Phase 3 N=4 Comparing Buccal and Vaginal Misoprostol in Management of Early Pregnancy Loss
Spontaneous Abortion in First Trimester
Primary: Patient Enrollment — 2; 2 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=349 Walking and Dietary Modification for Recurrent Early Miscarriages
Recurrent Miscarriage
Primary: Take-home Baby Rate — 152; 83 babies
Phase 3 N=153 Misoprostol for Treatment of Fetal Death at 14-28 Weeks of Pregnancy
Intrauterine Fetal Demise
Primary: Successful Expulsion of Fetus and Placenta Within 48 Hours — 60; 47 participants — p=<0.05
N/A N=50 The Use of Cell Free Fetal DNA in the Maternal Blood in the Evaluation of Intrauterine Fetal Demise and Miscarriage
Circulating Cell Free Fetal DNA · Intrauterine Fetal Demise · Miscarriage
Primary: The Presence or Absence of Cell Free Fetal DNA in Maternal Blood in the Setting of a Failed Pregnancy. — 50 percentage of participants
Phase 4 N=211 Misoprostol 400 µg Versus 200 µg for Cervical Ripening in 1st Trimester Miscarriage
Miscarriage in First Trimester
Primary: Number of Participants Who Required Cervix Dilation at Initiation of the Manual Vacuum Aspiration — 4; 16; 102; 89 Participants — p=0.025
Phase 4 N=250 Pain Control In First Trimester Medical Abortion: A Randomized Trial
Pain
Primary: 11-point Visual Analog Scale for Pain — 7.1; 7.3 units on a scale
N/A N=10 Blood Loss at the Time of First Trimester Surgical Abortion in Anticoagulated Women
Blood Loss
Primary: Volume of Intraoperative Blood Loss — 91.5; 52.2 milliliters
Phase 3 N=300 Comparative Effectiveness of Pregnancy Failure Management Regimens
Spontaneous Abortion
Primary: Gestational Sac Expulsion With One Treatment Dose on Day 3 (Visit 2) and no Need for Additional Medical or Surgical Intervention Within 30 Days of Treatment. — 100; 124…
Phase 4 N=30 Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial
Abortion, Second Trimester · PPROM · Rupture, Spontaneous
Primary: Delivery Within 12 Hours — 5; 5 Participants
N/A N=251 Optimisation of the Management of Placental Delivery in Second Trimester Pregnancy Interruption
Placenta, Retained · Postpartum Hemorrhage
Primary: Placental Retention Rate — 26; 8; 24 participants — p=0.05
N/A N=30 Virtual Reality Experience in First Trimester D&C
First Trimester Abortion · Virtual Reality
Primary: Number of Participants Able to Use VR Device Throughout the Entire Duration of First Trimester Surgical Abortion. — 6 participants
N/A N=181 A Randomized Controlled Trial of Three Antibiotic Regimens for First Trimester Abortions
First Trimester Abortion
Primary: Nausea Scale — 8; 9; 6; 6 Participants
Phase 2 N=3 Ulipristal Acetate for Use in Early Pregnancy Loss
Missed Abortion · Anembryonic Pregnancy · Non-Viable Pregnancy
Primary: Percentage of Participants Recruited to Study Protocol — 37.5 percentage of participants
Phase 4 N=100 Same-Day Mifepristone-Misoprostol Compared to Misoprostol Only for Surgical Abortion Cervical Preparation
Induced Abortion
Primary: Initial Cervical Dilation — 11.7; 10.9 mm
Phase 4 N=124 Evaluation of Oral Midazolam in First-trimester Surgical Abortions
Pain · Anxiety · Nausea
Primary: Subject Perception of Pain and Anxiety During Uterine Aspiration — 74.3; 70.1; 68.2; 60.9 mm
Phase 4 N=70 24-hour Mifepristone and Buccal Versus Mifepristone and Vaginal Misoprostol for Cervical Preparation for D&E
Abortion, Second Trimester
Primary: Procedure Time — 9.5; 9.9 minutes
N/A N=254 Media, Morphokinetics, and Mosaicism
Embryonic Mosaicism · Embryo Culture Media · Embryo Morphokinetics
Primary: Aneuploidy Rates — 56.1; 62.3 percentage of embryos — p=0.07
N/A N=102 Iron Parameters in Non-anemic First Trimester Gravidas
Iron Deficiency (Without Anemia) · Pregnancy
Primary: Percent of Non-anemic Patients With Iron Deficiency Stratified by Gravidity — 9; 3; 6; 38 Participants
N/A N=51 The Role of a Semi-Quantitative Urine Pregnancy Test and Pregnancy Questionnaire After Uterine Evacuation for Undesired Pregnancy of Uncertain Location
Follow-up After Uterine Evacuation
Primary: Number of Women in Each Group Who Require a Return Visit to the Clinic for a Serum hCG Measurement, Ultrasound or Clinical Examination at One Week to Confirm Complete…
N/A N=128 Early Anatomy Scan for Evaluation of Obese Pregnant Women (EASE-O)
Obesity
Primary: Completion Rate for First Trimester Scans — 66 percent
Phase 4 N=121 Hydrocodone For Pain Control in First Trimester Surgical Abortion
Pain
Primary: Patient Perception of Pain — 65.7; 63.1 mm
N/A N=500 Study of the Sensitivity of Manual vs Electric Aspiration to Detect Completed Early Abortion
Induced Abortion
Primary: Accurate Confirmation of Completed Abortion — 182; 164 participants — p=.13
N/A N=50 Mifepristone Versus Laminaria Insertion for Cervical Preparation Prior to Surgical Abortion at 14-16 Weeks
Abortion
Primary: Time for Completion of Procedure — 8.0; 9.87 Minutes — p=0.05
N/A N=135 Fetal Fibronectin as a Predictor of Successful Induction of Mid-trimester Abortion
Medical; Abortion, Fetus
Primary: Cervicovaginal Fetal Fibronectin Level — 39.4 nanogram per milliliter
N/A N=634 Transabdominal and Transvaginal Sonography in Medical Abortion
Abortion Early
Primary: Percentage of Subjects in Each Ultrasound Group With Additional Testing — 63; 14 Participants
N/A N=452 Low Plasma Mannose Binding Lectin (p-MBL) Level is a Risk Factor for Recurrent Pregnancy Loss (RPL)
Recurrent Miscarriage · Spontaneous Abortion · Mannose-Binding Lectin Deficiency
Primary: Plasma MBL Level (ug/ml) — 717; 1717 ug/l — p=<0.001
N/A N=50 Value of Mifepristone in Cervical Preparation Prior to Dilation and Evacuation 19-24 Weeks
Abortion, Induced
Primary: Procedure Time — 10.9; 11.8 minutes
N/A N=77 Intravenous Immunoglobulin (IVIG) for Treatment of Unexplained Secondary Recurrent Miscarriage
Miscarriage, Recurrent · Abortion, Habitual
Primary: Number of Successful Pregnancies Defined as an Ongoing Pregnancy Over 20 Weeks Gestation, Per Number of Index Pregnancies — 16; 15 Successful pregnancies — p=<0.05
Phase 2 N=69 Cabergoline for Lactation Inhibition After Early Second-Trimester Abortion or Pregnancy Loss
Lactation Suppressed
Primary: Number of Participants Reporting Breast Pain — 16; 30 Participants
Early Phase 1 N=170 Effect of Metformin on Early Pregnancy Loss in Pregnant Women With Polycystic Ovarian Syndrome
Polycystic Ovary Syndrome
Primary: Miscarriage Rate — 9; 35 participants