N/A N=40 Mindfulness for Resilience in Early Life
Adolescent With Early Life Stress · Resilience
Primary: Cortisol Reactivity — -0.21; 0.34; 0.05; -0.08 μg/dL — p=<.05
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=102 Pilot Study Assessing Oxidative Stress in Children
Adrenal Insufficiency · Critical Illness
Primary: Pediatric Logistic Organ Dysfunction Score in Critically Ill Children — 15.9 scores on a scale
N/A N=23 Stress and the Nervous System
Autonomic Nervous System · Baroreflex · Stress, Physiological
Primary: Cardiovagal Baroreflex Sensitivity (Modified Oxford Technique) — 17.75; 16.90; 14.42; 17.27 ms/mmHg
N/A N=170 Stressor-evoked Brain and Cardiovascular Responses to Acute Psychological Stress
Acute Psychological Stress
Primary: Stressor-evoked Oxygen Consumption in mL/(kg·Min) (Stress - Baseline) — 0.265; 0.287 mL/(kg·min)
N/A N=119 Stress Response in Opioid Use Disorder
Opioid-use Disorder
Primary: Change in Negative Affect — 1.67; 1.25; 3.60 scores on a scale
Phase 1 N=20 Oxytocin, Stress, Craving, Opioid Use Disorder
Opioid Use Disorder
Primary: Opioid Craving — 21.6; 22.4; 23.3; 23.4 score on a scale
N/A N=6 Combined Effects of Prolonged Sitting and Mental Stress on the Cardiovascular System
Sedentary Behavior · Cardiovascular Risk Factor · Mental Stress
Primary: Mean Change in Brachial-femoral Pulse Wave Velocity (bfPWV) — -0.26; 0.22 m/s
N/A N=94 Stress and the Sympathetic Nervous System in Adults With Depression
Major Depressive Disorder
Primary: Percent of Days Participants Report Stressors — 36; 40 percent of days
Phase 4 N=226 Stress Neuroadaptation in Tobacco Dependence
Nicotine Dependence
Primary: Overall Stressor Reactivity — 25.1; 22.5; 32.3; 16.9 microvolts
N/A N=17 Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive Decline
Middle-aged Adults · Major Depressive Disorder
Primary: Nitric Oxide (NO)-Mediated Endothelium-dependent Dilation (EDD) — 70; 74 percentage — p=>0.05
N/A N=42 HEALTHY (Health Education Adolescent Leadership Training to Help Youth) Leaders
Stress
Primary: Number of Participants Reporting Pediatric Symptoms as Assessed by the Pediatric Symptom Checklist-17 (PSC-17) — 3; 2; 4; 3 participants
N/A N=50 Stress and CKD Among African Americans
Chronic Kidney Disease
Primary: Change in Subjective Units of Distress Scale (SUDS) Score — 2.92; 3.12 score on a scale
N/A N=217 Breathe With Ease: A Unique Approach to Managing Stress (BEAMS)
Asthma
Primary: Symptom-free Days in the Last 14 Days — 11.4; 11.6 days in prior 14d — p=0.93
N/A N=270 The Biology of Resilience
Oxytocin · Placebo
Primary: Systolic Blood Pressure Change From Baseline to Second Stress Task Experience - Autonomic Stress Response Measure — 9.4; 12.9; 11.3; 11.1 mm Hg — p=0.03
N/A N=199 Caregiver Self-Management of Stress
Caregiver Distress · Job Stress
Primary: 10-item Kessler Psychological Distress Scale (K10) — 23.38; 23.79 score on a scale — p=0.513
N/A N=72 Biological Response to Brief Psychological Challenge
Acute Inflammatory Response to Psychological Stress
Primary: Cell-free Mitochondrial DNA — 165.79; 405.56; 175.45; 164.45 Copies per uL — p=0.86
N/A N=91 Cortisol Suppression and Startle Responses in Posttraumatic Stress Disorder (PTSD)
Post Traumatic Stress Disorder
Primary: Mean Baseline Startle Magnitude During Fear Conditioning — 48.401; 56.595; 115.778; 57.684 microvolts
Phase 4 N=40 Depression, Epinephrine, and Platelet Function
Major Depressive Disorder
Primary: Response of Participants, Defined by Change in the 21-item Hamilton Depression Rating Scale (HDRS) From Baseline to Week8 — 5; 9; 2; 4 participants — p=.918
N/A N=43 Neural Changes Associated With a Mindfulness-based Intervention for Young Adults With Childhood Maltreatment
Depression · Anxiety · PTSD
Primary: Changes in Subjects' Perceived Stress Level — -5.526; 1.000 score on a scale
Phase 4 N=66 Exploring the Effects of Corticosteroids on the Human Hippocampus
Hydrocortisone · Depression · Healthy Volunteers
Primary: Hippocampal Subfield Activation (Left Hemisphere) — -0.35; 0.03; -0.08; -0.07 Z-Score
Phase 2 N=63 Oxytocin Suppresses Substance Use Disorders Associated With Chronic Stress
Alcohol Use Disorder · Stress Disorders, Post-Traumatic · Anxiety Disorders
Primary: Change in Craving to Use Alcohol Rating (Visual Analog Scale) — 0.076; -0.928 score on a scale
N/A N=53 Stress in Inflammatory Bowel Disease
Inflammatory Bowel Diseases · Psychological
Primary: Retention Rate — 23; 25; 19; 22 Participants
N/A N=64 Effect of Omega-3 Supplementation During Pregnancy on Regulation of Stress
Healthy Pregnant Women
Primary: Maternal Cortisol Levels — 0.28; 0.34 ug/dL
Phase 2 N=16 INIA Stress and Chronic Alcohol Interactions: Glucocorticoid Antagonists in Heavy Drinkers
Alcohol Use Disorder
Primary: Change in Blood Oxygen Level Dependent (BOLD) fMRI Signal for Alcohol Versus Non-alcohol Stimuli — 0.267390; 0.040281; 0.058670; -0.069048 BOLD response
N/A N=58 Cranial Electrotherapy Stimulation and Acute Stress
Anxiety State
Primary: Change From Baseline in Heart Rate During Stressful Lethal Force Decision Making Task — 98.5; 111; 100.0; 114 bpm — p=.012
Phase 2 N=33 Effect of Oxytocin on Stress Response in Cocaine-dependent Individuals
Cocaine Dependence
Primary: Salivary Cortisol Levels — 0.18; 0.22 mg/dl
Phase 1 N=81 Remote Mindfulness Training Following Early Life Adversity
Stress · Mindfulness · Early Life Adversity
Primary: Feasibility of Recruitment (Screened Eligible) — 81; 56; 112; 642 Participants
Phase 1 N=73 Oxytocin Suppresses Substance Use Disorders Associated With Chronic Stress
Alcohol Use Disorders
Primary: Alcohol Craving — 2.89; 3.08 scores on a scale
Phase 2 N=51 Measures to Lower the Stress Response in Pediatric Cardiac Surgery
Tetralogy of Fallot (TOF) · Ventricular Septal Defects (VSD) · Atrioventricular Septal Defects (AVSD)
Primary: ACTH and Cytokine Levels — 116.9; 182.7; 135.3; 44.5 pg/mL
Phase 2 N=121 Stress Management for Patients With Multiple Sclerosis
Multiple Sclerosis
Primary: No.of Gd+ Lesions From Week 8 to Week 24 — 46; 33; 5; 13 participants — p=0.04