Phase 4 N=82 Spinal Anesthesia Induced Hypotension During Cesarean Section
Hypotension
Primary: Incidence of Maternal Hypotension — 10.8; 27 percentage of participants
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Phase 4 N=80 Variable Rate Phenylephrine Infusion for Prevention of Spinal-induced Hypotension for Cesarean Delivery
Anesthetic Complication Spinal
Primary: Number of Physician Interventions Needed to Maintain Maternal Blood Pressure After Spinal Anesthesia Within 20% of Baseline and to Treat Bradycardia During Cesarean…
N/A N=110 Phenylephrine in Spinal Anesthesia in Preeclamptic Patients
Preeclampsia · Hypotension
Primary: The Umbilical Artery pH — 7.22; 7.20 pH — p=.38
Phase 4 N=81 Phenylephrine vs. Norepinephrine Infusion After Spinal Anesthesia for Cesarean Delivery
Effects of; Anesthesia, in Labor and Delivery
Primary: Number of Rescue Boluses to Maintain SBP — 25; 21 rescue boluses — p=0.12
Phase 4 N=178 Preventing Hypotension in Parturients With an Elevated Body Mass Index (BMI)
Hypotension
Primary: Incidence of Nausea and Vomiting — 59; 37 participants
N/A N=60 Ninvasive Cardiac Output Measurements During Cesarean Delivery Under Spinal Anesthesia.
Hypotension During Cesarean Delivery · Spinal Anesthesia
Primary: Percentage of Participants With a Cardiac Output Within and Outside 20% of Baseline Values — 71; 66; 29; 34 percentage of patients — p=0.37
N/A N=446 Thoraco Lumbar Vertebral Length and Bupivacaine Dosage in C-Section
Obstetric Anesthesia Problems · Bupivacaine Adverse Reaction
Primary: Hypotension Rate Among the Groups — 9; 26; 37 Participants
N/A N=109 Pre-epidural Sequential Compression Devices (SCDs) to Prevent Hypotension During Labor
Hypotension · Labor Complication
Primary: Hypotension — 4; 4 participants
Phase 3 N=120 Calcium Chloride for Prevention of Blood Loss During Intrapartum Cesarean Delivery
Uterine Atony · Uterine Atony With Hemorrhage · Postpartum Hemorrhage
Primary: Quantitative Blood Loss — 840; 1051 milliliters — p=<0.05
Phase 4 N=60 Oxytocin And Uterotonic Agent Use For Cesarean Delivery
Uterine Atony · Hypotension
Primary: 1. Amount of Oxytocin to Obtain Satisfactory Uterine Tone. — 8.4; 4.0 IU
Phase 4 N=32 Angiotensin II in General Anesthesia
Hypertension
Primary: Median Dose Required to Increase the Systolic Blood Pressure (SBP) — 35; 43; 45 ng/kg/min
N/A N=200 Uterine Cooling During Cesarean Delivery to Reduce Blood Loss and Incidence of Postpartum Hemorrhage
Postpartum Hemorrhage · Uterine Atony
Primary: Blood Loss — 616; 418; 141; 106 cc
N/A N=34 Hypotension Prediction Index to Predict Epidural-labor Analgesia Induced Hypotension
Anesthesia, Epidural · Hypotension
Primary: Time-to-treatment of Hypotension (Minutes) — 21.8; 23.1 minutes
Phase 3 N=51 Oxytocin Infusions and Blood Loss in Patients Undergoing Elective Cesarean Delivery.
Postpartum Hemorrhage
Primary: Total Estimated Blood Loss — 512; 634 ml
Phase 3 N=40 Hyperbaric Bupivacaine Versus Hyperbaric Prilocaine 2% for Cesarean Section Under Spinal Anesthesia
Pregnant Women · Pain · Hypotension
Primary: Time to Regression of Motor Block — 180; 130 minutes
Phase 4 N=160 Multimodal Uterotonics at the Time of Cesarean Section in Laboring Patients
Uterine Atony With Hemorrhage
Primary: Number of Participants With Need for Additional Uterotonics (Methylergonovine, Carboprost, Misoprostol) — 80; 80 Participants
N/A N=102 Leg Elevation to Prevent Hypotension During Labor
Hypotension · Labor Complication
Primary: Number of Patients With Maternal Hypotension Requiring Treatment — 6; 11; 48; 27 Participants
Phase 2 N=66 The Prevention of Hypotension After Epidural Analgesia After Major Surgery
Hypotension · Pain
Primary: Changes Between the 3 Groups Assessed by Blood Pressure Measurement — 5; 2; 3; 10 Participants — p=0.165
Phase 2 N=100 The Effect of Tranexamic Acid on Postpartum Hemorrhage During and After Cesarean Delivery
Hemorrhage
Primary: The Amount of Hemorrhage During Cesarean Delivery and Within 2 Hours Afterward — 260; 380 ml
N/A N=306 Prevention of Intraoperative Nausea and Vomiting During Cesarean Section
Cesarean Delivery
Primary: Intraoperative Nausea and Vomiting — 23; 31; 49 participants
Phase 4 N=120 Intravenous Dexmedetomidine for Cesarean Section
Breast Feeding · Analgesia Obstetrical · Postoperative Pain
Primary: Postoperative Pain Score (Visual Analogue Scale, VAS) at Rest — 3.143; 2.897; 1.665; 1.25 units on a scale — p=<0.05
Phase 2 N=40 Calcium Chloride for Prevention of Uterine Atony During Cesarean
Uterine Atony · Uterine Atony With Hemorrhage · Cesarean Section Complications
Primary: Uterine Atony — 4; 10 Participants
Phase 2 N=52 The Effect of Ondansetron on Cardiac Output in Elective Cesarean Deliveries
Cardiac Output
Primary: Change in Cardiac Output From Baseline to 20 Minutes Post-spinal — -2.05; -1.92 L/min
Early Phase 1 N=70 Comparison of Chloroprocaine vs Lidocaine for Epidural Anesthesia in Cesarean Delivery
Surgical Anesthesia, Cesarean Section
Primary: The Onset Time to Surgical Anesthesia — 558; 655 seconds — p=0.10
N/A N=40 Pre-warming Prevents Hypothermia in Elective Cesarean Section
Hypothermia
Primary: Maternal Hypothermia — 36.6; 36.4; 36.5; 36.3 Centigrades — p=<0.05
N/A N=276 Pulse Pressure and Post-epidural Fetal Heart Rate Changes
Fetus or Neonate Affected by Maternal Epidural Anesthesia During Labor and Delivery
Primary: Incidence of New-onset Category II or III Fetal Heart Rate Tracings — 72; 52 Participants
Phase 4 N=123 Buccal Misoprostol During Cesarean Section for Preventing Postpartum Hemorrhage
Postpartum Hemorrhage
Primary: Need for Additional Uterotonic Medications — 10; 40 percentage of participants — p=<0.01
Phase 4 N=602 Prophylactic Ephedrine and Combined Spinal Epidurals for Labor
Labor Pain
Primary: Early Profound Fetal Bradycardia — 8; 14 participants — p=0.18
N/A N=65 Does Heart Rate Variablity (HRV) Predict Hypotension in Patients Undergoing Cervical Myelopathy Surgery ?
Heart Rate Variability
Primary: Heart Rate Variability (HRV) — 1439; 2191 ms2
N/A N=17,463 Decision Support for Intraoperative Low Blood Pressure
Hypotension
Primary: Postoperative Acute Kidney Injury — 1333; 372; 9670; 2785 Participants