Phase 2 N=31 NeuroCognition After Carotid Recanalization
Cognition Disorder · Stroke · Occlusion Carotid
Primary: Change in Montreal Cognitive Assessment (MoCA) Score — 0.56; 1.38; -0.75; 0.50 score on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=217 Evaluate Carotid Artery Plaque Composition by Magnetic Resonance Imaging in People Receiving Cholesterol Medication
Coronary Artery Disease · Carotid Artery Diseases · Atherosclerosis
Primary: Annualized LRNC Volume Change in Carotid Plaque Composition, as Assessed by MRI — -4.6; -15.1; -9.4 mm^3/year
Phase 2 N=54 New Technologies to Determine Carotid Plaque Vulnerability in Patients With Significant Carotid Plaques
Carotid Artery Plaque
Primary: Number of Subjects Who Completed All of the Ultrasound Examinations — 17; 37 Participants
N/A N=129 Optical Coherence Tomography Angiography Evaluation of Ocular Changes in Patients With Carotid Artery Stenosis
Carotid Stenosis
Primary: Radical Peripapillary Capillaries Vessel Density — 55.95; 57.24 percentage of vessel
N/A N=170 Asymptomatic Carotid Stenosis: Cognitive Function and Plaque Correlates
Cognitive Manifestations
Primary: Composite Cognitive Score — 45.5; 47.9 units on a scale
Phase 3 N=211 Carotid and Vertebral Magnetic Resonance Angiography (MRA) Study Comparing Dotarem and Time Of Flight (TOF)
Cerebral Arterial Diseases
Primary: Technical Failure Rate — 3.55; 29.22; 1.57; 17.65 percentage of arterial segments
Phase 3 N=222 Carotid and Vertebral Magnetic Resonance Angiography (MRA) Study Comparing Dotarem and Time Of Flight (TOF)
Cerebral Arterial Diseases
Primary: Technical Failure Rate — 4.65; 29.44; 1.77; 16.70 percentage of arterial segments
N/A N=2,502 Carotid Revascularization Endarterectomy Versus Stenting Trial
Atherosclerosis · Stroke · Carotid Stenosis
Primary: Any Periprocedural Stroke, Myocardial Infarction, or Death During a 30-day Peri-procedural Period, and Postprocedural Ipsilateral Stroke Thereafter, up to 4-years…
N/A N=230 Additional Neurological Symptoms Before Surgery of the Carotid Arteries - A Prospective Study (ANSYSCAP)
Carotid Stenoses
Primary: Ipsilateral Ischemic Stroke Before Carotid Endarterectomy — 33 participants
N/A N=125 Non-invasive Computer-Aided Phenotyping of Vasculopathy
Carotid Atherosclerosis · Peripheral Arterial Disease
Primary: Measurement Bias of Calcification Analyzed by vascuCAP™ Non-invasively Relative to Histopathology as Ground Truth. — -0.47; .07 mm2
Phase 2 N=6 TRACER [F-18] RDG-K5 Carotid Plaque Imaging Study
Carotid Arteries
Primary: Uptake of [F-18] RGD-K5 by Carotid Plaque With PET/MRI Imaging in the Artery Believed to be the Cause of Transient Ischemic Attack (TIA) or Stroke Symptoms Compared to…
N/A N=322 Protected Carotid Artery Stenting in Subjects at High Risk for Carotid Endarterectomy (CEA) (PROTECT)
Carotid Artery Disease
Primary: Kaplan-Meier Estimate of Freedom From the Composite of Any Death, Stroke and MI During the 30 Day Post Procedural Period (DSMI), Plus Fatal and Non-fatal Ipsilateral…
N/A N=1,500 Carotid Revascularization With ev3 Arterial Technology Evolution Post Approval Study
Carotid Artery Disease
Primary: Composite Rate of Death, Ipsilateral CVA, Procedure-related CVA, or Myocardial Infarction (MI) at 30 Days Post-procedure. — 99 participants
N/A N=230 CorMatrix ECM for Carotid Repair Following Endarterectomy Registry
Carotid Stenosis
Primary: Carotid Procedure and Device Related Adverse Events to Determine Device Performance — 53; 10; 1; 2 Device related adverse events
N/A N=126 Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke Patients
Cerebrovascular Accident · Moyamoya Disease
Primary: Percentage of Regions With Collateral Versus Antegrade Blood Flow (Sensitivity) Correctly Identified Using MRI With Xenon Contrast Agent (Specificity) — 81.7; 88.9…
N/A N=12,012 Vascular Ultrasound Screening in Patients With Ischemic Cerebrovascular Disease: a Multi-center Registry Study
Stroke
Primary: Evidence of Carotid Artery or Intracranial Artery Atherosclerosis Confirmed by Vascular Ultrasonography — 96; 1063; 826; 241 artery numbers
Phase 3 N=486 ViVEXX Carotid Revascularization Trial (VIVA)
Carotid Artery Stenosis
Primary: Percentage of Patients Experiencing Major Adverse Events (MAE) — 6.9 percentage of participants
N/A N=817 Neuropsychometric Outcome After Carotid Endarterectomy
Carotid Artery Stenosis · Carotid Artery Disease · Transient Ischemic Attack
Primary: Percentage of Patients Having a Significant Change in Neuropsychometric Performance After Carotid Endarterectomy — 22; 4.5 percentage of participants
N/A N=55 The ENROUTE Transcarotid Neuroprotection System (ENROUTE Transcarotid NPS) DW-MRI Evaluation
Carotid Artery Diseases · Carotid Atherosclerosis · Carotid Stenosis
Primary: Incidence of Ipsilateral New White Lesions, by Patient — 12 Participants
N/A N=2 Pilot Study of Pre-Ischemic Conditioning for Intracranial Atherosclerosis
Intracranial Atherosclerosis
Primary: Percent Change in Cerebral Blood Flow (CBF) — 0; 25 percentage increase in CBF
Phase 3 N=225 Diagnosis and Treatment of Sleep Apnea in Cerebrovascular Disease
Obstructive Sleep Apnea · Stroke · Transient Ischemic Attack
Primary: Sleep Apnea Diagnosis Rate — 58; 5 participants
N/A N=200 Bacteria in Atherosclerotic Plaques and Adverse Events
Carotid Artery Stenosis · Cerebral Infarction · Diabetes
Primary: Analysis of Bacterial Types in Plaques — 2.2; 0.58 percentage
N/A N=52 Surgical Indirect Revascularization For Symptomatic Intracranial Arterial Stenosis
Intracranial Arterial Stenosis · Intracranial Atherosclerosis · Ischemic Stroke
Primary: Stroke or Death in the Territory of Qualifying Artery — 5 Participants — p=0.08
Phase 2 N=120 Effect of Valsartan on Carotid Artery Disease
Carotid Artery Diseases · Atherosclerosis
Primary: Change in the Mean Vessel Wall Area (VMA) of the Carotid Bulb From Baseline to 2 Years — -6.7; 3.4 mm2
N/A N=75 Silk Road Medical First in Man Study - Neuroprotection During Carotid Stenting and Angioplasty
Carotid Artery Diseases
Primary: Safety Evaluation as Composite of Occurrences of Major Stroke, Myocardial Infarction and Death — 0; 0; 0 Occurences
Phase 2 N=189 Protective Effects of Long-term Remote Limb Ischemic Preconditioning For Carotid Artery Stenting
Carotid Artery Stenosis
Primary: Number of Patients With Cerebrovascular Events, Cardiovascular Events or Death. — 0; 2; 2; 1 participants
N/A N=1,147 Carotid Structure and Function in MPS Syndromes: A Multicenter Study of the Lysosomal Disease Network
Mucopolysaccharidoses
Primary: Carotid Intima-media Thickness, Measured in Millimeters — 0.44; 0.52; 0.56 mm
Phase 2 N=158 Revacept in Symptomatic Carotid Stenosis
Carotid Stenosis · Atherosclerosis · Stroke
Primary: New DWI Lesion(s) — 1.2; 1.0; 0.6 Number of new lesions
Phase 3 N=219 Safety and Efficacy Study for Reverse Flow Used During Carotid Artery Stenting Procedure
Carotid Artery Disease
Primary: Hierarchical Composite of Stroke, Myocardial Infarction, and Death — 8 Participants
N/A N=312 The Gore SCAFFOLD Clinical Study
Carotid Artery Disease · Carotid Artery Stenosis
Primary: Number of Participants Who Experienced Major Adverse Events (MAE) at One Year — 11 Participants — p=<0.00001