N/A N=53 Multifactorial Approach to Emergent Cerclage
Cervical Insufficiency
Primary: Gestational Latency Achieved Between Cerclage Placement and Time of Delivery — 80; 97 days — p=0.018
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=385 Prevention of Preterm Birth Using Cervical Pessary in Pregnant Women With Short Cervix
Preterm Birth
Primary: Spontaneous Delivery Before 34 Completed Weeks — 51; 12 Participants
Phase 3 N=465 PREGNANT Short Cervix Trial
Preterm Delivery · Short Cervix · Short Uterine Cervical Length
Primary: Number of Participants With Birth <=32 6/7 Weeks Gestation. — 36; 21 participants — p=0.020
N/A N=168 Short Term Comparison of Two Different Techniques of Uterine Cesarean Incision Closure
Cesarean Section Complications
Primary: Cesarean Scar Defect in the Uterine Incisional Line — 12; 39 participants — p=0.0001
N/A N=168 Long Term Comparison of Two Different Techniques of Uterine Cesarean Incision Closure
Cesarean Section; Complications · Placenta Previa · Placenta Accreta
Primary: Placenta Previa — 18; 17; 0; 3 Participants
N/A N=20 Cervix Monitor for Elasticity and Length Measurements
Preterm Birth
Primary: Cervix Elasticity — 54; 19.7 kPa
Phase 2 N=271 Efficacy Study of a Cervical Pessary Containing Progesterone for the Prevention of Preterm Delivery
Preterm Birth
Primary: Number of Participants Not Giving Birth Before Week 32 and Week 34 of Gestation — 73; 71; 67; 66 Participants
N/A N=144 Balloon Catheter for Cervical Ripening
Cervical Dilation
Primary: Duration — 16.2; 16.9 hours — p=0.814
N/A N=19 NHLBI DIR Transcatheter Mitral Cerclage Annuloplasty Early Feasibility Study
Functional Mitral Regurgitation
Primary: The Primary Endpoint is Technical Success — 17 Participants
N/A N=282 Single or Double-layer Uterine Closure Techniques
Uterine Scar · Cesarean Section Complications · Cesarean Section; Dehiscence
Primary: Number of Participants With Niche Visualized by Saline Infusion Sonography — 40; 53; 25; 23 Participants — p=0.05
Phase 3 N=1,311 A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix
Short Cervical Length
Primary: Number of Participants With Delivery or Fetal Loss of Either Twin Prior to 35 Weeks Gestation — 84; 84; 86 Participants
N/A N=89 Paracervical Versus Intracervical Lidocaine
Abortion, Induced · Pain
Primary: Pain Score, as Assessed Using a 10 cm Linear Visual Analog Scale (VAS) — 4.25; 3.97 units on a scale
N/A N=60 Severing Nuchal Cord at the Time of Delivery.
Perinatal Outcome
Primary: Umbilical Cord pH — 7.29; 7.32 pH — p=0.1
Phase 4 N=10 Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage
Cervical Incompetence
Primary: Duration of Motor Block — 75; 99 minutes
N/A N=80 Modifying Cervical Bishop Scoring System
Failed Induction of Labor
Primary: Area Under Receiver Operating Characteristic Curve (ROC) for Modified Bishop Score — 0.916 probability — p=0.000
N/A N=46 Prevention of Preterm Birth With a Pessary in Twin Gestations
Premature Birth · Short Cervix
Primary: Number of Participants With Preterm Delivery — 9; 8 Participants
N/A N=197 Foley Bulb Traction for Cervical Ripening
Cervical Ripening · Induction of Labor
Primary: Time to Delivery — 19.8; 18.8 hours
N/A N=100 Foley Catheter Compared to the Foley Catheter Alone for Cervical Ripening
Cervical Ripening · Induction of Labor
Primary: The Median Times From Placement of Foley Catheter to Vaginal Delivery — 21.2; 31.3; 17.1; 14.8 hours
N/A N=122 Prevention of Preterm Birth With a Pessary in Singleton Gestations
Preterm Birth · Short Cervix
Primary: Number of Subjects Experiencing Preterm Birth — 26; 23 Participants
N/A N=300 Cervical Preparation Before Dilation and Evacuation
Abortion, Induced
Primary: Operative Time — 6.27; 6.28; 5.53 minutes
N/A N=32 Transcervical Balloon Compared to Osmotic Dilators Prior to Surgical Abortion
Abortion, Second Trimester
Primary: Procedure Time — 22.4; 22.6 minutes
Phase 4 N=236 Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial
Obesity · Labor Induction · Cesarean Delivery
Primary: Number of Participants With a Need for Cesarean Delivery — 51; 53 Participants
N/A N=230 Cervical Ripening in Premature Rupture of Membranes
Pregnancy · Premature Rupture of Membranes · Preterm Premature Rupture of Membranes
Primary: Rate of Cesarean Section — 27; 26; 89; 86 participants — p=0.99
N/A N=129 Evaluation of CRB in PROM Patients
Premature Rupture of Fetal Membranes
Primary: Time of Labor — 850.4; 1016.6 Minutes
Phase 4 N=7 Intrauterine Contraceptive Device (IUD) Placement at Time of C-Section
Contraception
Primary: Successful Retention of IUD — 7 participants
Phase 4 N=47 ED90 of 3% Chloroprocaine for Cervical Cerclage
Cerclage, Cervical
Primary: The Dose of Intrathecal (IT) Chloroprocaine That Provides Effective Anesthesia in 90% of Patients Undergoing Elective Cerclage Placement (Intraoperative Analgesic…
N/A N=279 Tension Versus Tension- Free Foley Balloon for Cervical Ripening
Induced Vaginal Delivery
Primary: Time to Vaginal Delivery — 1608; 1595.5 minutes
N/A N=226 Barbed Suture for Hysterotomy Closure During Cesarean Section
Hysterotomy
Primary: Quantitative Blood Loss — 641.8; 596.5 mL
N/A N=204 Cervical Ripening With a Double-lumen Balloon Catheter for Six Versus Twelve Hours
Induction of Labor Affected Fetus / Newborn
Primary: Time From Foley Bulb Placement to Time of Delivery. — 24.2; 24.57 hr — p=0.8
N/A N=102 Comparison of Pre-Induction Cervical Ripening
Failed Labour
Primary: Vaginal Delivery — 20; 21; 20 participants