21 closest matches · ranked by relevance
Intermittent Explosive Disorder
Primary: Overt Aggression Scale-Modified for Outpatient Use (OAS-M) — 7.86; 15.73; 8.88 units on a scale — p=0.622
Intermittent Explosive Disorder
Primary: Safety and Tolerability — 28; 21; 0; 0 participants
Intermittent Explosive Disorder · Childhood Aggression · Oppositional Defiant Disorder
Primary: Number of Participants That Were Responders — 0; 5 Participants
Borderline Personality Disorder
Primary: Self-Report of Difficulties in Emotion Regulation (DERS) — 101.5; 54.8; 120.5; 56.6 units on a scale — p=<0.004
Substance-related Disorders · Violence
Primary: Addiction Severity Index Legal Composite — .038; .012 units on a scale
Major Depressive Disorder
Primary: SQ Anger/Hostility Scale — 4.8; 8; 6.7; 7.5 Score on Anger/Hostility Scale
Mood Disorder · Disruptive Behavior Disorders
Primary: Change in Affective Reactivity Index - Youth (ARI-Y) — -2.9; -0.8 score on a scale
Anger Problems
Primary: Least Squares Mean Anger Expression Index Score on the State Trait Anger Inventory 2 (STAXI-2) Using a Repeated Measures ANCOVA Adjusted for Baseline and Time Effects…
Posttraumatic Stress Disorder · Anger
Primary: Feasibility as Measured by Percentage of Recruitment Goal Met — 16; 14 participants
Chronic Post-Traumatic Stress Disorder
Primary: Overt Aggression Scale — 14.2 events
Attention Deficit Hyperactivity Disorder (ADHD)
Primary: Efficacy and Safety of SPN-810 on the Frequency of Impulsive Aggression (IA) Measured by the Impulsive Aggression Diary — -48.16; -47.88; -58.56 percent change of IA…
Traumatic Brain Injury
Primary: Post-Treatment Response Rate From Baseline on Anger Measures - Participant Report — 46.7; 68.3; 21.7; 50.0 percentage of participants — p=0.047
Irritable Mood · Mood Disorders
Primary: Change in Interpretation Bias — 1.53; 0.55 units on a scale — p=<0.001
Attention Deficit Hyperactivity Disorder (ADHD)
Primary: Efficacy and Safety of SPN-810 on the Frequency of Impulsive Aggression (IA) Measured by the Impulsive Aggression Diary — -54.12; -51.64 Percent Change of IA behaviors…
Internet Gaming Disorder
Primary: Percentage of Participants Who Completed All 6 Sessions — 40.6 percentage of participants
Major Depressive Disorder · Irritability
Primary: Change From Baseline to Week 6 in SIS Total Score — -21.13 units on a scale
Aggression · Anger · Posttraumatic Stress Disorder
Primary: Change in Mean Scores on the Conflicts Tactics Scale (CTS) From Baseline to Post-treatment, 3 Month and 6 Month Follow-up. — 0.50; 1.24; 0.22; 1.06 units on a scale…
Traumatic Brain Injury
Primary: Neuropsychiatric Inventory-Irritability Domain - Observer-rated Proportion Improved ≥ 3 Points Baseline to Day-91 — 30; 31 Participants
Impulse Control Disorder · Parkinson Disease
Primary: Percentage of Participants Assessed as Very Much Improved or Much Improved Based on the Clinical Global Impression-Improvement (CGI-I) Scale — 54.4; 33.1 percentage of…
Borderline Personality Disorder · Emotional Problem
Primary: Maternal Emotion Dysregulation — 82.35; 91.8 score on a scale — p=.002
Anger · Aggression
Primary: State Anger Scale — 27.34; 26.88; 23.47; 25.67 units on a scale — p=.14