Phase 4 N=32 A Study on the Safety of Tranexamic Acid for the Chronic Subdural Hematoma Population
Subdural Hematoma
Primary: Number of Participants With Medication Related (Thromboembolic) Complications — 0 Participants
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N/A N=376 Middle Meningeal Artery Embolization for the Treatment of Subdural Hematomas With TRUFILL® n-BCA
Chronic Subdural Hematoma
Primary: Residual or Re-accumulation of the Chronic Subdural Hematoma (cSDH) (Greater Than [>] 10 Millimeter [mm]) as Assessed by an Independent Core Laboratory OR Any…
N/A N=500 Assessment of InfraScanner 2000™ in Detecting Subdural and Epidural Hematomas
Head Trauma · Craniocerebral Injuries · Crushing Skull Injury
Primary: Sensitivity of InfraScanner 2000 TM to Detect Any Size Hematoma at the Patient Level — 85.6 percentage
N/A N=672 Assessment of InfraScanner 2000™ in Detecting Subdural and Epidural Hematomas
Head Trauma · Craniocerebral Injuries · Crushing Skull Injury
Primary: Number of Participants With Detection of Hematoma Stratified by CT Positive and CT Negative Status — 158; 22; 126; 81 Participants
Phase 1 N=62 Delayed Versus Early Enoxaparin Prophylaxis After Traumatic Brain Injury (TBI)
Venous Thromboembolism · Traumatic Brain Injury
Primary: Percentage of Participants With Worsening TBI Hemorrhage — 5.9; 3.6 percentage of participants
N/A N=37 Ventriculostomies in SAH: ICP Open or Not?
Subarachnoid Hemorrhage
Primary: Cerebral Artery Vasospasm — 16; 7 Participants
Phase 2 N=8 Poststroke Depression in Hemorrhagic Stroke
Stroke Hemorrhagic · Depression
Primary: Depression — 12.33; 6 units on a scale
N/A N=400 Investigation of Clot in Ischemic Stroke and Hematoma Evacuation
Ischemic Stroke · Intracranial Hematoma
Primary: Clot Specimen Histology — 373; 12 Count of specimen
Phase 3 N=499 Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III
Intracerebral Hemorrhage
Primary: Dichotomized, Adjudicated Modified Rankin Scale Score 0-3 vs. 4-6 at 365 Days Post Ictus (Adjusted) — 110; 100; 139; 140 Participants — p=0.73
N/A N=162 Posterior Fossa Decompression With or Without Duraplasty for Chiari Type I Malformation With Syringomyelia
Arnold-Chiari Malformation, Type 1 · Chiari Malformation Type I · Type I Arnold-Chiari Malformation
Primary: The Number of Participants With Surgical Complications — 8; 10 Participants
N/A N=6 Deep Brain Stimulation for the Treatment of Traumatic Brain Injury
TBI (Traumatic Brain Injury)
Primary: Percent Change in Trail Making Test Part B Time to Completion — -25.6 percent change in time
N/A N=45 Do Patients With Chronic Daily Headache Have Continuous Headache or Moments of Headache Relief?
Chronic Daily Headache
Primary: Number of Subjects With Daily Headache Who Have Continuous Headache — 18; 27 participants
N/A N=180 Detecting Traumatic Intracranial Hemorrhage With the InfraScanner 2500™ in Uganda
Head Trauma · Crushing Skull Injury · Head Injury
Primary: Infrascanner 2500™ Diagnostic Performance — 79; 65; 27; 9 Participants
N/A N=40 Transcranial Direct Current Stimulation for the Treatment of Deficits After Traumatic Brain Injury
Traumatic Brain Injury · Post Concussive Symptoms · Depression
Primary: Examiner Score — 0.617; 0.907; 0.865; 1.155 score on a scale
N/A N=800 Validation of Falls Decision Rule to Exclude Intracranial Bleeding in Geriatric Fall Patients
Intracranial Hemorrhages
Primary: Number of Participants With the Clinically Important Intracranial Bleeding — 48; 1 Participants
Phase 2 N=294 Intracerebral Hemorrhage Deferoxamine Trial - iDEF Ttrial
Intracerebral Hemorrhage
Primary: Proportion of Patients With Modified Rankin Scale (mRS) Score 0-2 at 90 Days — 48; 47 Participants
Phase 3 N=500 Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III
Intraventricular Hemorrhage
Primary: Participants With Modified Rankin Scale (mRS) <=3 - Dichotomized Analysis — 47.6; 44.9 percentage of participants — p=0.554
Phase 2 N=62 Transcranial Direct Current Stimulation in Patients With Disorders of Consciousness
Vegetative State · Minimally Conscious State · Disorders of Consciousness
Primary: Change in CRS-R Total Scores — 12.17; 10.60 units on a scale
N/A N=26 Noninvasive Brain Stimulation on Memory in Individuals With Mild Cognitive Impairment and History of Brain Injury
Amnestic Mild Cognitive Impairment · Traumatic Brain Injury · Mild Traumatic Brain Injury
Primary: Hopkins Verbal Learning Test-Revised Total Learning — 35.8; 35.9; 34.2; 31.6 T-score on a scale
Phase 2 N=31 Safety Study of Dantrolene in Subarachnoid Hemorrhage
Subarachnoid Hemorrhage · Cerebral Vasospasm
Primary: Hyponatremia — 7; 10 participants
N/A N=15 Cerebral Blood Flow During Hemodialysis
Haemodialysis-induced Symptom
Primary: Change in CBF From Baseline (Before Start of the Hemodialysis Study Session), at 20 Minutes, and at the End of the Hemodialysis Study Session, Measured by [15O]H2OPET-CT…
Phase 4 N=162 Dexamethasone for Post Traumatic Headache
Post-Traumatic Headache
Primary: Frequency of Moderate or Severe Headache After Emergency Department (ED) Discharge — 31; 29; 42; 44 Participants — p=0.751
N/A N=105 Study of SyntheCelTM Dura Replacement to Other Dura Replacements
Cranial Dura Repair
Primary: Absence of Cerebrospinal Fluid (CSF) Fistula and Pseudomeningocele — 57; 33 participants
Phase 2 N=52 Clinical Trial on Treatment of Intraventricular Hemorrhage
Intraventricular Hemorrhage
Primary: 30-day Mortality — 1; 1; 6 Number of participants
N/A N=431 A Multi-Center Study of Near-Infrared Spectroscopy (NIRS) for Hematoma Detection
TBI (Traumatic Brain Injury)
Primary: 1) Sensitivity of the Near-Infrared Spectroscopy (NIRS) Measurements for Identifying Intracranial Hematomas Due to Trauma. 2) Specificity of the Near-Infrared…
N/A N=971 Shared Decision Making in Parents of Children With Head Trauma: Head CT Choice
Head Injury
Primary: Assess Parents' Knowledge Regarding Their Child's Risk for a Significant Brain Injury — 6.2; 5.26 Number of questions correct out of 10
N/A N=236 MIND: Artemis in the Removal of Intracerebral Hemorrhage
Cerebral Hemorrhage · Brain Hemorrhage · Cerebral Parenchymal Hemorrhage
Primary: Global Disability (Functional Outcome) Assessed Via the Ordinal Modified Rankin Score (mRS) — 32; 20; 4; 2 Participants
N/A N=52 Surgical Indirect Revascularization For Symptomatic Intracranial Arterial Stenosis
Intracranial Arterial Stenosis · Intracranial Atherosclerosis · Ischemic Stroke
Primary: Stroke or Death in the Territory of Qualifying Artery — 5 Participants — p=0.08
Phase 2 N=42 Statins and Cerebral Blood Flow in Subarachnoid Hemorrhage (SAH)
Subarachnoid Hemorrhage
Primary: Resting Cerebral Blood Flow During Peak Period of Vasospasm Risk — .34; .30 mL/100 g/min
Phase 2 N=163 Study of Modified Stem Cells (SB623) in Patients With Chronic Motor Deficit From Ischemic Stroke
Chronic Ischemic Stroke
Primary: Proportion of Subjects Whose Fugl-Meyer Motor Total Score (FMMS) Improved by ≥ 10 Points at Month 6 From Baseline — 7; 9; 7; 46 Participants — p=0.6743