N/A N=60 Medication-overuse Headache: 4 Years Follow up
Medication Overuse Headache
Primary: Change in Headache Days/Month After 4 Years Compared to Baseline — 6.6 headache days/month
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=79,560 Telemedicine Control Tower for the Operating Room: Navigating Information, Care and Safety
Surgery · Surgery--Complications · Perioperative/Postoperative Complications
Primary: Thirty-day Postoperative Mortality — 899; 866 Participants — p=0.41
N/A N=190 Opioid Prescribing After Cesarean Delivery
Surgery · Opioid Use
Primary: Unused Opioids — 5; 10 oxycodone 5mg tablets
N/A N=61 Medication-overuse Headache (MOH): Withdrawal or Use of Preventative Medications Directly?
Headache
Primary: Headache Days — 7.2; 4.2; 1.6 days/month — p=0.056
N/A N=299 Primary Care Intervention to Reduce Prescription Opioid Overdoses
Pain · Drug Overdose · Opioid Use Disorders
Primary: Overdose Risk Behaviors — 1.31; 1.21; 1.45; 1.25 score on a scale
N/A N=201 Optimizing Electronic Health Record Prompts With Behavioral Economics to Improve Prescribing for Older Adults
Aging · Benzodiazepine Sedative Adverse Reaction · Anticholinergic Adverse Reaction
Primary: Change in Inappropriate Prescribing by Study Arm: Descriptive Comparison Across Study Arms — 35.2; 33; 35.6; 40.6 percentage of patients
Phase 2 N=120 Ambulatory Gynecologic Surgery: Finding the Optimal Opioid Prescription
Surgery
Primary: Number of Oxycodone Tablets Used Day 1 — 1.0; 1.0 Oxycodone Tablets — p=.87
N/A N=127 Post-op Crowd Sourcing Health Data Via Text-messaging
Orthopedic Surgery · Opioid Use · Acute Injuries Knee
Primary: Number of Opioid Tablets Taken Within 28 Days — 8.05; 11.55 number of pills taken
N/A N=720 The MOTS (Medication Overuse Treatment Strategy) Trial
Migraine
Primary: Frequency of Moderate to Severe Headache Days — 9.3; 9.1 days
N/A N=204 Safety & Prevention Outcomes Study
Drug Overdose · Opioid-Related Disorders
Primary: Overdose Risk Behavior — -1.54; -0.51 Scores on a scale
N/A N=1,146 NUDGE-EHR Replication Trial at Mass General Brigham
Aging · Benzodiazepine Sedative Adverse Reaction · Anticholinergic Adverse Reaction
Primary: Change in Inappropriate Prescribing — 106; 145; 122 Participants — p=0.002
Phase 4 N=608 A Study of Eptinezumab in Participants With Migraine and Medication Overuse Headache
Migraine · Medication Overuse Headache
Primary: Placebo-controlled Period: Change From Baseline in the Number of MMDs at Weeks 1 - 4 — -6.85; -3.66 days/month — p=<0.0001
N/A N=1,045 Using Behavioral Economics to Reduce Low-Value Care
Pre-Operative Testing for Cataract Surgery
Primary: Pre-Operative Testing Change — 87.4; 85.0; 86.1; 85.4 Percentage of patients with orders
N/A N=851 Behavioral Insights to Encourage Judicious Prescribing of Opioids
Substance-Related Disorders
Primary: Average Change Over Time in Dispensed Narcotics — 347.65; 350.09; 288.36; 318.60 Morphine milligram equivalents — p=<0.05
N/A N=2,780 Realtime Streaming Clinical Use Engine for Medical Escalation
Clinical Deterioration · Hospital Medicine · Monitoring, Physiologic
Primary: Overall Rate of Escalation — 12.3; 11.3 escalations per 1,000 patient bed days — p=< 0.001
N/A N=47 Integrative Medicine Consultation for Patients With Pain or Fatigue
Pain · Fatigue
Primary: Short Form 36 (SF-36) Physical Component Summary (PCS) — 36.2; 39.0 Scores on a scale — p=0.487
N/A N=286 Guiding Aging Long-Term Opioid Therapy Users Into Safer Use Patterns
Pain · Opioid Use
Primary: Count of Referrals to Non-opioid Care — 3.075; 3.61 Count of referrals — p=0.213
N/A N=1,525 The Effect of Informative Letters on the Prescription and Receipt of Schedule II Controlled Substances
Economics · Fraud · Delivery of Health Care
Primary: 30-day Equivalent Prescribing of Schedule II Controlled Substances — 461.1; 450.0 30-day equivalent prescription fills
Phase 4 N=304 Comparing Opioid Prescription Patterns in Total Joint Arthroplasty Patients
Postoperative Pain
Primary: Morphine Milligram Equivalents (MME) of Oxycodone Tablets Taken by Patient — 1089.7; 777.1 Morphine Milligram Equivalents (MME)
N/A N=664 Behavioral Economics Applications to Geriatrics Leveraging EHRs
Prostate Specific Antigen · Asymptomatic Bacteriuria · Type 2 Diabetes Mellitus
Primary: Misuse of Urinalysis or Urine Culture in Older Women — 25 Participants
N/A N=115 Opioid Treatment and Recovery Through a Safe Pain Management Program
Depression · Opioid Use · Chronic Pain
Primary: Odds of Morphine Equivalent Daily Dose (MEDD) of Opioid Prescription >=50 mg — 0.209; 0.417; 0.185; 0.364 odds of prescription high dose — p=0.956
N/A N=55 Clinical Decision Support for Opioid Use Disorders in Medical Settings: Usability Testing in an EMR
Opioid-use Disorder
Primary: Intervention PCP Confidence in Assessing and Treating OUD — 6; 11; 8; 1 Participants
N/A N=24 MIDAS Cluster Randomized Controlled Trial of Implementation Strategies to Optimize Use of Medications in VA Clinical Settings
Polypharmacy · Insomnia · Anticoagulants
Primary: Change in the Percentage of Patients With Potentially Inappropriate Medication Use (PIMs) Between Pre- and Post-periods, Across Facilities. — -0.133; -0.395 percentage…
N/A N=4 Improving Antimicrobial-Prescribing in Emergency Departments
Anti-Bacterial Agents · Respiratory Tract Infections
Primary: Percentage of Patient-visits Prescribed an Antimicrobial at Their ED Visit — 21.2; 20.9; 19.1; 21.6 percentage of visits prescribed an abx — p=0.35
N/A N=196 Discharge Opioid Education to Decrease Opioid Use After Cesarean
Opioid Use
Primary: Opioid Use — 7.5; 10 hydrocodone tablets
N/A N=52 The Medication Metronome Project - Study to Facilitate Follow-up Testing Resulting From Prescribed Medications to Improve Patient Safety and Care
Diabetes Mellitus, Type 2 · Hypertension · Hyperlipidemia
Primary: Primary Effectiveness Outcome - LDL — 57.9; 54.8 percentage of time spent at goal
N/A N=37,134 Behavioral Economics Applications to Geriatrics Leveraging EHRs R33 Trial
Prostate Specific Antigen Screening · Asymptomatic Bacteriuria · Type 2 Diabetes
Primary: PSA Screening in Older Men — 1675; 1373 Participants
N/A N=652 EHR-Based Medication Complete Communication Strategy to Promote Safe Opioid Use
Opioid Use, Unspecified
Primary: Safe Medication Dosing (Prescription Understanding) — 0.67; 0.83; 0.79 probability
N/A N=49 Consensus-based Algorithms to Address Opioid Misuse Behaviors Among Individuals Prescribed Long-term Opioid Therapy
Opioid Misuse · Chronic Pain
Primary: Feasibility of Algorithms — 7; 13 Participants
N/A N=541 Encouraging Judicious Prescribing of Opioids in Los Angeles County
Substance-Related Disorders
Primary: Average Weekly Change in Morphine Milligram Equivalents (MME) Dispensed — 157.70; 157.81; 103.16; 89.96 Estimated average weekly MME dispensed — p=<0.05