N/A N=54 Depression Therapy to Improve Cardiovascular Risk in HIV
Depression · HIV
Primary: Change in Brachial Artery Flow-mediated Dilation From Baseline to Week 12 — -0.47; 0.29 absolute percent change — p=0.32
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=108 SSRI Effects on Depression and Immunity in HIV/AIDS
Depression · HIV · AIDS
Primary: Natural Killer Cell Activity, Measured in Lytic Units [Bryant J, Day R, Whiteside TL, and Herbeman RB: Calculation of Lytic Units for the Expression of Cell-mediated…
Phase 2 N=109 Neuroinflammation and Modulating Factors in Depression and HIV
Depression · HIV
Primary: Change in Patient Health Questionnaire (PHQ)-9 — 5; 7 units on a scale
N/A N=249 HIV Translating Initiatives for Depression Into Effective Solutions
HIV, Depression
Primary: Percentage of Participants With Depression Treatment Response — 33.3; 17.5 percent response — p=0.003
N/A N=89 Skills Based Counseling for Adherence and Depression in HIV+ Methadone Patients - 1
Adherence · Depression · Heroin Dependence
Primary: Percent Medication Adherence at 3-month Follow-up Assessment — 79.02; 73.66 percent (doses taken/doses prescribed) — p=<.05
N/A N=40 Depression and ART Adherence in HIV+ Latinos
Depressive Symptoms · HIV Infections
Primary: Depression From (1) Clinician-Administered MADRS Measure, and (2) Participant Self-Report Ratings With BDI-1a — 17.8; 19.2; 19.7; 17.7 Units on a scale
N/A N=187 Treating Chronic Pain and Depression in HIV+ Patients in Primary Care Settings
Pain Interference · Depression · Antiretroviral Adherence
Primary: Brief Pain Inventory Interference Scale at 3 Months — 5.03; 4.23 score on a scale — p=0.008
N/A N=304 Trial of Collaborative Depression Care Management for HIV Patients
Depression · HIV
Primary: Antiretroviral Medication Adherence — 89.2; 87.6 observed pills taken as % of expected
Phase 3 N=391 Maternal Depression Treatment in HIV
Depression
Primary: Rate of Maternal HIV Viral Suppression — 128; 132 Participants
N/A N=5,706 Computerized Substance Use and Depression Screening and Behavioral Treatment in HIV Primary Care
Substance Use Disorders · HIV · Depression
Primary: Change in Mental Health and Substance Use Screening Rates — 2008; 2379 Participants
N/A N=30 HIV-related Insomnia and Inflammation
Hiv · Insomnia
Primary: Change in hsCRP Levels at 24 Weeks — 2.19; 4.47 mg/L — p=0.607
N/A N=114 Effects of Mindfulness Training on Chronic Inflammation in HIV-Infected Adults
HIV
Primary: Interleukin 6 (IL-6) Biological Markers — 2.24; 2.63; 2.53; 2.88 pg/mL
Phase 2 N=177 Staying Well: A Clinical Trial of Mindfulness-Based Stress Reduction and Education Groups for HIV
HIV
Primary: Change in CD4 T-cell Count — -57.1; -70.3 cells/µl
N/A N=23 Support for Perinatal Adherence and Depression
Human Immunodeficiency Virus · Depression
Primary: Adherence to Antiretroviral Therapy Per Self-Report — 85.3; 79.0; 92.8; 77.8 percentage of self-reported adherence — p=0.11
Phase 4 N=80 A Pilot Trial of Perinatal Depression Treatment in HIV Infected Women
Perinatal Depression · HIV-1-infection
Primary: Number of Women Approached Who Agreed to Pre-Screening With EPDS — 240 Participants
N/A N=10 An Adaptive Intervention for Depression Among Latinos Living With HIV
Depression
Primary: Composite Measure of Feasibility for the Adaptive Treatment Strategy (ATS) — 5; 5; 4; 3 Participants
N/A N=156 IMPAACT 2002: Cognitive Behavioral Therapy and Medication Management for Treatment of Depression in US Youth With HIV
HIV · Depression
Primary: Depression Outcomes: Quick Inventory of Depression Symptomatology - Self Report (QIDS-SR) Score — 6.7; 10.6 units on a scale — p=0.01
Phase 1 N=46 PET Imaging of the Dopaminergic and Serotonergic Systems in Treated HIV Positive Subjects
Depression · HIV Infections · HIV-Associated Cognitive Motor Complex
Primary: Influx Constant (Ki) for 18F-FDOPA PET. — 0.01415; 0.01409; 0.01588; 0.01592 min-1
Phase 1 N=41 Bupropion For Reducing High-Risk Behaviors in Depressed Men Who Have Sex With Men (MSM)
HIV Infections · Depression
Primary: The Number of Sexual Partners in Unprotected Anal Intercourse Reported at 6 Months Minus the Number Reported at Enrollment. — -2.5; -4 Sexual partners — p=0.9
Phase 4 N=89 Treatment of Diabetes and Depression in Hispanics and African Americans and Its Effect on A1c and Quality of Life.
Diabetes · Depression
Primary: HbA1C (%) — 9.7; 10.0; 8.8; 8.0 Percentage of glycosylated hemoglobin
N/A N=309 Hepatitis C Translating Initiatives for Depression Into Effective Solutions
Hepatitis C · Depression
Primary: Number of Patients Who Initiated Hepatitis C Antiviral Treatment Within 12 Months of Enrollment — 11; 7 participants
Phase 4 N=14 Depression-Diabetes Mechanisms: Urban African Americans
Diabetes · Depression
Primary: Response of Participants, Defined by Change in the 21-item Hamilton Depression Rating Scale (HDRS) From Baseline to Week 24 — 2; 1; 2; 1 participants
N/A N=12 Psychosocial Intervention for Older HIV+ Adults With HAND
HIV/AIDS · Aging · Mild Cognitive Impairment
Primary: Feasibility - Session Attendance — 5; 5 Participants
N/A N=39 Depression Intervention Among Gay and Bisexual Men Receiving Treatment for Methamphetamine Use
HIV/AIDS · Methamphetamine Abuse · Depression
Primary: Depression Symptoms Over Time — -0.062 Units on a Scale
N/A N=216 Omega-3 Supplementation and Depression Clinical Trial
Depressive Symptoms
Primary: Change in BDI-II Depressive Symptom Scores — -13.9; -13.3 scores on BDI-II scale — p=0.21
N/A N=58 Texting to Improve Adherence in HIV+ With Bipolar Disorder
HIV Disease · Bipolar Disorder
Primary: Proportion Adherent to ARV and Psychotropic Medication by Electronic Monitoring System (MEMS) — 90.3; 90.0; 83.9; 90.0 percentage of taken doses — p=0.95
N/A N=125 Digital Star: HIV Prevention for Youth in Mental Health Treatment
Human Immunodeficiency Virus · Mental Health
Primary: HIV Knowledge — 11.10; 10.98 score on a scale
N/A N=250 Prevalence and Predictors of Neurocognitive Impairment Among HIV-infected Patients
HIV Infections · Memory
Primary: The Prevalence of Neurocognitive Deficits Among HIV-positive Patients as Defined by the Global Deficit Score Based on the Neuropsychological Testing Battery and to…
N/A N=116 Friendship Bench Mental Health Intervention for Adolescent Girls and Young Women in South African PrEP Delivery Settings
Depression · Pre-Exposure Prophylaxis
Primary: PrEP Adherence at Week 12 — 29; 22 Participants — p=0.44
N/A N=115 Healing Hearts and Mending Minds in Older Adults Living With HIV
HIV · Cardiovascular Disease · AIDS
Primary: Stroop Color and Word Test Score — 31.17; 28.89; 32.87; 30.69 number of correct responses