N/A N=71 Molecular Pathways Involved in Knee Pain
Knee Osteoarthritis · Knee Pain Chronic
Primary: Pain Sensitivity: Pressure Pain Detection Threshold (PPT) — 252.58; 266.17 kPa
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=53 Glucosamine and Chondroitin for Aromatase Inhibitor Induced Joint Symptoms in Women With Breast Cancer
Breast Cancer · Joint Pain
Primary: Change in WOMAC Score — 24.9 Score on a scale — p=0.004
Phase 3 N=164 A Study on Visco-antalgic Intra-articular Administration in Symptomatic Knee Osteoarthritis
Knee Osteoarthritis
Primary: Change From Baseline in WOMAC VA3.1 Pain Subscale Score at Month 6 — -23.6; -14.1 mm — p=0.141
Phase 2 N=260 Exploratory Study of PENNSAID Gel to Treat Symptoms of Knee Osteoarthritis
Osteoarthritis of the Knee
Primary: Pain When Walking On A Flat Surface — 0; 1; 8; 4 Participants
Phase 4 N=114 Arthralgia During Anastrozole Therapy for Breast Cancer
Early Breast Cancer
Primary: Number of Participants With New Events of Arthralgia — 37 Participants
N/A N=23 Jointstrong Intervention for Juvenile Arthritis
Juvenile Arthritis
Primary: Pain — 4.3; 5.7 units on a scale
Phase 4 N=200 Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection
Chondromalacia · Osteoarthritis · Traumatic Arthritis
Primary: 100 mm Visual Analogue Score (VAS) — 32.11; 41.14 score on a scale
N/A N=80 Knee Bracing for People With Patellofemoral Osteoarthritis
Knee Osteoarthritis
Primary: Change in Pain on the VIsual Analog Scale (VAS) — -.068 change in units on a scale from baseline
Phase 2 N=42 A Phase 1/2A, Single Dose Study Of PF-04383119 In Japanese Patients With Moderate To Severe Pain From Osteoarthritis Of The Knee
Osteoarthritis, Knee
Primary: Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs) — 9; 4; 9; 8 Participants
Phase 2 N=157 Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study In Subjects With Osteoarthritic Pain Of The Knee
Osteoarthritis, Knee
Primary: Change From Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Domain Score at Week 2 — -3.64; -3.15 Units on a scale — p=0.39
N/A N=100 Associated Joint Pain With Controlled Ankle Movement (CAM) Walker Boot Wear
Pain · Ankle Injuries
Primary: The Presence and Severity of Secondary Site Pain — 31 Participants
N/A N=25 MONOVISC for Ankle Joint Pain Relief Due to Osteoarthritis
Osteoarthritis Ankle
Primary: Numerical Rating Scale (NRS) Pain on Walking — -3.00 score on a scale — p=<0.0001
Phase 3 N=289 Efficacy of Web-based Pain Self-management for Adolescents With Juvenile Idiopathic Arthritis
Juvenile Idiopathic Arthritis
Primary: Change in Pain Intensity — 3.56; 3.26; 3.07; 2.90 Units on a scale — p=<.001
Phase 4 N=120 Osteoarthritis Knee Pain Relief Study of 0.25% 920-CGS-200
Osteoarthritis, Knee
Primary: Percentage of Subjects With 50% or Greater Pain Score Reduction From Baseline to 24 Hours After First Dose of Study Drug Treatment. — 27.03; 20.0; 23.08; 20.0 percentage…
N/A N=25,871 Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee Pain
Autoimmune Diseases · Systemic Inflammatory Process · Knee Pain Chronic
Primary: Serum Levels of Biomarkers of Systemic Inflammation: Interleukin-6 (IL-6) — 1.71; 1.68; 1.69; 1.70 pg/ml — p=0.02
Phase 2 N=51 Double-Blinded Clinical Trial Using Apatone®B for Symptomatic Postoperative Total Joint Replacements
Edematous · Synovitis · Foreign Body Reaction
Primary: Pain Visual Analog Scale (VAS) — 57; 46.8; 39.7; 39.1 units on a scale — p=0.0063
N/A N=20 Geniculate Artery Embolization for the Treatment of Knee Pain
Osteoarthritis Of Knee
Primary: Patient Function (Units on a Scale) — 31 units on a scale
Phase 2 N=40 Krill Oil for Pain in Elders
Chronic Musculoskeletal Pain
Primary: Participants With 70% or Greater Adherence Based on Self-reported Daily Diary — 18; 17 Participants
N/A N=110 Home-Based Exercise and Weight Control Program for Pain Control in Overweight Elderly With Osteoarthritis of the Knee
Chronic Diseases · Obesity · Osteoarthritis
Primary: WOMAC Function — -10.4; -4.8; -4.9; -1.6 Change in Score — p=0.0129
N/A N=41 Hip Osteoarthritis: Effects of Exercise Programs on Pain and Disability
Hip Osteoarthritis
Primary: Change in 6-minute Walk Test — 22; 49 meters
Phase 2 N=41 A Pilot Study Assessing the Treatment Responsiveness of a Novel Osteoarthritis Stiffness Scale
Osteoarthritis, Knee
Primary: Sum of Change in Brief Arthritis Stiffness Scale (BASS) Scores Over the 4-day Treatment Period — -12.6; -13.6; -11.7; -2.3 Scores on a scale
N/A N=25 MONOVISC for Hip Joint Pain Relief Due to Osteoarthritis
Osteoarthritis, Hip
Primary: Numerical Rating Scale (NRS) Pain on Walking — -3.68 score on a scale — p=<0.0001
N/A N=19 Feasibility of Pain Informed Movement for Knee OA
Knee Osteoarthritis
Primary: Acceptability of Content — 13 Participants
N/A N=90 Resistance Exercise and Knee Osteoarthritis Pain, Functional Impairment and Cartilage Turnover
Knee Osteoarthritis
Primary: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Score); Change From Baseline at 4 Months — 27.1; 33.3; 28.9; 26.7 units on a scale
N/A N=25 MONOVISC for Shoulder Joint Pain Relief Due to Osteoarthritis
Osteo Arthritis Shoulders
Primary: Numerical Rating Scale (NRS) Pain — -4.12 score on a scale — p=<0.0001
N/A N=32 Effects of UC-II, Glucosamine and Curcumin Supplementation on Knee Pain and Inflammation.
Inflammation · Knee Pain Chronic
Primary: Points Change of Pain Evaluation Scale — 1.49; 1.15; 1.15; 1.14 score on a scale — p=0.478
Phase 2 N=100 Vitamin D Deficiency, Muscle Pain, Joint Pain, and Joint Stiffness in Postmenopausal Women Receiving Letrozole For Stage I-III Breast Cancer
Arthralgia · Musculoskeletal Complications · Pain
Primary: Number of Early Breast Cancer Patients Prescribed Adjuvant Letrozole That Are Vitamin D Deficient and Who Experience Myalgias, Arthralgias and/or Joint Stiffness — 12; 1…
N/A N=50 Osteoarthritis Structural Changes Assessed by Magnetic Resonance Imaging and Neuropathic Pain in Knee Osteoarthritis
Neuropathic Pain · Knee Osteoarthritis
Primary: Osteoarthritis Structural Changes Assessed by Quantitative Magnetic Resonance Imaging With and Without Neuropathic Pain — 14; 7; 5; 1 participants
N/A N=34 Inflammation and Insulin Resistance in Rheumatoid Arthritis
Rheumatoid Arthritis
Primary: Disease Activity Score Based on 28-joint Disease Activity Score (DAS28) — 4.40; 4.03; 4.57; 4.48 units on a scale
Phase 3 N=64 Hyaluronic Acid in Overuse Knee Pain
Overuse Injury · Body Mass Index in Athletes
Primary: Efficacy of Hyaluronic Acid With Sorbitol (SYNOLIS VA) in Overuse Knee Syndrome Assessed With the Knee Injury and Osteoarthritis Outcome Score (KOOS) — 68; 78; 84; 88…