percentage of fat-free mass — p=0.013
N/A N=46 Intermittent Calorie Restriction, Insulin Resistance, and Biomarkers of Brain Function
Alzheimer's Disease · Obesity · Diabetes Mellitus
Primary: Mean Change in Neuron-Derived Extracellular Vesicle (NDEV) Phosphorylated Serine312-insulin Receptor Substrate-1 (pS312-IRS-1) — 79.01; 443.72; -337.70; -608.92 pg/mL
N/A N=50 Calorie-restricted, Ketogenic Diet and Transient Fasting During Reirradiation for Patients With Recurrent Glioblastoma
Recurrent Glioblastoma
Primary: Progression-free-survival — 20; 16 percentage of participants
N/A N=81 Pilot Study of Time Restricted Feeding as a Weight Loss Intervention
Obesity
Primary: Changes in Body Weight — -5.1; -6.2 kg
N/A N=17 TRE With Physical Activity for Weight Management
Pre Diabetes · Overweight and Obesity
Primary: Body Weight Changes Between Week 1 to Week 10 — -2.1; -4.2; -1.3; .1 Percent body weight loss
N/A N=64 TRE in Type 2 Diabetes (See Food Study 3)
Type2Diabetes
Primary: Change in Glycemic Measures- HbA1c (12w) — -0.22; -0.25 percentage of glycated hemoglobin
N/A N=28 Daily Caloric Restriction and Intermittent Fasting in Overweight and Obese Adults With Autosomal Dominant Polycystic Kidney Disease
Polycystic Kidney, Autosomal Dominant
Primary: Feasibility to Enroll and Retain Participants — 122 Participants
N/A N=30 Low-calorie Diet and Body Composition Prior to Roux-en-Y Gastric Bypass
Morbid Obesity · Liver Fat
Primary: Change in Intra-hepatocellular Lipid Content (IHCL) Following the Pre-operative Diet — 40.0; 67.4; 0.1 percentage of change in IHCL
N/A N=29 Time Restricted Eating on Cancer Risk
Pre-diabetes · Breast Cancer · Time Restricted Feeding
Primary: Change in Advanced Glycation End Products (AGE) as Assessed by Plasma — 5.82; 6.38; 5.82; 6.40 ng/mL
N/A N=60 Dietary Carbohydrate Manipulation and Energy Balance: RCT
Physical Activity · Diet Modification
Primary: Physical Activity Energy Expenditure (kJ/Day or kcal/Day) — 1229; 1096; 1275; 1142 kcal/d
N/A N=30 Expression of Longevity Genes in Response to Extended Fasting
Cardiovascular Disease
Primary: Change From Baseline in Participant Glucose When Fasting and Fed — 83.3; -8.0; 5.9 mg/dL
Phase 3 N=80 Hypocaloric Nutrition in Critically Ill Patients
Critically Ill
Primary: SOFA (Sequential Organ Failure Assessment) Score — 0.7; 1.7 units on a scale
N/A N=6 Time Restricted Eating Pilot - Bariatrics
Time Restricted Feeding
Primary: Weight — -.07 kg
N/A N=12 Inflammation and Protein Restriction
Protein Restriction · Diet · Inflammation
Primary: Changes in the Human Intestinal Microbiome That Result From Short Term Dietary Adjustment. — 232; 172; 145; 93 Number of immunity related genes — p=0.05
Phase 4 N=88 Optimizing Body Composition for Function in Older Adults
Obesity · Overweight With Indications for Weight Loss
Primary: Appendicular Non-bone Lean Mass — -2.53; -2.49; -2.04; -1.45 kg
Phase 2 N=34 Effect of mTOR Inhibition and Other Metabolism Modulating Interventions on the Elderly
Aging
Primary: Immunological Responses — 8.33; 11.24 cells/mm^3 — p=0.56
N/A N=32 Impaired Regulation of Energy Balance in Elderly People (Balance Study)
Anorexia of Ageing
Primary: Energy Intake Compensation — 1; 1 MJ/day
N/A N=88 Exercise Intolerance in Elderly Patients With HFpEF(Heart Failure With Preserved Ejection Fraction)
Heart Failure, Diastolic · Obesity
Primary: Peak Exercise Oxygen Consumption (VO2) — 1609; 1653 ml/min — p=0.21