Phase 4 N=40 Dexmedetomidine and Propofol for Pediatric MRI Sedation
Headache · Tumor · Seizure Disorder
Primary: Efficiency of Propofol Dexmedetomidine Sedation Compared With Propofol Infusion — 98; 77 minutes
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=60 Conscious Sedation for Epilepsy Surgery
Epilepsy
Primary: Patients Satisfaction — 6.33; 6.45 score on a scale
N/A N=36 Sedatives' Effects on Neurological Function in Patients With Eloquent Area Glioma
Glioma
Primary: Task Completing Time Change Between Sedation and Baseline Measured by 9-hole Peg Test — 27.8; 19.1; 54.3; 21.4 seconds — p=<0.01
Early Phase 1 N=300 Sedation Regimens in GI Endoscopy
Anesthesia · Endoscopy · Colonoscopy
Primary: Pain Felt During the Procedure — 0.29; 0.30 score on a scale
Phase 4 N=71 A Pilot Study of Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging
Epilepsy · Cerebral Palsy · Developmental Delay
Primary: Dosage/Consumption — 0.36; 0.25 mcg/kg/min
N/A N=86 Sedation and Pain (The Effect of IV Sedation on Pain Perception)
Pain
Primary: Pain Rating Change — -0.253; 0.762; -0.346 units on a scale
N/A N=49,733 Reduction of Claustrophobia and Patient Motion After Training of MRI Personnel in Comfort TalkTM
Claustrophobia · Complication of Diagnostic Procedure
Primary: Change in Non-completion Rate of MRI Scans From the Average of the Baseline Year to the Average of One Year Post Training (All Scheduled Patients) — 10; -3.3 Percentage…
N/A N=7,604 Comfort Talk and Economic Outcomes in MRI
Claustrophobia · Complication of Diagnostic Procedure
Primary: Equipment Utilization Q4FY15 = Baseline Quarter (OSU) — 0.83; 0.77 Proportion of completed scans per slots
N/A N=120 Pediatric Temperature Variation in the MRI Scanner Under General Anesthesia
Children Requiring MRI
Primary: Change in Body Temperature in Children Undergoing MRI Under General Anesthesia (GA)and Change in Room Temperature Before and After MRI — 36.7; 36.3; -0.4; 21.1 celsius…
Phase 2 N=232 Myocardial Perfusion MRI
Myocardial Perfusion Imaging · Magnetic Resonance Imaging
Primary: Percentage Agreement Between Gadobutrol Perfusion Magnetic Resonance Imaging (MRI) (Blinded Reading) and SPECT (Central Reading) Regarding the Diagnosis for Detection of…
N/A N=45 MRI for Non-Invasive Imaging in Neonates and Children
Healthy · Cystic Fibrosis (CF) · Asthma
Primary: Ventilation Defects as Seen on Hyperpolarized Helium-3 MRI — 9; 13; 16 Participants
Phase 2 N=57 Study to Find the Appropriate Dose of a New Gadolinium-based Contrast Agent (GBCA) for Adults Undergoing Magnetic Resonance Imaging (MRI) for Known or Highly Suspected Brain and/or Spinal Cord Conditions
Central Nervous System Pathology
Primary: Overall Diagnostic Preference — 10; 34; 56; 26 Percentage of participants — p=<0.0001
Phase 4 N=32 Magnetic Resonance Imaging of the Effect of Music Listening on Brain Activity Under Anesthesia
Healthy
Primary: Blood Oxygen Level Dependent (BOLD) Response to Sensory Stimuli During Sedation — 0.04; 0.01 arbitrary units — p=<0.001
N/A N=239 ENABLE MRI (Magnetic Resonance Imaging)
Magnetic Resonance Imaging
Primary: Percentage of Participants Free From MR (Magnetic Resonance) Scan-related Complications — 100 percentage of participants
N/A N=20 Combined Electroencephalogram, Magnetic Resonance Imaging-Positron Emission Tomography of Dexmedetomidine Induced Sleep
Dexmedetomidine Induced Sedation
Primary: Number of Participants With Changes in the Brains Default Mode Network. — 16 participants
Phase 4 N=128 Safety and Efficacy of Dexmedetomidine (DEX) for Sedation of Subjects ≥1 Month to <17 Years Undergoing MRI Scans
MRI Sedation
Primary: Percentage of Participants at the DEX High Dose Versus Low Dose in the Combined Age Cohorts Who Did Not Require Concomitant PRO to Complete MRI — 63.2; 14.3 Percentage…
Phase 4 N=50 Alternative Sedation During Bronchoscopy
Sedation
Primary: Decreased Minute Ventilation — 0.736; 0.764 percentage of baseline — p=<0.0001
N/A N=263 Advisa MRI Clinical Study
Magnetic Resonance Imaging · Cardiac Pacemaker, Artificial
Primary: Magnetic Resonance Imaging (MRI)-Related Complications — 0 participants — p=<0.0001
Phase 3 N=50 Sedation Using Intranasal Dexmedetomidine in Upper Gastrointestinal Endoscopy
Gastrointestinal Disease
Primary: Consumption of Rescue Patient Controlled Propofol — 42.4; 28.6 mg
N/A N=146 Virtual Reality as a Substitute for Procedural Sedation During Epidural Steroid Injections
Lower Back Pain · Lumbar Radiculopathy
Primary: Pain Score During Procedure — 3.7; 3.2; 5.2 score on a scale
Phase 4 N=105 Sedation Methods During Cataract Surgery
Phacoemulsification · Cataract
Primary: Eye Mobility During Surgery (See Link to Study Protocol for Scale) — 1.39; 1.41; 1.31 units on a scale
N/A N=26 Sensory Effects of Rapidly-Changing Magnetic Fields
Sensory Disorders
Primary: Degree of Discomfort Under Applied Pulsed Magnetic Fields — 0 percentage of subjects with discomfort
N/A N=1,509 Clinically Indicated Magnetic Resonance Imaging in Patients With Cardiac Devices
Arrhythmias, Cardiac
Primary: Device Malfunction — 24; 52 Participants
N/A N=63 China 3T MRI Study
Bradycardia · Tachycardia · Heart Failure
Primary: The Occurrence of an MRI-related Event for CIED — 59; 0 Participants — p=0.002
Phase 4 N=44 Eovist vs. Dotarem Healthy Volunteer MRI
Transient Severe Arterial Phase Motion
Primary: Subject Breath Hold Capacity, as Measured by Number of Seconds a Subject Can Hold His/Her Breath — 28; 38; 35 seconds
N/A N=73 Effect of Sedation on Diagnostic Injections
Sacroiliac Joint Pain · Sympathetically Maintained Pain
Primary: Pain Score — 2.2; 3.4 units on a scale
Phase 4 N=60 A Comparison of Intranasal Midazolam and Nitrous Oxide (N2O) Minimal Sedation for Minor Procedures in a Pediatric Emergency Department
Conscious Sedation · Simple Lacerations Less Than 4 cm · Lumbar Punctures
Primary: ED Length of Stay After Intranasal Midazolam or Nitrous Oxide Administration — 24.5; 18.5; 9; 10 minutes
N/A N=16 Dynamic Magnetic Resonance Imaging (MRI) for Lung Tumor Motion and Lung Function (GCC 0943)
Lung Cancer
Primary: Number of Participants Whose Tumor Position is Visible Within ~2mm Using Cine-MRI Scans and External Sensors — 7 participants
Phase 1 N=140 A Study of Magnetic Resonance Imaging (MRI) With Gadavist in Children
Magnetic Resonance Imaging
Primary: Plasma Clearance Estimates of Gadobutrol by Age Group — 2.07; 3.28; 4.90; 3.24 L/h
Phase 4 N=103 The Effect of Different Sedation Regimes on Cognitive Function in Lower Gastrointestinal System Endoscopy
Gastrointestinal Dysfunction · Alteration of Cognitive Function
Primary: Change in Cognitive Function — 47.5; 40.4; 44.7; 37.8 units on a scale — p=0.001