Phase 4 N=89 Probiotics to Promote Intestinal Health
Communicable Diseases · Infection · Anti-Infective Agents
Primary: Number of Participants With Acquisition of Any New Antibiotic-resistant Organism — 9; 12 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=16 Diet Induced Intestinal Mucosal Adaptation
Healthy Conditions
Primary: Mucosal Surface Enlargement — 10.2; 9.9 percentage of muscular mucosae — p=<0.05
N/A N=107 Use of a Novel Synbiotic to Change Human Gut Bacteria and Improve Health in Obese Adults
Intestinal Microbiota and Barrier Function
Primary: Change in Microbiota, as Measured by Change in Microbiota Composition, Including Presence of B. Adolescentis BD1 and B. Animalis Supsp Lactis BB-12 — 7.9; 9.1; 8.8; 6.0…
Phase 4 N=40 Vitamin D and Prebiotics for Intestinal Health in Cystic Fibrosis
Cystic Fibrosis · Dysbiosis
Primary: Shannon Index — 5.02; 4.96; 5.28; 5.73 Shannon index
N/A N=92 Dietary Supplement With and Without a Probiotic and/or Antibiotic
Healthy Adults
Primary: Evaluation of the Changes in Microbiome Species Abundance and Diversity From Baseline Until End of Study (Day 35) — 27.00; 31.25; 27.00; 27.00 copies/ng DNA — p=<0.0001
N/A N=62 Dietary Supplement With and Without a Probiotic
Healthy Adult Subjects
Primary: Evaluation of the Levels of B.Infantis in Stool by Quantitative PCR — 3.33; 3.33; 3.33; 3.33 copies/ng DNA — p=<0.0001
N/A N=20 Human Pilot Study - HA35 (Hyaluronan Molecular Weight 35) Dietary Supplement for Promoting Intestinal Health
Gastrointestinal Microbiome
Primary: Composition of Stool Micro Biome Diversity and Phylogenetic Distribution at 0 Days, 8 Days and 28 Days — 0.697; 0.722; 0.735; 0.146 ratio
N/A N=52 Promoting Gastrointestinal Health and Reducing Subclinical Inflammation in Obese Individuals
Obesity · Overweight
Primary: Change in Interleukin-6 (Value at Week 8 Minus Value at Week 0) — 0.35; -1.08; 0.51 pg/mL — p=0.9942
N/A N=50 Safety, Tolerability, and Biosignature of Humanized Prebiotics in Healthy Adults
Intestinal Health
Primary: Mean Composite PROMIS Maximum Scores — 4.3; 5.0; 3.0; 4.4 score on a scale
Phase 2 N=24 Fermented Milk Drink on Human Intestinal Microflora
Signs and Symptoms, Digestive
Primary: Modification of the Composition of the Intestinal Microflora: Bifidobacterium — 7.88; 7.60; 8.13; 8.10 log10 CFU/g — p=<0.05
Phase 1 N=21 Effect of Bismuth Subsalicylate on the Gut Microbiome and Host Response in Healthy Adults
Healthy Adults
Primary: To Evaluate the Effect of BSS on the Human Gut Microbiome. — 2 Number of different bacterial taxa — p=<0.05
N/A N=58 Almonds: Digestive Health and Immune Function of Adults and Children
Healthy
Primary: Gut Microbiota Community Composition — -.0116; -0.407; -0.161; -.0498 log (CFU)
N/A N=103 Effects of Probiotics in Immune System of Healthy Adults
Conditions Influencing Health Status
Primary: Gastrointestinal Tolerance After Probiotic Consumption. — 20; 20; 20; 20 participants
N/A N=40 Impact of Symbiotic Administration on Intestinal Function of Head and Neck Patients Surgically Treated
Head and Neck Cancer · Synbiotics · Nutrition Therapy
Primary: Serum DAO Enzyme Concentration — 3; 2.5 ng/mL
Phase 2 N=94 Inulin for Infections in the Intensive Care Unit
Antibiotic Resistant Infection · Nosocomial Infection · Pathogen Transmission
Primary: Within-individual Change in SCFA Producer Level — -0.0; -1.8; 1.1 percentage of SCFA producers
Phase 1 N=44 Intestinal Permeability in Preterm Infants
Prematurity · Intestinal Permeability
Primary: Intestinal Permeability — 0.0731; 0.0720 ratio — p=0.932
Phase 1 N=12 Effect of Prebiotics on the Gut Microbiome Profile and Beta Cell Function
Type 1 Diabetes
Primary: Change in the Gut Microbiome Profile — 818.5; 229; 1610; 177 species count
N/A N=39 Biomarkers for Intestinal Permeability in Patients With Constipation
Intestinal Diseases · Irritable Bowel Syndrome · Constipation
Primary: Lactulose:C13 Mannitol Excretion Ratio 8-24hrs. — 0.01; 0.02 Ratio — p=0.87
Phase 1 N=27 CampETEC Hyperimmune Bovine Colostrum (HBC)
Healthy Volunteer
Primary: Incidence of Adverse Events — 1; 1; 0; 1 events
N/A N=25 The Effect of Fruit/Vegetable Drinks on the Human Intestine
Intestinal Bacteria Flora Disturbance
Primary: Change in Colonic Flora Composition — 52.4; 41.2; 41.4; 51.9 percentage of total bacteria — p=0.014
Phase 4 N=39 Gastric Acid Suppression and Probiotic Colonization
Probiotics
Primary: Relative Abundance of VSL#3 Probiotic Bacterial Strains When Ingested in the Presence or Absence of the Proton Pump Inhibitor (PPI) Omeprazole at Week 4. — 1.002; 0.8186…
N/A N=49 Probiotics for Liver Cirrhosis With Portal Hypertension
Liver Cirrhosis · Portal Hypertension
Primary: Admission Due to Complications Related to Portal Hypertension — 2; 3 participants — p=0.25
N/A N=13 Effects of Adding Chickpeas to the American Diet on Fecal Microbiota Composition and Markers of Inflammation
Inflammation
Primary: Changes in Diversity of Gut Microbiota 16S rRNA Gene Sequences With Regard to Time. — 316.383; 302.400; 283.058 Avg. Operational Taxonomic Units
N/A N=67 A Dietary Intervention Study on the Microbiome in Crohn's Disease Patients
Crohn Disease
Primary: Maintenance of Symptomatic Remission, Without Worsening of Any Existing Disease Activity During Study Period — -31.63; -27.57 score on a scale — p=0.469
N/A N=288 Prebiotic GOS and Lactoferrin With Iron Supplements
Iron-deficiency
Primary: Ratio of Harmful to Beneficial Bacterial Genera in Fecal Microbiota as Determined by Quantitative Polymerase Chain Reaction (qPCR) at 1 Month — 2.208; 1.530; 2.075…
N/A N=250 Calcium: Magnesium Balance, Microbiota, and Necroptosis and Inflammation
Colorectal Cancer
Primary: Comparisons of the Changes of Genera Prevotella by Mg Treatment vs. Placebo in Rectal Mucosa, Swab and Stool Samples — 0.108; 0.245; -0.076; 0.132 percentage of sample…
Phase 2 N=60 Fecal Microbiota Transplantation for Pancreatitis
Acute Pancreatitis · Intestinal Bacteria Flora Disturbance · Intestinal Dysfunction
Primary: Number of Participants With Gastrointestinal Failure Score Equal 0 — 12; 14 Participants
N/A N=24 Probiotics in Infants With Gastroschisis
Gastroschisis
Primary: Composition of the Fecal Microbiota — 42; 12; 1.1; 14 percentage of total bacteria — p=<0.01
N/A N=83 Evaluation of Bacillus Subtilis R0179 in Healthy Young Adults
Healthy
Primary: Evaluation of the Effect of B. Subtilis R0179 on Wellness Questionnaires for GI Distress — 0.5; 0.3; 0.6; 0.7 units on a scale
N/A N=34 The Effect of Concord Grape Polyphenol-soy Protein Isolate Complex (GP-SPI) on Gut Microbiota
Mechanisms, Defense
Primary: Gut Microbiota Composition — 58; 30; 0.04; 7.3 percentage of bacterial phyla