Clinical Trial Search

Primary: Mitochondrial Function in Circulating Cells and Muscle Tissue in Young Women — 26.48; 30.46; 120.04; 140.43 pmol O2/min per 400K cells

Primary: Phosphocreatine (PCR) Recovery Time After Knee Extension Assessed by 31 Phosphorus Magnetic Resonance Spectroscopy (31P-MRS) — 60.59; 62.66 seconds

Primary: Change From Baseline in Phosphocreatine Recovery (ViPCr) at 6-months — 1.7; 1.6 mM/s — p=0.97

Primary: Change in Percentage of Liver Fat Per MRI — -13.93 percentage of liver fat

Primary: Perfused Vessel Denisty (PVD) — 22.8; 23.8; 20.2; 22.5 mm/mm^2

Primary: Change in Mitochondrial Network Complexity of Endothelial Cells as Measured by Mitochondrial Network Fragment Ratio

Primary: Mitochondrial Respiration Efficiency (as Measured by OCR). — 67.7167; 53.7000; 73.3358; 68.5789 picomole/minute — p=<0.01

Primary: Average TSST-induced Elevation in Cortisol — 37.44; 33.86; 42.83; 45.42 ng*min/mL

Primary: McMaster Gross Motor Function (GMFM 88) — -0.002; -0.12 units on a scale — p=0.95

Primary: Change of Peak Workload (in Watts/kg) During Exercise Testing — 0.0090; 0.020; -0.0300; 0.1050 Watts/kg — p=0.7321

Primary: Difference in Mitochondrial Respiratory Function — 36; 32; -3 pmols/s/mg — p=0.6051

Primary: Muscle Mitochondrial Function — 0.88; 0.90 mM ATP/s — p=0.15

Primary: Endothelial Function — 6.13; 3.78 % dilation

Primary: Change in Insulin Sensitivity — 3.18; 3.85; 3.57; 5.22 mg/kg.min per µU/ml

Primary: The 25-Item Hamilton Depression Rating Scale. — 23.3; 22.1; 17.5; 18.5 units on a scale

Primary: Change From Baseline in ATPmax (Maximal ATP Synthetic Rate) — 0.17; 0.12; 0.09; 0.06 mM/sec

Primary: Change in Mitochondrial Activity in Study Patients: Citrate Synthase — 40.56; 29.09; 27.41; 37.78 nmoles/min/mg protein

Primary: Insulin Sensitivity by Hyperinsulinemic Euglycemic Clamp — 3.27; 3.46 mg/kg/min

Primary: Newcastle Paediatric Mitochondrial Disease Scale (NPMDS) Part I-III, Baseline — 23.9; 20.4 Units on a scale

Primary: To Measure Different Mitochondrial Bioenergetic Markers, Including Basal Respiratory Capacity — 221.85; 151.14; 139.20 pmol/min

Primary: Phosphocreatine Recovery — -18.9; 7.7 percentage change from baseline

Primary: Change in Distance Walked (Meters) on the 6-minute Walk Test (6MWT) — 13.5; 36.5; 64.5; 20.4 meters

Primary: Distance Walked on the 6-minute Walk Test (6MWT) by Visit — 394.1; 378.2 meters

Primary: Phosphocreatine (PCR) Recovery Time After Exhaustive or up to 6 Minutes of Leg Exercise. — 0.0; 1.01 seconds — p=>0.05

Primary: The Number of Patients Who Enrolled Completed the Study. — 23; 10 Participants

Primary: Change in Limb Fat at 48 Weeks — 448; 153 grams — p=0.02

Primary: Change in PCr Recovery Tc Measurement From Baseline to 12 Week NR Supplementation Using the 31P-MRS Skeletal Muscle Submaximal Exercise. — 60; 73 Seconds

Primary: Change in Peak Oxygen Uptake. — 2.2; 2.8 ml/Kg/min — p=<0.05

Primary: Skeletal Muscle Mitochondrial Respiration State 3; Baseline to 12-week Change. — 2.2; -0.8 pmol O2/s/mg DW — p=0.9017

Primary: Maximal Aerobic Capacity- CoQ10 — 21.4; 20.7; 20.7 mL/min/kg — p=0.33