Clinical Trial Search

Primary: Percent of Participants Who Were Histologic Responders — 2.6; 38.8 percent of participants — p=<0.0001

Primary: Number of Participants With Histologic Response at the Final Treatment Period Evaluation (Week 16) — 1; 113; 104; 100 Participants — p=<0.001

Primary: Percentage of Subjects With ≤6 Peak Eosinophils/High-power Field (HPF) — 10; 19; 14; 16 Participants — p=0.001

Primary: Mean Change in Dysphagia Score — 15.4; 8.3 score on a scale — p=0.14

Primary: Change From Baseline in Pediatric EoE Symptom Score Version 2.0 (PEESS V2.0) at 12 Weeks — -14.3; -21.6 units on a scale — p=0.04

Primary: Change in Eosinophil Numbers Per High Power Field Proximally and Distally Between Baseline and Post-treatment and Between Both Groups — 0.6; -7.5 perecentage of eos per…

Primary: Histological Remission by Sponge Cytology — 13 Participants

Primary: Measurement of Eosinophilic Degranulating Protein Concentration — 456.5 ng/mL

Primary: Tissue Eosinophil Counts — 89; 11 # of eosinophils per high-power field

Primary: Change From Baseline in Peak Eosinophil Count — 63.3; 67.7; 58.9; -11.2 eosinophils per high power field

Primary: Absolute Change From Baseline in Straumann Dysphagia Instrument (SDI) Patient Reported Outcome (PRO) Total Score at Week 10 — -1.3; -3.0 Score on a Scale — p=0.0304

Primary: Change in Maximum Esophageal Eosinophil Count From Baseline to End of Double-blind Treatment. (Intent to Treat Population) — -10.8; -24.2 Eosinophils (Eos)/high power…

Primary: Number of Participants Who Responded — 7; 4 participants

Primary: Histological Response to Treatment — 11; 16; 7; 12 Participants — p=1.00

Primary: Esophageal Eosinophilia (Number of Eosinophils in the Esophagus) — 5.3 eosinophils/high power field

Primary: Change From Baseline in the Peak Esophageal Intraepithelial Eosinophil Count at Week 4 (Mean) — -9.2; -31.6; -7.8 eosinophil count per high power field

Primary: Change From Baseline in Mean Dysphagia Days (DD) at Week 24 — -6.85; -4.98 days — p=0.0005

Primary: Percentage of Participants Who Attained Remission. — 65.2; 0 percentage of participants

Primary: Number of Participants With Complete Response to Dysphagia — 9; 6 participants — p=0.74

Primary: Percent of Participants in Complete Histologic Remission — 100 percentage of participants

Primary: Percent Change From Baseline in Dysphagia Score in Patients With Eosinophilic Esophagitis (EE) — 69; 79 Percent Change

Primary: Post-Treatment Maximum Eosinophil Count (Aim 1) — 14.7; 20.9 eosinophils per high-power field — p=0.31

Primary: Proportion of Participants Who Had Relapse During the Entire Week 36 Period — 0.43; 0.24 proportion of participants — p=0.131

Primary: Percent Change From Baseline in Esophageal Peak Eosinophil Count (PEC) at Week 16 — -58.4; -39.4; -21.5 Percent change — p=0.0103

Primary: Percentage of Participants Achieving Peak Esophageal Intraepithelial Eosinophil Count of ≤6 Eosinophils Per High-power Field (Eos/Hpf) in All Three Regions at Week 24…

Primary: Part A: Percentage of Participants Achieving Peak Esophageal Intraepithelial Eosinophil Count of Less Than or Equal to (≤) 6 Eosinophils/High Power Field (Eos/Hpf) at…

Primary: Mean Percent Change From Baseline to End of Treatment in Peak Esophageal Eosinophil (EE) Levels — -37.60; -58.27; -56.46; 11.50 percentage change in eosinophils/hpf…

Primary: Peak Esophageal Eosinophil Count — 57.3; 71.3 Peak # of eosinophils counted per field

Primary: Percent of Participants in Histologic Remission at 16 Weeks — 17; 17 percentage of participants

Primary: Percent of Participants in Histologic Remission (<15 Eos/Hpf) — 34.3; 40.3 percentage of participants — p=0.58