Early Phase 1 N=26 Intranasal Oxytocin Administration and the Neural Correlates of Social and Non-Social Visual Perception
Social Perception
Primary: Amplitude Social — -3.72; -3.55; -3.28; -3.30 microvolts — p=.003
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 1 N=21 Brain Dynamics of Oxytocin
Brain Dynamics in Healthy Adults
Primary: Number of Benevolent Rounds — 6.8; 6.8 number of rounds
Phase 2 N=20 Deciphering the Role of Oxytocin in Motivation: an fMRI Study
Focus of Study: Neural Correlates of Oxytocin Administration
Primary: Functional Magnetic Resonance Imaging (fMRI) Data: Change in BOLD Activity Between Placebo and Oxytocin Treatment. — 0.7944; 0.5790; 0.6119; 0.6688 BOLD signal change…
Phase 4 N=40 Neural and Behavioral Effects of Oxytocin in Autism Spectrum Disorders
Autism Spectrum Disorders
Primary: Change From Baseline in Brain Activity During Task (Task-based fMRI) After a Single Dose of Nasal Spray — 0.11; -0.26; -0.15; -0.16 Change-from-baseline (BOLD response)
N/A N=51 Target Engagement for Oxytocin: Dose Ranging Study
Schizophrenia Spectrum
Primary: Mu Suppression on EEG — -0.0907; -0.0632; -0.0542; -0.1153 log10 transformed ratio (Hz)
Phase 2 N=30 The Effects of Oxytocin on Complex Social Cognition in Autism Spectrum Disorders
Autism · ASD
Primary: Empathic Accuracy Performance
N/A N=74 Intranasal Oxytocin and Maternal Neglect
Maternal Behavior
Primary: Differences in Brain Activation (Blood Oxygen Level Dependent [BOLD] Signal) of Dopamine Reward Regions and Prefrontal Cortex After Intranasal Oxytocin Administration in…
Phase 2 N=11 Oxytocin and Affect Processing in Posttraumatic Stress Disorder
Posttraumatic Stress Disorder (PTSD)
Primary: fMRI Analysis: Change in Anterior Insula Region — -12.6; -1.6; 10.6; -7.8 percentage of area activation
Phase 2 N=39 Oxytocin as Adjunctive Treatment of Schizophrenia
Schizophrenia
Primary: Eye Tracking: Fixation Count — 6.78; 9.19; 9.88; 7.94 Number of face fixations
Phase 2 N=28 Oxytocin and Social Cognition in Schizophrenia
Social Cognition · Social Anxiety · Emotional Intelligence
Primary: To Determine Whether Exogenous OT Enhances Emotional Intelligence and Improves Performance on Measures of Social Cognition for Schizophrenia or Schizoaffective Patients…
N/A N=449 Biological Basis of Individual Variation in Social Cooperation
Healthy
Primary: Healthy Volunteers-OT, Placebo: Mean Percent Signal Change in Right Caudate Nucleus in Men — 0.21; 0.07 percent signal change
N/A N=83 The Modulatory Effect of Oxytocin on Interoception
Interoception
Primary: Heartbeat Detection (Interoception) Accuracy — 0.637; 0.735 ratio of correct heartbeat counting
Phase 2 N=54 Effect of Oxytocin Nasal Sprays on Social Behavior in Social Anxiety Disorder
Social Anxiety Disorder
Primary: Social Cooperation — 4.42; 4.69 Ball tosses
N/A N=47 Effect of Intranasal Neuropeptide on Emotion Perception in Trait Anxiety
Social Intelligence
Primary: Affective Ratings in Affective Learning Task — -0.096; -0.12 units on a scale
Phase 3 N=10 Emotional Processing and Oxytocin Mechanisms in Premenstrual Dysphoric Disorder: A Pilot Study
Premenstrual Dysphoric Disorder
Primary: Change in Premenstrual Symptom Severity — 25.05; 27.36 units on a scale
Phase 4 N=32 Intranasal Oxytocin and Social Cognition, Implicit Preferences and Craving in Alcohol Drinkers
AOD Use, Abuse, and Dependence
Primary: Change in Craving on the Alcohol Urge Questionnaire (AUQ) After Administration of Oxytocin vs. Placebo During the 3-week Study. — 1.11; 0.69 units on a 7-pt Likert Scale
Phase 4 N=22 Effects of Intramuscular (IM) Oxytocin on Pupil Diameter and Heart Rate Variability (HRV)
Chronic Pain Due to Injury
Primary: Fluctuation in Pupil Diameter (Hippus) -Pre Drug Administration — 1.61; 1.71 milliseconds^2 — p=0.64
N/A N=82 An fMRI Study of Opioid-related Changes in Neural Activity
Social Acceptance
Primary: Bold Oxygen-level Dependent (BOLD) Activations in Prespecified ROIs — 0.117; 0.2545 BOLD signal — p=<.01
Phase 2 N=41 Oxytocin Administration in BDD and OCD
Body Dysmorphic Disorder · Obsessive-compulsive Disorder
Primary: Emotion Recognition Questionnaire — 18.67; 17.00; 17.00; 16.40 score on a scale
Phase 4 N=18 Effects of Oxytocin on Behavior and Physiology in a Psychotherapy Setting
Behavior · Anxiety
Primary: Verbal and Nonverbal Behavior in Therapy Session: Effects of Drug — 34; 34.8; 45.4; 46.0 Number of behaviors exhibited
Phase 2 N=51 Autism Oxytocin Brain Project
Autism · Autism Spectrum Disorder
Primary: Resting State Functional Connectivity (rsFC) Salience Network (Anterior Cingulate Cortex (ACC) and Insula Versus Visual Cortex) — 0.338; 0.400; 0.428; 0.522 z-scores…
Phase 4 N=83 Effects of Intranasal Oxytocin on Cigarette Smoking
Nicotine Dependence · Tobacco Smoking
Primary: Smoking Lapse Analogue Task (Delay Score) — 11.5; 10.9 minutes
N/A N=32 Neurobiological Bases of Paternal Nurturance
Healthy
Primary: Mean Percent Signal Change in Ventral Tegmental Area (VTA) — 0.54; 0.27 Percent signal change
Phase 2 N=40 Stimulant Oxytocin Study
Stimulant Use & Co-occuring Opioid Use Disorders
Primary: Number of Participants With Stimulant Positive Drug Screen — 9; 12; 9; 10 Participants
N/A N=24 Does Acute Oxytocin Administration Enhance Social Cognition in Individuals With Schizophrenia?
Schizophrenia
Primary: Social Cognition Composite Measure — 0.10; 0.23 Change in z-score
Phase 2 N=27 Effects of Oxytocin Nasal Spray on Social Affiliation
Schizophrenia
Primary: Social Affiliation Measured by Social Affiliative Role Play — 4.026; 4.111; 4.079; 4.194 units on a scale — p=0.758
N/A N=106 Oxytocin's Effect on Socioemotional Aging
Aging
Primary: Extent of Trust Behavior — 39.03; 44.42; 45.11; 46.06 monetary units
Phase 2 N=38 Sex/Gender Differences in Risk and Resilience to PTSD; Implication of Oxytocin
PTSD
Primary: Change in Amygdala Activation- Oxy Minus Placebo — -0.01; -0.02; 0.05; 0.21 percentage of BOLD signal change
Phase 2 N=290 Study of Oxytocin in Autism to Improve Reciprocal Social Behaviors
Autism Spectrum Disorders
Primary: Change in Aberrant Behavior Checklist-Modified Social Withdrawal Subscale ABC-mSW, a Measure of Social Reciprocity — 8.81; 8.68; 8.97; 8.68 score on a scale — p=0.503
Phase 2 N=33 Effect of Oxytocin on Stress Response in Cocaine-dependent Individuals
Cocaine Dependence
Primary: Salivary Cortisol Levels — 0.18; 0.22 mg/dl