N/A N=77 Minimally Invasive Cardiac Output Monitoring Device
Cardiac Event
Primary: Establishment of a Dataset to Create an Algorithm to Measure Cardiac Output — 75; 2 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=33 Noninvasive Measurement of CO Using Impedance Cardiography in Patients With CHD
Congenital Heart Disease
Primary: Mean Difference in Stroke Volume Between CMR and SMIC — 1.7 ml — p=0.47
N/A N=22 Endothelial Function and Cardiac Output in RV Pacing
Bradycardia
Primary: Endothelial Function Assessed by Flow Mediated Vasodilatation — 1.96; 1.73 EndoPAT index (EnFI)
N/A N=89 Pediatric Cardiac Output Monitoring Observational Study
Pediatric ALL
Primary: Bias of FloTrac Arterial Pressure Cardiac Output (L/Min) Against Swan Ganz Invasive Cardiac Output — 0.49 L/min
N/A N=39 Clinical Evaluation of Cardiac Output Estimation Based on Pulse Wave Transit Time
Myocardial Infarction · Myocardial Ischemia
Primary: esCCO (Estimated Continuous Cardiac Output) Monitor — 5.6 liters/minute
N/A N=60 Ninvasive Cardiac Output Measurements During Cesarean Delivery Under Spinal Anesthesia.
Hypotension During Cesarean Delivery · Spinal Anesthesia
Primary: Percentage of Participants With a Cardiac Output Within and Outside 20% of Baseline Values — 71; 66; 29; 34 percentage of patients — p=0.37
Phase 1 N=20 Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study
Septic Shock
Primary: Standing Dose of Norepinephrine Which is Required to Maintain a Mean Arterial Pressure (MAP) of 65 mmHg - Hour 1 — 7.4; 27.6 mcg/min
Phase 2 N=18 Corticosteroids in Postoperative Critically Ill Neonates With Low Cardiac Output Syndrome With Congenital Heart Disease
Cardiac Output, Low
Primary: Blood Pressure. — 6; 5.89 mmHg
Phase 2 N=10 Coenzyme Q10 in Post-Cardiac Arrest Cerebral Resuscitation
Cardiac Arrest · Sudden Cardiac Arrest
Primary: Prevalence of Low Serum CoQ10 Levels in Cardiac Arrest Patients — 0.706; 0.66 ug/mL
N/A N=27 Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study)
Transposition of the Great Vessels · Hypoplastic Left Heart Syndrome · Oxygen Consumption Based Assessment of Hemodynamics
Primary: Oxygen Consumption — 72; 102 mL oxygen/min/m^2
N/A N=60 Blood Flow Regulation in Individuals With Down Syndrome - Training Study
Down Syndrome
Primary: Change From Baseline Work Capacity at 13 Weeks — -1.20; -0.18 change in ml/kg/min — p=0.660
Phase 3 N=26 24 Hour Ambulatory Cardiac Oxygen Consumption
Hypertension
Primary: ACRPP: 24-hour Ambulatory Central Rate-pressure Product (Also Called TTI, CTTI) — 2531; 2824; 2484 mmHg*beats/min — p=0.05
Phase 2 N=90 Low Dose Continuous Furosemide Effect on Cardiac Surgery Patients With Kidney Dysfunction
Chronic Kidney Disease · Cardiac Disease
Primary: Glomerular Filtration Rate at Baseline — 56; 67 mL/mnt/1.73 m^2
N/A N=10 Blood Volume and Fluid Kinetics in Patients Undergoing Extracorporal Circulation
Blood Volume, Extravasation
Primary: Blood Volume — 4.61 Litre
Phase 4 N=55 Evaluation of Arterial Pressure Based Cardiac Output for Goal-Directed Perioperative Therapy
Esophageal Diseases · Gastrointestinal Diseases · Disorder of the Genitourinary System
Primary: Length of Hospital Stay (LOS) by Participant
Phase 4 N=17 Descriptive Study of Cardiac Output During Rehydration With Recombinant Human Hyaluronidase in Pediatrics
Dehydration · Cardiac Output · Pediatrics
Primary: Cardiac Output Trends
Phase 3 N=261 Impedance Cardiography: Clinical Evaluation of Endotracheal Cardiac Output Monitor (ECOM)
Cardiac Output
Primary: Comparison of ECOM Impedance and Thermodilution Cardiac Output Measurements — 0.31 liters/min
N/A N=15 Right Ventricular Function and Exercise Capacity in Patients With Continuous-flow Left Ventricular Assist Devices
Heart Failure
Primary: Peak Oxygen Uptake — 15 ml/kg/min
Phase 4 N=76 Cardiovascular Function in COPD Patients
Pulmonary Disease, Chronic Obstructive
Primary: Change From Baseline in Left Ventricular End Diastolic Volume Index (LVEDVI) in the 6th Week of Treatment — 2.855; 2.317 Millilitre/ meter^2 (mL/m^2) — p=0.6331
Phase 2 N=58 Natriuretic Peptide System as Therapy in Human Preclinical Left Ventricle Dysfunction
Congestive Heart Failure
Primary: Change in Natriuresis (Urinary Sodium Excretion) in Control Subjects at 60 Minutes After Volume Expansion Compared to Baseline in Response to Placebo Treatment — 87.19…
N/A N=13 Effect of Chronic Changes in Heart Rate on Congestive Heart Failure
Heart Failure, Congestive
Primary: Ejection Fraction — 33; 30; 25 % of blood ejected with each beat
N/A N=11 Hypoglycemia (Low Blood Sugar) and the Heart
Hypoglycemia · Type 2 Diabetes
Primary: Number of Participants With Hypoglycemia (Blood Sugar Level <70 mg/dl — 11 Participants
N/A N=18 Renal Perfusion, Filtration and Oxygenation During Cardiopulmonary Bypass (CPB)
Complication of Extracorporeal Circulation · Renal Impairment
Primary: Renal Blood Flow (RBF) — 554; 524; 564; 558 ml per minute per 1.73 m2 body surface — p=0.638
Phase 2 N=157 A Dose-ranging Trial of OPC-131461 in Cardiac Edema (Congestive Heart Failure [CHF])
Cardiac Edema (CHF)
Primary: Change in Body Weight From Baseline to Last Assessment Time Point (the Day After IMP Administration) by Day 8 — -1.96; -1.74; -1.4; -1.84 kg
Phase 3 N=121 Heart Rate Reduction in Heart Failure
Heart Failure
Primary: Exercise Tolerance Assessed by 6 Minute Walking Test — 474.8; 435.7; 453.1 meters
Phase 4 N=42 Levosimendan Efficacy Assessment by Cardiopulmonary Exercise Test (CPET)
Heart Failure
Primary: Change in Peak VO2 (Oxygen Consumption ) — 1.21; 0.48 ml/kg/min
Phase 3 N=20 A Clinical Pharmacological Study of OPC-41061 in the Treatment of Cardiac Edema (Congestive Heart Failure)
Cardiac Edema
Primary: Body Weight — -1.68; -2.14 Kg
N/A N=22 Microcirculatory Perfusion in Patients With Coma After Out-of-hospital Cardiac Arrest
Cardiac Arrest
Primary: Microvascular Flow Index (MFI) — 1.7; 1.1 units on a scale
Phase 2 N=21 The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury
Spinal Cord Injury · Autonomic Dysreflexia · Baroreceptor Integrity
Primary: Systolic Blood Pressure — 93.21; 107.00; 95.8; 93.84 mmHg
Phase 3 N=52 A Study of OPC-41061 in Subjects With Cardiac-induced Edema (Congestive Heart Failure)
Cardiac Edema
Primary: Body Weight — -2.05; -1.31; -2.9 Kg