Phase 3 N=33 Comparison of Isovue 370 vs. Standard Protocol in Coronary Computed Tomographic Angiography (CTA)
Coronary Computed Tomographic Angiography
Primary: Contrast to Noise Ratio — 18.6; 20.5 CNR
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=89 Contrast-Enhanced Mammography for Breast Cancer Staging in Patients Referred for a Second Opinion
Breast Carcinoma · Invasive Breast Carcinoma
Primary: Accuracy of CEM for Incremental Cancer Detection in the Ipsilateral and Contralateral Breasts. — 41.4 % of malignancy in new CEM lesions
Phase 4 N=150 Thoracoabdominal Arortic CTA Study
Thoracic Aortic Aneurysm
Primary: Radiation Dose — 35.1; 25.4; 25.5 mSv
N/A N=513 Comparison of Contrast Agents During CT Angiography
Contrast Enhancement on Cardiac CT
Primary: Image Quality of the CT Scans Using Different Contrast Agents — 333; 357; 362; 288 hounsfield units
Phase 4 N=615 Screening Contrast-Enhanced Mammography as an Alternative to MRI
Breast Cancer
Primary: Cancer Detection Rate (CDR) Per 1,000 Screenings — 8.3; 18.3 CDR per 1,000 screenings
N/A N=132 Contrast Enhanced Spectral Mammography vs. MRI for Breast Cancer Screening
Breast Cancer
Primary: Area Under the Curve for Cancer Detection Rates of CESM Compared With Breast MRI for Breast Cancer Screening — 0.91; .91 Probability of malignancy
Phase 4 N=26 Accuracy of Contrast-Enhanced Ultrasound for Hepatocellular Carcinoma Post TACE
Hepatocellular Carcinoma
Primary: Residual Disease on CEUS Imaging. — 19 lesions
N/A N=109 PET Enhanced CT Scan Performance in Cancer
Cancer Disease Progression
Primary: Inter-observer (B1 and B2) Reproducibility of the PET-CT by Anatomical Regions — 0.7254; 0.7854; 0.7597; 0.6711 Weighted kappa concordance coefficient
N/A N=34 Computed Tomography Arteriograms (CTA) Volume Dose Reduction Study
Aortic Aneurysm · Contrast Induced Nephropathy · Aortic and Arterial Anomalies
Primary: Ascending Sinotubular Junction Measurement — 246.4; 287.5 Hounsfield units
Early Phase 1 N=8 The Role of Gadoxetate (Eovist) Enhanced CT in Evaluating Cholangiocarcinoma
Cholangiocarcinoma
Primary: Number of Subjects Where Hilar Cholangiocarcinomas Could be Visualized Using Gadoxetate Disodium Enhanced Dual Energy CT — 5 participants
N/A N=238 Study of Effectiveness of Smaller Gauge Fenestrated Catheters for Use in IV Contrast Enhanced CT Scans
Contrast Enhanced Computed Tomography
Primary: Acceptable Image Quality — 100; 100; 100 percentage of participants
Phase 2 N=63 Contrast-enhanced Ultrasound of the Kidney
Chronic Kidney Disease · Cystic Kidney Disease
Primary: Number of Lesions With a Change in Radiologist's Evaluation — 24 lesions
Phase 3 N=434 Ultravist: Safety and Efficacy in Computed Tomography of Head and Body
Computed Tomography · Diagnostic Imaging
Primary: The Quality of Visualization of the Contrast-Enhanced Computed Tomography (CECT) Images, Based on the Blinded Readers' Assessment. — 366; 17; 16; 3 Number of…
Phase 3 N=131 Contrast-enhanced Ultrasound Evaluation of Chemoembolization
Hepatocellular Carcinoma · Chemoembolization, Therapeutic
Primary: Percentage of Patients Correctly Identified as Requiring Tumor Re-treatment Two Weeks After Initial Chemoembolization — 94 percentage
N/A N=23 Computed Tomography Versus Standard 2D Mammography Versus 3D Tomosynthesis
Breast Cancer
Primary: Beta of CT Coronal View — 1.75 power-law slope(B)
Phase 4 N=300 Omnipaque Versus Gastroview as Oral Contrast for Abdominal and Pelvic CT
Healthy
Primary: Preferred Contrast Agent — 25; 29; 117; 116 participants — p=<0.001
Early Phase 1 N=25 Contrast-Enhanced Ultrasound Scan for the Estimation of Tissue Pressure in Patients With Breast Cancer
Breast Carcinoma
Primary: Correlation Between Subharmonic Aided Pressure Estimation (SHAPE) Results and Direct Measurements of Interstitial Fluid Pressure (IFP) — 0.2 Correlation coefficient…
Phase 2 N=50 Single Dose Safety, Tolerance and Pharmacokinetic Study in Healthy Volunteers Undergoing Contrast-enhanced Abdominal Computed Tomography (CT)
Healthy
Primary: Blood Urea Nitrogen and Creatinine Serum Values — 12.3; 14.7; 14.5; 12.8 mg/dL
N/A N=175 Focused Field of View Calcium Scoring Prior to Coronary CT Angiography
Radiation Safety · Coronary Computed Tomography Angiography · Coronary Artery Disease
Primary: Qualitative Quality Comparison — 4; 4 score on a scale
Phase 2 N=24 Contrast-Enhanced Ultrasound for Kidney Cancer Subtyping and Staging
Kidney Cancer
Primary: 3D CEUS Generated Metrics in Kidney Mass: Wash_In_Slope — 7.60 AU/second
N/A N=900 Uniformity of Oral Contrast Material in the Bowel
Known or Suspected Abdominal Disease
Primary: Number of Participants With Non-uniform Bowel Lumen Opacification at CT Imaging — 140; 73; 68 Participants
Phase 4 N=299 Iodixanol Versus Iopamidol in Patients Undergoing Contrast-Enhanced Computed Tomographic Imaging of Abdomen/Pelvis
Patient Comfort and Safety
Primary: Frequency of Subjects With Moderate/Severe Discomfort When Undergoing Contrast-Enhanced Computed Tomographic (CECT) Imaging of the Abdomen/Pelvis. — 53; 99 Number of…
N/A N=11 Contrast Enhanced Intraoperative Ultrasound for Detection and Characterization of Renal Mass Undergoing Open Partial Nephrectomy
Kidney Cancer
Primary: Successful Capture of IO-CEUS Images — 10 participants
Phase 2 N=37 The Role of Contrast Enhanced Ultrasound in Appendicitis
Acute Appendicitis
Primary: Number of Children With an Accurate Diagnosis of Appendicitis. — 6; 15; 1; 13 Participants
N/A N=128 Study of Dual-energy (DE) Contrast-enhanced (CE) Digital Mammography
Breast Cancer
Primary: Percent Accuracy of Contrast Mammography — 100; 67 percentage of accuracy
Phase 2 N=53 Two and Three Dimensional Contrast-enhanced Ultrasound for Screening of Renal Cell Carcinoma Recurrence Following Cryoablation
Renal Cell Carcinoma
Primary: The Sensitivity of Detecting RCC Recurrence (Using Contrast-enhanced MRI as a Reference Standard) on a Single Contrast-enhanced Ultrasound Exam. — 100 percent of patients
N/A N=24 Contrast ICE for Myocardial Scar in VT Ablations
Ventricular Tachycardia · Ischemic Cardiomyopathy
Primary: Number of Subjects With Myocardial Scar on Echo and Voltage Maps — 20 Participants
N/A N=139 Non-Contrast 4DCT to Detect Pulmonary Thromboembolic Events
Pulmonary Thromboembolisms · Pulmonary Embolism
Primary: Correlation of 4DCT Identified Perfusion With SPECT/CT Identified Perfusion — 0.45 Spearman correlation
N/A N=102 Left Atrial Imaging Prior to Cardioversion: Leveraging Computed Tomography to Rule Out Thrombus
Atrial Fibrillation
Primary: Time to Imaging — 28.1; 7.1 hours
Phase 4 N=139 Use of Electrical Impedence to Measure Lean Body Weight as a Determinant of the Dose of Contrast Media for Abdominal CT
IV Contrast Dosing
Primary: Difference in Enhancement of the Liver and Blood Vessels Over Time, Measured in Hounsfield Units (HU) — 116; 124; 121; 120 Hounsfield units (HU)