Clinical Trial Search

Primary: Number of Subjects With Daily Headache Who Have Continuous Headache — 18; 27 participants

Primary: Reduction in Headache Intensity — 6; 4; 1; 3 Participants

Primary: Pain Intensity — 5.82; 4.92 score on a scale

Primary: Number of Participants Who Report Moderate or Severe Pain Within 24 Hours of Emergency Department(ED) Discharge — 53; 6; 20 Participants

Primary: Persistent Headache Pain Free at 24 Hours — 26; 19 Participants

Primary: Percentage of Participants With Episodic Migraine (EM) or Chronic Migraine (CM) — 91.2; 8.8 percentage of participants

Primary: Presence or Absence of Prophylactic Medication for Headache/Migraine — 166; 227; 18; 48 Participants

Primary: Comparison of the Headache Pain Free Attack Rates at 15 Minutes Following the Treatment — 495; 400; 67; 46 Number of attacks

Primary: Change in Headache Days/Month After 4 Years Compared to Baseline — 6.6 headache days/month

Primary: Change in the Number of Moderate to Severe Headache Days Within a 28 Day Average Period in Six Months Compared to Baseline — 4.4; 4.7 Moderate to severe headache days…

Primary: Migraine Functional Impairment as Measured by Score on the Headache Impact Test 6 (HIT6) Scale — 59; 56 units on a scale

Primary: Number of Participants With Treatment-emergent Adverse Events (AEs) — 106 Participants

Primary: Headache Days as Self-reported by Participants — 3.0; 3.3 days

Primary: A Change in the Frequency of Cluster Headache Attacks Per Week — -2.0; -7.6 CH attacks per week

Primary: Headache Severity as Measured on an 11-point Verbal Scale (0 to 10):0=No Pain 10=Excruciating Pain — -3.29; -3.70 units on a scale — p=<0.01

Primary: Percentage of Participants Admitted to the Hospital for Headache — 6.0; 2.1 percentage of participants

Primary: Change in Frequency of Migraine Days During the Last 28 Day Interval of the Treatment Period as Compared to the 28 Day Baseline Period. — 4.5 days

Primary: Headache-related Disability Scores on the Headache Impact Test 6 (HIT-6) — 66.1; 66.1; 65.2; 61.9 score on a scale — p=<0.001

Primary: Number of Headache Days at 3 Months — 18.17; 19.19; 16.47; 18.26 headache days — p=0.61

Primary: Percentage of Subjects Who Achieve Pain Relief — 3; 5; 5 Participants

Primary: Frequency of Headaches — 10 Participants — p=.101

Primary: Change in Number of Headache Days Per Month From Baseline (BL) to Months 1 Through 7. — -7.61; -6.67; -9.72; -5.22 days

Primary: Change in Pain Score — 3.8; 5.1 units on a scale

Primary: Change in Headache Relief — 23 percentage of headaches resolved — p=.079

Primary: Adherence to Acute Migraine Management Strategies: Treat Early — 0; 2 Participants

Primary: Change From Baseline in the Number of Weekly Cluster Headache (CH) Attacks, Averaged Over Weeks 1-2 — -4.0; -4.6 Number of Weekly Attacks — p=0.5048

Primary: Time to Relief (Min) — 92.2; 83.9; 35.4 Minutes

Primary: Frequency of Moderate or Severe Headache After Emergency Department (ED) Discharge — 31; 29; 42; 44 Participants — p=0.751

Primary: Overall Mean Change From Baseline in Weekly Cluster Headache Attack Frequency — -4.59; -5.38 cluster headache attacks per week — p=0.334

Primary: Change in Pain Score at 60 Minutes — 4; 5 score on a scale