Clinical Trial Search

Primary: Change in Pain Intensity From Baseline (Pre-Operative) to Immediately During the Procedure (Day 0), Measured by the Visual Analogue Scale (VAS) — 5.05; 0.64 score on a…

Primary: Percent of Patients With Success as Defined by no or Mild Pain as Analyzed on a VAS Scale and no Narcotic Use — 52; 43 percentage of participants

Primary: VAS Scores as Measures of Profoundness of Pulpal Anesthesia — 3.1; 1.2 Score on a scale

Primary: Parameters Evaluated After Treatment — 19; 19; 25; 3 Participants

Primary: Clinical Success at 6 Months — 27; 30 Participants

Primary: Hypersensitivity Tactile(Yeaple Probe) — 19.81; 13.94 units on a scale — p=0.05

Primary: Number of Participants With Successful Injection Technique Assessed by Verbal Rating Scale (VRS) — 16; 37; 29; 26 Participants

Primary: Subjective Tooth Assessment: Number of Teeth With Normal and Abnormal Pulp — 111; 32 Teeth

Primary: Percent of Patients With Successful Anesthesia (% of Patients Able to Have Treatment Without Additional Anesthesia) — 16; 20 Participants

Primary: Success Rate Based on Pulp Vitality Tests (Vital/Non Vital) — 96.2; 100; 100; 86 Percentage of success rate — p=>0.1

Primary: Pain as Assessed by the Visual Analog Scale — 0; .33 score on a scale

Primary: Sum Pain Intensity Difference Scores — -2.4292; -68.0778; -68.3533; -93.3645 score on a scale

Primary: Ranked Endpoints : 1. Sum of Pain Intensity Differences at 6 Hours (SPID0-6h) — 8955.4; 8458.0; 5290.7 score on a scale — p=0.0031

Primary: Visual Analogue Scale (VAS) — 4.06; 2.68; 2.41; 2.27 score on a scale

Primary: 24 Hour Postoperative Pain for Patients Seen From 09/2020-06/2021 — 14.75; 16.23 score on a scale — p=0.63

Primary: Analgesic Efficacy, as Measured by the Sum of Pain Intensity Differences (SPID) Scale — 14.80; 0.40 Units on a scale — p=<0.0001

Primary: Post Operative Pain — 3.18; 2.27; 2.20; 1.39 score on a scale — p=0.083

Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05

Primary: Analgesic Efficacy From 0 to 6 Hours After the Dose Using the Time-weighted Sum of Pain Intensity Difference (SPID 0-6) — 4.37; 20.75; 8.95; 20.56 units on a scale…

Primary: Pain Intensity Measure: Visual Analogue Pain Scale — 11.8; 8.8; 9.4; 10.3 score on a scale — p=0.329

Primary: Tooth Hypersensitity to Touch Stimuli (Tactile) — 10.83; 10.63 Units on a scale — p=0.05

Primary: Change From Baseline in Evaporative Air Sensitivity Pain Response on a Schiff Sensitivity Scale at Day 14 — -1.20; -0.37 Score on a scale — p=<0.0001

Primary: Total Pain Relief From 0 to 6 Hours (TOTPAR[6]) — 6.94; 6.21; 7.00; 14.43 units on a scale

Primary: Change From Baseline in Schiff Sensitivity Score at Week 8 (Treatment 1 and 2 Versus [vs.] Placebo) — 2.51; 2.53; 2.54; -1.57 Score on scale — p=<0.0001

Primary: Anesthetic Success Rate of Supplemental Infiltration Injection — 22; 25; 23; 12 Participants — p=.901

Primary: Change From Baseline in Area Under the Curve (AUC) of Pain Intensity and Relief Scores (SPRID) — 2.68; 3.30; 2.62; 1.93 units on a scale*hour — p=<0.0001

Primary: Mean Change From Baseline in Evaporative Air Sensitivity Pain Response on a Schiff Sensitivity Scale at Week 8 — -0.9; -0.5 Score on a scale — p=<0.0001

Primary: Time Weighted Sum of Pain Intensity Difference (PID) Over 10 Hours (SPID 0-10) — 5.745; 30.986 units on a scale — p=<0.001

Primary: Number of Teeth Sensitive to Percussion in 3 Groups — 7; 6; 3 teeth — p=>0.05

Primary: Heft Parker Visual Analog Scale Pain Scale Pain Measurements — 63; 60 units on a scale