N/A N=80 Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis Stains
Caries Infiltration · Fluorosis · Dental Care
Primary: Esthetic Changes — 1.90; 5.50; 5.53; 5.35 score on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=38 Fluoride Varnish for Treatment of White Spot Lesions
White Spot Lesions
Primary: DIAGNOdent Readings at Baseline, Three and Six Months - Intergroup Comparison — 5.10; 6.01; 4.08; 5.50 units on a scale — p=0.636
Phase 3 N=315 Effect of pH and Fluoride Concentration of Dentifrices on Caries Control
Dental Fluorosis · Dental Caries
Primary: Evaluation of the Concentration of Fluoride Incorporated Into the Biofilm Done 6 Months After Initiation of Dentifrices Use. — 0.80; 1.32; 1.74 mmol/kg — p=<0.05
N/A N=3,345 Comparative Effectiveness of Treatments to Prevent Dental Caries
Dental Caries
Primary: Number of Participants With Arrested Dental Caries, Assessed Using a Clinical Oral Examination — 48; 53 Participants
Phase 1 N=20 Fluoride Retention in the Mouth of Older Adults
Hyposalivation
Primary: Fluoride Concentration in Dental Biofilm Fluid at Baseline — 0.24; 0.22 parts per million (ppm) of fluoride — p=0.8412
N/A N=29 Intra Oral Kinetics of Fluoride Containing Dentifrices
Tooth Erosion
Primary: Concentrations of Fluoride Ions in Saliva 60 Minutes Post Brushing Prior to Administration of the Orange Juice or De-ionised Water Rinse — 0.23; 0.23; 0.15 parts per…
N/A N=12 An Evaluation of Protective Effects of OpalSeal™ Against Early Dental Decay in Orthodontic Patients
Cavities of Teeth
Primary: Loss of Mineral Density in the Enamel — 70.8; 77.4 microns
Phase 3 N=65 In Situ Caries Model of Fluoride Toothpastes
Caries
Primary: Percent Surface Microhardness (SMH) Recovery of Enamel Specimens Exposed to NaF Toothpaste (1426ppmF) and AmF Toothpaste (1400ppmF) — 38.05; 41.06 Percentage SMHR…
N/A N=7,418 Comparative Effectiveness of School-based Caries Prevention
Dental Caries · Quality of Life
Primary: Proportion of Subjects With All Caries Arrested — 108; 101 Participants
N/A N=62 The Effect of Experimental Dentifrices on Remineralization of Caries Lesions In-situ
Oral Hygiene
Primary: Percentage Surface Microhardness Recovery (% SMHR) — 32.49; 31.81; 27.56; 22.62 Percentage of SMHR — p=<0.0001
Phase 2 N=20 Experimental Dentifrice Remineralization/Fluoride Uptake in an in Situ Model
Dental Erosion
Primary: Percentage Surface Micro-hardness Recovery (SMHR) of Enamel Specimens — 39.46; 38.31; 36.17; 17.26 % SMHR — p=0.7756
Phase 3 N=376 Fluoride Varnish Randomized Clinical Trial
Dental Caries
Primary: Number of Caries Incident Cases — 42; 23; 14 participants — p=<0.001
N/A N=46 Efficacy Evaluation of Two Different Fluoride Applications
White Spot Lesion
Primary: Measurement of White Spot Lesions by QLF Parameters: Delta F (Max) — -28.2; -26.3 percent change (%)
Phase 3 N=62 Effect of Fluoride in a Dentifrice on Remineralization of Erosive Lesions
Enamel Erosion
Primary: Percentage Surface Microhardness Recovery (%SMHR) Dose Response Relationship — 30.89; 28.71; 25.28; 21.03 %SMHR — p=<0.0001
Phase 4 N=15 Evaluation of the Fluoride Dose Response Using In Situ Caries Model
Caries
Primary: Enamel Fluoride Uptake (EFU) — 2.28; 4.51; 8.78; 14.05 μg F/cm^2
N/A N=15 Remineralization of Molar Incisor Hypomineralization (MIH) With a Hydroxyapatite Toothpaste
Molar Incisor Hypomineralization
Primary: Change in Mineral Density (MD) of Tooth — 26.02; 14.64; 29.26; 16.83 percentage of remineralization
Phase 3 N=60 In Situ Caries of Fluoride Toothpastes
Healthy Subjects · Partial Denture Wearers · Caries
Primary: Mean Percentage Surface Microhardness Recovery (%SMHR) of Enamel Specimens Exposed to NaF/Carbopol Toothpaste (1400 ppmF), NaF Toothpaste (1350ppmF) Compared to…
Phase 3 N=27 Evaluation of the Fluoride Dose Response of a Modified In Situ Caries Model
Caries
Primary: Percentage Surface Microhardness Recovery (%SMH) — 13.96; 30.59; 40.74; 48.28 Percent Surface Microhardness Recovery
N/A N=57 Silver Diamine Fluoride and Papain-Based Gel for Management of MIH-affected Molar in Paediatric Patients
Molar Incisor Hypomineralization · Dental Caries · Hypomineralization of Enamel
Primary: Clinical Outcome Based on Success After Intervention on MIH Affected Molar at 6 Months — 17; 18; 17 number of Successful MIH affected molars
Phase 4 N=65 Effect of Dentifrice Usage Regime on Delivery and Efficacy of Fluoride
Dental Caries
Primary: Percentage Surface Micro Hardness Recovery (% SMH), of Brushing for 2 Minutes Versus (vs.) Brushing for 45 Seconds With 1.5g of Experimental Dentifrice. — 41.61; 34.66 %…
N/A N=220 Study to Investigate the Stain Control of Two Stannous Fluoride Dentifrices
Extrinsic Dental Stain · Oral Hygiene
Primary: Overall Modified Lobene Stain Index (MLSI) Mean Score at Week 4 — 1.38; 1.43; 1.42; 1.38 Score on a scale — p=0.2681
N/A N=51 Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride
Dental Caries in Children · Dental Caries Class II · Dental Caries
Primary: Interproximal Caries Zone of Radiolucency — 9; 7; 10; 12 Number of teeth
N/A N=12 Dental Office Prevention Strategies for Children
Dental Plaque
Primary: Dental Plaque Levels Measures on Scale of 0-2 — 0.391 units on a scale
Phase 3 N=66 Stopping Cavities Study: Diammine Silver Fluoride
Dental Caries
Primary: Dental Caries Activity — .72; .05 Proportion of arrested caries lesions
Phase 3 N=57 In Situ Caries Efficacy of Fluoride Toothpastes
Caries
Primary: Percentage Surface Microhardness Recovery (%SMHR) of Sound Enamel Specimens Exposed to NaF Toothpaste (1450ppmF) and NaF Toothpaste (1400ppmF) — 28.31; 26.32 Percentage…
Phase 4 N=40 MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study
Dental White Spots · Dental Caries
Primary: Change in White Spot Lesions Count - Enamel Decalcification Index (EDI) — 40.2; 41.3 units on a scale
Phase 3 N=65 Evaluation of Plaque Fluid Fluoride Retention From Fluoride Toothpastes
Dental Caries
Primary: Natural Log Transformed Area Under the Fluoride Concentration in Plaque Fluid by Time Curve (AUC) Between 0-4 Hours — 0.54; 0.54 ln(μg*F*minutes/cm^2) — p=0.9762
N/A N=15 In Vivo Comparison of Salivary Fluoride Levels Following the Application of Different 5% NaF Varnishes
Dental Caries
Primary: Fluoride Concentration and Release — .09; .07; .09; .09 ppm
N/A N=30 In Vivo Investigation of Initial Stages of Enamel Erosion
Tooth Erosion
Primary: Change From Pre-acid Challenge (Baseline) Tooth Impression Grading Score Immediately Following an Acid Challenge — 3.75; 3.17 Scores on grading scale — p=0.2673
N/A N=41 Silver Diamine Fluoride Pilot Study (SDF)
Dental Caries
Primary: Assessment of Radiographic Change in Dental Cavity — 9; 11; 3; 2 Participants