Early Phase 1 N=60 Individual Differences in Drug Response
Differential Female Response to Δ9-tetrahydrocannabinol (THC)
Primary: Change From Baseline in Profile of Mood States (POMS) — 2.58; 4.28; 8.25; 0.7 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Early Phase 1 N=8 Progesterone for Cannabis Withdrawal
Cannabis Use Disorder · Cannabis Withdrawal
Primary: Change in Salivary Progesterone Level — 237.86; 97.87 pg/ml
Phase 4 N=14 Effects of Pregnancy-associated Hormones on THC Metabolism in Women
Pregnancy Related · Cannabis Use
Primary: Dronabinol Exposure — 7.0; 5.6; 5.1; 5.0 nM*h — p=>0.05
N/A N=28 Individual Differences in the Response to Drugs
Healthy
Primary: Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration — 4.79; 12.83; 11.08; 12.17 units on a scale
Phase 2 N=33 Gender Differences in Response to Nicotine Replacement Therapy and De-Nicotinized Cigarettes
Nicotine Dependence
Primary: Post- Cue Exposure Craving Nicotine Patch — 25.58; 25.6 score on a scale
Early Phase 1 N=43 Brain Imaging of Cannabinoid Receptors
Cannabis Use Disorder · Cannabis Dependence, Continuous
Primary: Distribution Volume (VT) — 1.27; 1.54; 1.14; 1.31 mL/cm^3 — p=0.02
Early Phase 1 N=24 Age-Related Effects of THC
Tolerance · Adolescent Behavior · THC
Primary: Change From Baseline in Profile of Mood States (POMS) — 5.75; 12.46; 18.55; 4.08 units on a scale
Phase 2 N=21 Pregnenolone and Marijuana Dependence
Marijuana Dependence
Primary: Subjective Rating of Marijuana Craving on 1-7 Likert Scale — 1.64; 0.80 units on a scale
Phase 2 N=34 Comparison of the Analgesic Effects of Dronabinol and Smoked Marijuana in Daily Marijuana Smokers
Pain Threshold · Mood
Primary: Pain Tolerance — 6.1; 2.8; 4.9; 1.5 seconds
N/A N=58 Mapping Brain Glutamate in Humans: Sex Differences in Cigarette Smokers
Sex · Cigarette Smoking
Primary: Glutamate in the Dorsal Anterior Cingulate Cortex — 8.11; 7.05 Institutional Units — p=0.027
Phase 2 N=25 Effects of Dronabinol (Oral THC) on Cannabis Use
Marijuana Smoking
Primary: Marijuana Self-administration - Progressive Ratio — 5.2; 4.5; 4.4 Progressive Ratios Completed
Phase 2 N=148 Impact of Progesterone on Stress Reactivity and Cannabis Use
Cannabis Use
Primary: Cannabis Craving — 3.7; 3.4; 4.3; 4.5 units on a scale
Early Phase 1 N=30 Behavior Brain Responses
Alcohol Drinking · Drinking Behavior · Physiological Effects of Drugs
Primary: Change in Subjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Subscales of the Drug Effects Questionnaire Across Sessions…
N/A N=10 4 mA tDCS, Estrogen, and Leg Muscle Fatigability
Healthy
Primary: Fatigue Index From the Isokinetic Fatigue Test — 61.7; 46.7; 57.28; 55.90 Percent decline — p=<0.05
Phase 2 N=24 The Effect of Prescription Medications in Marijuana Users
Marijuana Abuse
Primary: Peak Effect of Marijuana Withdrawal — 4.6; 4.1; 2.9; 1.7 units on a scale
Phase 1 N=12 Ph1 Marinol Interaction Study - Part 2 - 1
Marijuana Dependence
Primary: Number of Participants That Experience Cardiovascular Effects of Smoked Marijuana or Has Any Other Combination Side Effects. — 6; 6 participants
N/A N=190 Using Imaging to Assess Effects of THC on Brain Activity
Intoxication Alcohol · Intoxication THC · Intoxication Combined Alcohol THC
Primary: Change in Concentration of Oxygenated Hemoglobin Between Pre-drug and Post-drug Scans of Patients Completing the N-back Task. — 0.00000000042; -0.00000000126…
Phase 4 N=46 Effects of Delta-9 Tetrahydrocannabinol (THC) on Retention of Memory for Fear Extinction Learning in PTSD: R61 Study
PostTraumatic Stress Disorder
Primary: Brain Measures — 0.039567327; 0.092173636; 0.149446357; -0.021618 arbitrary units — p=< 0.05
Phase 1 N=33 Behavioral Pharmacology of THC and Alpha-pinene
THC · Alpha-pinene
Primary: Mean Peak Change From Baseline Drug Effect as Assessed by the Drug Effect Questionnaire (DEQ) — -1.2; 5.1; 67.2; 66.1 score on a scale
Phase 2 N=50 Laboratory Study of Cannabidiol on the Effects of Smoked Marijuana
Smoking, Marijuana
Primary: Mood Scale - Subscale 'Feeling High' — 4.35; 2.48; 0.39; 6.55 units on a scale VAS 1-100 mm
Phase 1 N=35 Behavioral Pharmacology of THC and D-limonene
D-limonene and THC Pharmacodynamics
Primary: Mean Peak Change From Baseline Anxiety as Assessed by the Drug Effect Questionnaire (DEQ) — -1.2; 13.8; 18.7; -1.9 score on a scale
Phase 4 N=70 Cannabinoids for Pain Control During Medical Abortion
Medical Abortion · Pain
Primary: Maximum Self-reported Pain Score on a Numeric Rating Scale — 7; 7 score on a scale
N/A N=28 Sex Differences in Risk for Alcohol Abuse
Alcohol Abuse
Primary: Brain Activation During Response Inhibition (BARI) - Alcohol Infusion — 1.83; 2.41 BOLD activation
N/A N=100 Estradiol Effects on Alcohol Across the Menstrual Cycle
Alcohol Use, Unspecified
Primary: Attentional Bias (Early Follicular Phase) — 347.99; 355.02 milliseconds
N/A N=124 Examining the Effect of the Nicotine Patch in Male and Female Smokers - 3
Drug Addiction · Smoking Cessation
Primary: Subjective Effects — 18.8; 23.1; 25.6; 24.2 units on a scale
Phase 2 N=95 Smoking, Sex Hormones, and Pregnancy
Nicotine Dependence · Contraception
Primary: Change in Smoking Urges — 5.0; 5.5 score on a scale
N/A N=38 Cannabidiol and Emotional Stimuli
Drug Addiction
Primary: Positivity Ratings of Social Images — 1.96; 1.68; 1.86; 1.93 score on a scale
N/A N=16 Effect of Oxytocin on Stress in Marijuana Users
Marijuana Dependence
Primary: Stress (as Measured by Cortisol) — 1.8; 2.1 nmol/L
N/A N=58 Hormones and Reduction in Co-users of Marijuana and Nicotine
Marijuana Dependence
Primary: Change in Marijuana Use as Defined by the TLFB — -1.7; -1.4; -0.9; -2.9 MJ use occasions per day
N/A N=49 Imaging Extrastriatal Dopamine Release in Tobacco Smokers and Nonsmokers
Nicotine Dependence
Primary: Percent Change in Binding Potential of Dopamine Release During PET Scan Post Amphetamine Administration — 14; 11.2; 1.9; 9.3 percentage change in binding potential