Clinical Trial Search

Primary: Average Change From Baseline in American Orthopedic Foot and Ankle Society(AOFAS) at 12 Months Post-surgery — 16.93 scores

Primary: Safety: Adverse Events — 0 participants

Primary: IKDC Score — 32.0; 25.5 score on a scale

Primary: Histomorphometry Safranin-O + Anti-Collagen II Antibody Staining — 1.01; 0.75 Ratio — p=0.003

Primary: Change From Baseline to Week 104 for the Participant's Knee Injury and Osteoarthritis Outcome Score (KOOS) Pain and Function (Sports and Recreational Activities) Scores…

Primary: Degree of Filling of the Lesion by Repair Tissue at 12 Months Through MRI. — 92.81; 85.22 Percentage of lesion fill — p=0.011

Primary: MRI Repair Tissue Comparison — 10; 2; 3; 4 Participants — p=0.61

Primary: MRI to Evaluate Success of Outcome. — 88.6 units on a scale

Primary: Change From Baseline in the International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Score at 1 Year — 23.3; 9.9 scores on a scale — p=<0.01

Primary: Number of Participants With Viable Specimens for Genetic Analysis — 14 participants

Primary: Knee Injury and Osteoarthritis Outcome Score (KOOS) (Clinical Outcome) — 12.0; 4.1; 19.1; 8.1 units on a scale — p=0.162

Primary: The Lysholm Knee Score — 82.2; 83.4 units on a scale

Primary: Degree of Lesion Filling (%Fill) by Repair Tissue at Degree of Lesion Filling (%Fill) by Repair Tissue at 5 Years Through MRI. — 93.79; 86.96 Percentage of lesion filled…

Primary: Change in Pain on the VIsual Analog Scale (VAS) — -.068 change in units on a scale from baseline

Primary: Visual Analogue Scale Pain Score — 2.3 units on a scale

Primary: Change From Baseline in Cartilage Volume in the Index Region of the Target Knee by MRI — 94.6; 9.3 µL — p=0.0575

Primary: WOMAC Functional Status - Difference From Baseline — 20.9; 18.5 Score — p=0.26

Primary: Score on Knee Injury and Osteoarthritis Outcome Score (KOOS) Survey — 67; 69; 67.7 score on a scale

Primary: Change in Numerical Pain Scale — -3.2 units on a scale

Primary: Change From MACI00206 Baseline for the Participant's Knee Injury and Osteoarthritis Outcome (KOOS) Pain and Function (Sports and Recreational Activities) Scores…

Primary: Knee Cartilage Volume — 2042; 1971 mm³

Primary: Composite Clinical Success — 68; 38; 16; 4 Participants — p=>0.01

Primary: Greater Cartilage Healing Measured by Glycosaminoglycan Content on dGEMRIC MRI

Primary: Knee Flexion Moment Impulse — 0.54; 0.50 Ratio — p=0.293

Primary: Change Form Baseline in WOMAC A Pain Subscale — -11.14; -11.82 cm — p=<0.025

Primary: Knee Pain During a Single Leg Squat — 5.6; 5.2; 4.1; 3.4 units on a scale

Primary: Evaluate for the Incidence of Patellar Crepitus Requiring Non-operative vs. Operative Treatment of Both the Study and Control Groups at a Minimum of 12 Months Following…

Primary: Change From Baseline in Cartilage Volume in the Index Region Measured by 7 Tesla MRI — 63.3; 49.8; 11.6 µL — p=0.2366

Primary: Changes in Serum COMP Accumulation, Triggered by Acute Exercise, After 12 Weeks of Different Regular Exercises — -1.60; -0.53; -0.19; -0.12 U/l

Primary: Infrapatellar Fat Pad Volume in MRI — 25154.96; 29202.39 mm^3