N/A N=22 Initial Effects of Kinesiotaping in Non Surgical Treatment of Hallux Valgus
Hallux Valgus · Pain
Primary: Adduction Angle of Hallux With X RAY — 22.6; 19.3 degrees
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 1 N=100 Bunionectomy Study (0000-063)
Acute Pain
Primary: Total Patient Controlled Analgesic (PCA) Hydromorphone Consumption Over the 24 Hours Post-surgery — 2.94; 2.07; 5.96 milligrams — p=0.005
N/A N=53 Timing of Weight Bearing After Hallux Valgus Surgery
Hallux Valgus and Bunion
Primary: Hallux Valgus Angle as a Measure of the Radiological Changes — 35.6; 37.4; 8.8; 7.2 degrees
N/A N=60 Metatarsal Phalangeal Joint Deformity Progression - R01
Diabetes Mellitus (DM)
Primary: Change in Metatarsal Phalangeal Joint Angle (Degrees) in People With Diabetes From Baseline and at a 3-year Period — 0.8; -0.1 degrees
Phase 3 N=193 Study of Postoperative Analgesia in Bunionectomy
Bunion · Hallux Valgus
Primary: Area Under the Curve (AUC) of the Numeric Rating Scale at Rest (NRS-R) Pain Intensity Scores — 124; 146 Units on a scale*hours
Phase 2 N=78 Phase 2 Bunionectomy HTX-011 Administration Study
Postoperative Pain
Primary: Mean Area Under the Curve (AUC) of the NRS-A (Windowed Worst Observation Carried Forward) Pain Intensity Scores — 278.36; 288.23; 126.93 pain intensity score*hr
Phase 2 N=430 Evaluation of the Efficacy and Safety of Locally Administered HTX-011 for Postoperative Analgesia Following Bunionectomy
Postoperative Pain · Bunions
Primary: Mean Summed Pain Intensity (SPI) Score Over 24 Hours — 69.16; 96.83; 83.38; 85.70 Units on a scale
Phase 2 N=87 A Phase 2 Study to Evaluate Pregabalin and Acetaminophen Compared to Acetaminophen and Placebo in Subjects Undergoing Bunionectomy
Postoperative Pain
Primary: Summed Pain Intensity (SPI) Between Group A and Group C — 153.08; 267.51 score on a scale — p=<0.001
Phase 2 N=59 Placebo-Controlled Evaluation of N1539 Following Bunionectomy Surgery
Pain, Post-operative
Primary: Number of Subjects With Adverse Events — 12; 10; 10 Participants
Phase 4 N=50 Continuous Wound Infiltration After Hallux Valgus Surgery
Hallux Valgus
Primary: Average Postoperative Numeric Rating Scale (NRS) for Pain — 2.0; 1.9 units on a scale — p=0.596
Phase 3 N=201 Evaluation of N1539 Following Bunionectomy Surgery
Pain, Post-operative
Primary: Summed Pain Intensity Difference Over the First 48 Hours (SPID48) — -6956.0; -4829.3 units on a scale — p=0.0034
Phase 3 N=428 Study of Diclofenac Capsules to Treat Pain Following Bunionectomy
Other Acute Postoperative Pain
Primary: The Time-Weighted Summed Pain Intensity Difference Measured Using the 100-mm Visual Analogue Scale From 0 to 48 Hours After Trial Entry (VASSPID-48), ANCOVA Model…
Phase 2 N=192 A Study of MDT-10013 in the Treatment of Acute Postoperative Pain Following Bunionectomy
Postoperative Pain
Primary: Summed Pain Intensity Over 1- 48hrs (SPI-48) From Cohort 1 to 3 — 252.29; 213.28; 191.97; 215.35 units on a scale
N/A N=11 Do Rocker Bottom Shoes and Ankle-Foot Orthoses Reduce Pain and Improve Mobility for Ankle Osteoarthritis Patients
Ankle Osteoarthritis · Healthy Ankles
Primary: Daily Step Count (# Steps) — 3453; 2399; 3453; 2745 steps
Phase 2 N=186 Dysport in Hallux Abducto Valgus (HAV) Phase IIa
Hallux Abducto Valgus
Primary: Least Square (LS) Mean Change From Baseline in the Daily Numeric Pain Rating Scale (NPRS) Score at Week 8 — -2.04; -1.71; -2.40 units on a scale — p=0.7669
Phase 3 N=412 Bunionectomy Study for Postoperative Analgesia (EPOCH 1)
Postoperative Pain
Primary: Mean Area Under the Curve (AUC) of the Numeric Rating Scale (NRS) Pain Intensity Scores With Activity (NRS-A) Through 72 Hours Postsurgery (AUC0-72), Compared With…
Phase 3 N=200 Multicenter Study to Evaluate the Analgesic Efficacy of XP21L in Subjects With Pain Following Bunionectomy Surgery
Pain, Postoperative
Primary: Average Numeric Pain Rating Score (NPRS) Over 48 Hours After Bunionectomy — 3.3; 5.7 units on a scale
Phase 2 N=100 Acute Pain Study Following Bunionectomy
Pain
Primary: Sum of Pain Intensity Difference (SPID) Using the Pain Intensity Visual Analog Scale (VAS) — 259.0; 39.4 scores on a scale
Phase 3 N=201 Multicenter Study to Evaluate the Analgesic Efficacy of XP21L in Subjects With Pain Following Bunionectomy Surgery
Pain, Postoperative
Primary: Average Numeric Pain Rating Score (NPRS) Over 48 Hours After Bunionectomy — 2.5; 5.6 units on a scale
Phase 2 N=250 Hydrocodone/Acetaminophen for Acute Pain Following Bunionectomy
Pain
Primary: Sum of Pain Intensity Difference (SPID) Using the Pain Intensity Visual Analogue Scale (VAS) — 720.5; 239.9; 614.4; 450.8 scores on a scale
N/A N=79 Gait Modification Treatment for Knee Osteoarthritis
Knee Osteoarthritis
Primary: Change From Baseline to Week 17 and From Baseline to Week 21 in Pain as Measured by Numerical Rating Scale — -2.1; -1.8; -2.2; -1.5 units on a scale — p=0.495
Phase 2 N=147 Study of CA-008 (Vocacapsaicin) in Bunionectomy Patients
Post-surgical Pain
Primary: Change in Postsurgical Pain Based on the Weighted Sum of Pain Intensity (SPI) Assessments Over 96 Hours of the NRS Scores = Area Under the Curve (AUC) — 317.09; 321.72…
Phase 4 N=100 The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus Surgery
Postoperative Pain
Primary: Number of Patients Requiring Rescue Medication — 29; 36 patients
Phase 3 N=24 Allograft Transplantation in the Treatment of Osteoarthritis of the Metatarsophalangeal (MTP) Joint of the Great Toe
Osteoarthritis
Primary: Allograft Stability — 0
Phase 3 N=409 Tramadol Versus Placebo in the Management of Postoperative Pain Following Bunionectomy
Pain Management
Primary: The Sum of Pain Intensity Differences (SPID) Through 48 Hours Post First Dose — -122.8; -110.9; -97.8 score on a scale — p=<.005
N/A N=38 Wedged Orthoses and Knee Osteoarthritis
Knee Osteoarthritis
Primary: Knee Adduction Moment at Baseline — 0.376; 0.342 Nm/(kg-m)
Phase 3 N=291 A Trial to Evaluate CG5503 Efficacy and Safety in Acute Pain After Bunionectomy
Bunionectomy · Pain · Postoperative Pain
Primary: Sum of Pain Intensity Differences Relative to the Baseline Pain Intensity. — 46.2; 102.5; -17.5 units — p=<0.0001
N/A N=64 Mid-term Outcomes of First MTP Arthroplasty With Primus™ FGT Implant.
Hallux Limitus of Left Great Toe · Rheumatoid Arthritis · Arthritis of 1st Metatarsophalangeal Joint
Primary: AOFAS Hallux-MTP-IP Score - Overall — 88.9 units on a scale
Phase 3 N=462 Study of Indomethacin Capsules to Treat Pain Following Bunionectomy
Other Acute Postoperative Pain
Primary: The Time-Weighted Summed Pain Intensity Difference Measured Using the 100-mm Visual Analogue Scale From 0 to 48 Hours After Trial Entry (VASSPID-48) — 508.2; 329.8…
Phase 3 N=373 Study of Indomethacin Capsules to Treat Pain Following Bunionectomy
Other Acute Postoperative Pain
Primary: The Time-Weighted Summed Pain Intensity Difference Measured Using the 100-mm Visual Analogue Scale From 0 to 48 Hours After Trial Entry (VASSPID-48) — 598.670; 623.162…