N/A N=23 Intracranial Pressure in Experimental Models of Headache
High Altitude Headache
Primary: Change in Optic Nerve Sheath Diameter by Ultrasonography — 0.02; 0.02 mm — p=0.98
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=41 Rapid Acclimatization to Hypoxia at Altitude
Physiological Function in Low Oxygen Environment
Primary: Magnitude of Decrement in Exercise Time Trial Performance in Hypoxia (Low Oxygen) Compared With Normoxia (Normal Oxygen). — 22.3; 25.2; 22.2; 24.0 minutes
Phase 4 N=99 Three New Ideas to Protect Special Forces From the Stress of High Altitude
Mountain Sickness
Primary: Change in Environmental Symptoms Questionnaire at High Altitude — 0.132; 0.122; 0.080; 0.069 score on a scale
N/A N=91 Oxygen Therapy for the Treatment of Undifferentiated Headache in the Emergency Department
Headache
Primary: Time to Relief (Min) — 92.2; 83.9; 35.4 Minutes
Phase 3 N=89 Prevention of Altitude Illness With Non-steroidal Anti-inflammatory Study (PAINS)
Altitude Sickness
Primary: Acute Mountain Sickness — 19; 26 Participants
Phase 3 N=103 Altitude Sickness Prevention and Efficacy of Comparative Treatments
Acute Mountain Sickness
Primary: Number of Participants With Acute Mountain Sickness — 24; 22; 15 Count of participants
Phase 4 N=130 Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing
Prophylaxis of Acute Mountain Sickness
Primary: Number of Participants With Acute Mountain Sickness as Measured by the Lake Louise Score — 21; 21 Participants
Phase 4 N=22 Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude
Hypertension, Pulmonary · Altitude Sickness
Primary: Mean Pulmonary Artery Pressure — 16.8667; 15.6545; 16.3800; 16.6833 mm Hg
N/A N=219 Study Looking at End Expiratory Pressure for Altitude Illness Decrease (SLEEP-AID)
Acute Mountain Sickness
Primary: Incidence of Acute Mountain Sickness — 18; 16 Participants
Phase 2 N=44 Normobaric Oxygen (NBO) Therapy in Acute Migraine
Migraine
Primary: Change in Pain Scores From 0-30 Minutes on a Visual Analog Scale (VAS) — 1.38; 1.22 units on a scale — p=0.674
Phase 3 N=28 Drug Combination on Exercise Performance at High Altitude
Acute Mountain Sickness
Primary: Time (Minutes) to Complete 2 Miles on a Treadmill — 1544; 1540 seconds
Phase 2 N=31 Pilot Study of VVD-101 for the Treatment of Delayed Alcohol-Induced Headaches
Delayed Alcohol Induced Headache
Primary: Headache Severity 2 Hours Post Treatment — 2.18; 2.09; 0.85; 1.17 units on a scale
Phase 2 N=12 Evaluation of the Attenuation by Aes-103 of Hypoxia Mediated Decrements in Endurance Exercise Performance
Hypoxia
Primary: Primary Objective Endurance Exercise Performance — 22.4; 24.5; 24.0; 24.6 minutes
N/A N=20 The Psychophysiological Effect of Simulated and Terrestrial Altitude
Hypoxia · Altitude Hypoxia · Altitude Sickness
Primary: Oxygenation of the Brain — 54.6; 54.3; 59.4; 55.4 percentage of oxygen saturation
Phase 4 N=27 Effects of Nebivolol Versus Carvedilol on Cardiopulmonary Function at High Altitude in Healthy Subjects.
Hypoxia · Altitude · Heart Failure
Primary: Peak Exercise Oxygen Consumption — 33.9; 37.6; 38.0; 33.9 ml/Kg/min — p=0.01
N/A N=309 Prospective ED Headache Cohort Study
Headache
Primary: Number of Participants Who Report Moderate or Severe Pain Within 24 Hours of Emergency Department(ED) Discharge — 53; 6; 20 Participants
Phase 4 N=166 INTERVENCION Trial
Blood Pressure, High
Primary: Change is 24-hour Systolic Blood Pressure From Baseline to 4 Weeks — -5.9; -7.5; -8.4 mmHg
Phase 4 N=162 Dexamethasone for Post Traumatic Headache
Post-Traumatic Headache
Primary: Frequency of Moderate or Severe Headache After Emergency Department (ED) Discharge — 31; 29; 42; 44 Participants — p=0.751
N/A N=30 Comparison of Oxygen Delivery Devices for Reversal of Altitude-Induced Hypoxemia in Normal Subjects
Hypoxemia · Hypobaric Hypoxemia
Primary: Return of Oxygen Saturation to Baseline (Sea Level) Values — 6; 8; 10; 4 participants — p=0.3
Phase 4 N=62 Acute Headache Treatment in Pregnancy: Occipital Nerve Block vs PO Acetaminophen With Caffeine
Headache · Pregnancy Related · Occipital Nerve Block
Primary: Number of Participants With Response to Occipital Nerve Block in Pregnancy — 20; 16 Participants — p=0.30
Phase 2 N=21 Metoclopramide for Post-Traumatic Headache. A Pilot Study
Post-Traumatic Headache
Primary: Number of Participants With Sustained Headache Relief — 12 Participants
Phase 4 N=50 Comparative Study Between Hydrocortisone and Mannitol in Treatment of Postdural Puncture Headache
Headache
Primary: Number of Patients (in Digits) Got Earlier Relief of PDPH (in Hours) After Use of Hydrocortisone or Mannitol. — 25; 25 Participants
N/A N=494 Postoperative Headache in Elective Surgery Patients
Drug Withdrawal Headache
Primary: Frequency of Postoperative Headache in Elective Surgery Patients — 126; 37; 89 participants
N/A N=10 High Altitude and Exogenous Carbohydrate Oxidation
Glucose Metabolism · High Altitude
Primary: Rate of Exogenous Carbohydrate Oxidation — 0.44; 0.35 g/min
Phase 4 N=5 An Efficacy and Safety of Proprietary Formulations of Oral Ketamine + Aspirin in Treatment of Acute Headache
Pain
Primary: Change in Pain Score at 60 Minutes — 4; 5 score on a scale
Phase 3 N=160 Metoclopramide for Post Traumatic Headache
Post-Traumatic Headache
Primary: 0-10 Pain Scale on Which 0 = no Pain and 10= the Worst Pain Imaginable — 5.2; 3.8 units on a scale
Phase 3 N=205 Headache in the Emergency Department (ED) - A Multi-Center Research Network to Optimize the ED Treatment of Migraines
Migraine
Primary: Persistent Headache Pain Free at 24 Hours — 26; 19 Participants
Phase 4 N=16 Gabapentin for Headache in Aneurysmal Subarachnoid Hemorrhage
Aneurysmal Subarachnoid Hemorrhage
Primary: Average Numeric Pain Score — 5.2; 5.8 score on a scale — p=0.7
Phase 2 N=50 Amitriptyline to Prevent Headache After Traumatic Brain Injury
Brain Injuries · Post-Traumatic Headache
Primary: Frequency of Headaches — 10 Participants — p=.101
Phase 3 N=226 Ibuprofen Sodium Tension Headache Study
Pain
Primary: Time-weighted Sum of Pain Relief Rating and Pain Intensity Difference From 0-3 Hours (SPRID 0-3) for Ibuprofen Sodium Versus Placebo Tablet — 9.6; 3.5 units on scale…