Early Phase 1 N=35 taVNS Paired With Bottle Feeding in Infants Failing Oral Feeds
Poor Feeding · Infant Development · Vagus Nerve Stimulation
Primary: Number of Infants Who Took All Feeds by Mouth (Responders) — 8; 11 Participants
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=16 BabyStrong Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) Paired Bottle Feeding to Improve Oral Feeding
Infant Feeding Problems, taVNS
Primary: Bradycardia — 0; 0; 0; 0 Participants
Early Phase 1 N=10 NAC +taVNS in IDM Who Are Poor Oral Feeders
Infant of Diabetic Mother · Oxidative Stress · Vagus Nerve Stimulation
Primary: Daily Oral Feeding Volumes : Difference in Mean Increase — 2.1 ml/kg/day po daily change — p=0.009
Early Phase 1 N=4 Extending taVNS Paired With Infant CIMT Into a Home-Based Setting
Cerebral Palsy
Primary: Device Feasibility — 33.33 percent time EMG taVNS stimulation
Early Phase 1 N=6 CIMT and taVNS for Hemiplegia in Infants
Infant Development · Hemiplegia · Constraint Induced Movement Therapy
Primary: CIMT Fidelity — 3.76 score on a scale
N/A N=121 Somatosensory Modulation of Salivary Gene Expression and Oral Feeding in Preterm Infants
Infant, Extremely Low Birth Weight · Feeding Behavior
Primary: Salivary Gene Expression — 21.344; 21.420; 20.931; 21.100 Delta-CT — p=<0.01
N/A N=15 Post-stroke Pain taVNS
Stroke · Pain
Primary: Thermal Pain Threshold — 41.84; 42.51 Celsius
N/A N=31 Transcutaneous Vagus Nerve Stimulation (taVNS) Dosage Study 1
Healthy
Primary: Tolerability Measured by Tolerability Questionnaire — 2.2; 2.2 score on a scale
N/A N=7 Effect of Nasal Continuous Positive Airway Pressure on The Pharyngeal Swallow in Neonates
Deglutition Disorders · Respiratory Distress Syndrome In Premature Infants · Respiratory Aspiration
Primary: Pharyngeal Phase Dysphagia — 7; 7 Participants
N/A N=49 Non-invasive Vagal Nerve Stimulation (nVNS) for Symptomatic Exacerbation of Nausea in Patients With Gastroparesis and Related Disorders
Chronic Unexplained Nausea and Vomiting · Gastroparesis
Primary: Average Daily Use of Rescue Medications for Exacerbation of Nausea/Vomiting. — 1.186; 0.551; 0.754; 0.447 medications/day
N/A N=8 tAN to Mitigate Withdrawal Behaviors in Neonates
Neonatal Abstinence Syndrome
Primary: Number of Subjects With no Adverse Events Related to Bradycardia (HR < 80 Bpm), Worsening of Swallowing or Feeding, Skin Irritation, or Elevation of Neonatal Infant Pain…
N/A N=22 A Study of Neurophysiologically Based Occupational Therapy Intervention (NBOTI) for Feeding in the NCCU.
Cerebral Palsy · Sensorimotor Deficits · Sensory Processing Disorder
Primary: A Priori H1. The Number of Days to Achieve Oral Feeding Between the Intervention Group and the Matched Historical Comparison Group - From All Tube to All Oral Feeding…
N/A N=40 Nasal Noninvasive NAVA in the Very Low Birth Weight Infant
Inadequate; Pulmonary Ventilation, Newborn · Infant, Very Low Birth Weight
Primary: Change in Partial Pressure of Carbon Dioxide on Capillary Blood Gas — 0.019 mm Hg
N/A N=115 Efficacy of Ear Neurostimulation for Adolescents With Functional Abdominal Pain
Functional Disorder of Intestine · Nausea Persistent
Primary: Pain Frequency-Severity-Duration Scale (PFSD) Score — 5.0; 7.0 units on a scale — p=0.003
N/A N=19 Non-invasive Intervention for Apnea of Prematurity
Apnea of Prematurity · Hypoxia · Bradycardia
Primary: Change in Total Number of Episodes of Apnea/Breathing Pauses During Intervention and Without Intervention — 284.13; 174.27 breathing pauses
Early Phase 1 N=20 taVNS for Upper Limb Rehabilitation
Stroke
Primary: Change in Fugl-Meyer Assessment of the Upper Extremity — 5; 3.14 score on a scale
N/A N=22 Cold Milk for Dysphagia in Preterm Infants
Dysphagia of Newborn
Primary: Percentage of Infants With Improvement of Dysphagia — 58 Percentage of patients
N/A N=30 How Does the Type of Waveform Affect Tolerability With Transcutaneous Auricular Vagus Nerve Stimulation?
Healthy
Primary: Tolerability Measured by Tolerability Questionnaire — 2; 2 score on a scale
N/A N=100 A Clinical Trial of A Pacifier-Activated Music Player
Prematurity
Primary: Suck Rate and Efficiency: Change From Pre-test (Day 0) to Post-test (Day 5) — 2.0; 0.9 mL/min
N/A N=56 Evaluation of an Interdisciplinary Decision Guide for Infant Feeding Assessment
Premature Birth · Feeding and Eating Disorders of Childhood
Primary: Number of Participants That Recommend Feeding Therapy — 27; 27; 1; 1 Participants
N/A N=33 taVNS in Mild to Moderate Parkinson's Disease
Parkinson Disease
Primary: Change in Motor Function Score as Assessed by Modified Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III — 0.72; 0.01 score on a…
N/A N=101 Effects of Prefeeding Oral Stimulation on Feeding Performance in Preterm Infants
Preterm Infant · Oral Feeding Performance
Primary: Length of Transition Period — 16.0; 16.9 days — p=0.63
N/A N=24 taVNS Cold Pressor
taVNS · Brain Stimulation
Primary: Mean Heart Rate (Before CPT/taVNS) — 72.86; 72.0 beats per minute
N/A N=21 Acupuncture in Neonatal Abstinence Syndrome (NAS) Babies
Neonatal Abstinence Syndrome
Primary: Number of Participants With Skin Breakdown and / or Cellulitis — 0 participants
N/A N=189 Direct Swallowing Training and Oral Sensorimotor Stimulation in Preterm Infants
Premature Birth of Newborn · Intervention Studies
Primary: Days From Start to Independent Oral Feeding — 21.1; 17.2; 14.8 days
N/A N=130 Maternal Role in Oral Feed Establishment in Preterm Neonates
Preterm Birth · Tube Feeding · Swallowing Disorder
Primary: Transition Time to Full Oral Feeding — 10; 9 days
Phase 1 N=19 Non-invasive Vagal Nerve Stimulation in Alcohol Use Disorder
Alcohol Use Disorder
Primary: Treatment Acceptability Questionnaire (TAQ) — 5.7; 6.4 score on a scale
N/A N=24 Noninvasive Vagus Nerve Stimulation (VNS) for Neuromotor Adaptations
Healthy Young Adults
Primary: Visuomotor Skill — 1; 1; 0.870; 0.969 Ratio of the baseline value — p=0.0096
N/A N=76 Neonatal Gastro-Esophageal Reflux Disease (GERD) Management Trial
Gastroesophageal Reflux Disease
Primary: CLINICAL OUTCOME OF FEEDING SUCCESS — 33; 44 percentage of participants — p=0.28
N/A N=134 Effect of a Vibratory Stimulus on Mitigating Nociception-specific Responses to Skin Puncture in Neonates
Infant, Newborn · Infant, Premature · Pain Perception
Primary: Change in Nociception-specific Brain Activity — 17.9; 9.9; 11.5; 10.2 microvolts*milliseconds — p=<0.001