N/A N=23 Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Newly Diagnosed Patients
Nocturnal Hypoventilation · Neuromuscular Disease · Chest Wall Disorder
Primary: Overnight Mean Oxygen Saturation — 96; 96 % SaO2 — p=0.13
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=92 Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement (NREM) Sleep
Sleep Apnea · Age
Primary: Apneic Threshold (AT) and Carbon-dioxide (CO2) Reserve — 39.8; 36.7; -4.1; -2.6 mm Hg — p=<0.05
N/A N=20 High Intensity Non-Invasive Positive Pressure Ventilation (HINPPV)
Chronic Obstructive Pulmonary Disease (COPD)
Primary: Daytime Partial Pressure of Carbon Dioxide in Arterial Blood (PaCO2) — 53; 50 mmHg — p=0.01
N/A N=25 Servo-Ventilation In-lab PSG Evaluation
Sleep Apnea Syndromes
Primary: Average Apnea Hypopnea Index Among Different Polysomnography Devices. — 18.4; 25.4; 24.1; 19.2 events per hour
N/A N=68 Clinical Stabilization of Hypercapnia: NIPPV v HVNI
Hypercapnic Respiratory Failure · Chronic Obstructive Pulmonary Disease · Dyspnea
Primary: Rated Perceived Dyspnea [RPD] — 5.4; 5.6; 3.97; 4.54 units on a scale (0-10)
Early Phase 1 N=63 Respiratory and Autonomic Plasticity Following Intermittent Hypoxia
Sleep Apnea Syndromes
Primary: Ventilation (Aim 1) — 1.19; 1.14; 1.35; 1.16 fraction of baseline — p=0.001
Phase 4 N=14 Sleep and Breathing in the General Population - Chemical Stimuli
Sleep-disordered Breathing
Primary: The Central Apnea-hypopnea Index — 14.1; 29.9 events per hour
N/A N=74 Home-Based Diagnosis and Management of Sleep-Related Breathing Disorders in Spinal Cord Injury
Obstructive Sleep Apnea · Hypercapnia · Spinal Cord Injury
Primary: Prevalence of Sleep-disordered Breathing in Spinal Cord-injured Adults — 40; 23; 11 participants
N/A N=29 Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease
Amyotrophic Lateral Sclerosis (ALS) · Neuromuscular Diseases
Primary: Percent Change in Maximal Inspiratory Pressure (MIP) — 0.3; -3.1; -4.8; -5.0 percentage change in MIP from baseline
N/A N=54 Ketamine Infusion and Hypoventilation
Hypoventilation
Primary: Intraoperative Hypoventilation — 1.2; 65 % time
N/A N=29 Bipap Automatic Servo Ventilation (autoSV) Advanced in Central Apnea Patients
Cheyne-Stokes Respiration · Sleep Apnea, Central
Primary: Apnea/Hypopnea Index (AHI) — 55; 37; 12 Apnea-Hypopnea events per hour
N/A N=21 Adjustment of Mask Pressure, for Bilevel Positive Airways Pressure Therapy, by Automated Algorithm
Respiratory Insufficiency · Sleep Disordered Breathing
Primary: Index of Apneoas Plus Hypopnoeas Per Hour of Sleep (AHI) — 1.3; 1.7 Events per hour of sleep
N/A N=56 Use of Non-Invasive Positive Pressure Ventilation in Patients With Severe Obesity Undergoing Upper Endoscopy Procedures
Severe Obesity · Hypoxia
Primary: Percentage of Participants With an Oxygen Desaturation Event ≤ 94% — 57.1; 14.3 percentage of participants
N/A N=17 Sleep and Circadian Rhythms in Mechanically Ventilated Patients
Respiratory Failure · Critical Illness
Primary: Percentage of Subjects Who Successfully Undergo Continuous Bedside Polysomnography for at Least 24 Hours. — 9; 8; 5 Participants
Phase 3 N=38 Astral VAPS AutoEPAP Clinical Trial
Upper Airway Obstruction · Respiratory Insufficiency · Respiratory Failure
Primary: Oxygen Desaturation Index 4% (ODI4%) — 3.16; 7.61 events per hour — p=0.0134
Phase 2 N=22 Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRI
Epilepsy · SUDEP
Primary: Study Recruitment Rate — 3.8 participants/3 months
Phase 3 N=10 Validation of the AVAPS AE Algorithm in Chronic Obstructive Pulmonary Disease (COPD) Patients
COPD · OSA
Primary: Control of Nocturnal Hypoventilation — 6.5; 6.7 kPa
N/A N=22 Non-invasive Ventilation System in Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
Pulmonary Disease, Chronic Obstructive · Airflow Obstruction, Chronic · Chronic Obstructive Airway Disease
Primary: Device Tidal Volume — 180 mL
N/A N=8 Apnea Hypopnea Index Severity Versus Head Position During Sleep
Sleep Disordered Breathing · Sleep Hypopnea · Sleep Apnea
Primary: Number of Participants With Apnea Hypopnea Index (AHI) Severity Improvement — 8 Participants — p=<.05
N/A N=30 Safety of the Nocturnal Passy Muir Valve and Impact on Sleep Quality at an LTACH Setting
Tracheostomy
Primary: Heart Rate — 84.10; 84.33 beats per minute — p=0.87
N/A N=29 Predicting Successful Sleep Apnea Treatment With Acetazolamide in Heart Failure Patients
Heart Failures
Primary: The Severity of Sleep Disordered Breathing (Apnea-hypopnea Index, AHI) — 26.3; 36.1; 32.3; 44.6 events per hour
N/A N=90 AVAPS-AE Efficacy Study
Obesity Hypoventilation Syndrome
Primary: Daytime Partial Pressure of Carbon Dioxide in Arterial Blood (PaCO2) — 47.1; 51.8; 50.7; 40.7 mmHg
N/A N=21 Positive Airway Pressure for the Treatment of Asthma
Asthma · Sleep Apnea
Primary: Asthma Control Test — 19.3; 19.8; 19.1; 19.6 units on a scale — p=0.8
N/A N=47 Estimating Apnea Phenotypes From Polysomnography: Oxygen
Sleep Apnea
Primary: Apnea-hypopnea Index — 40.5; 57.9; 48.5; 74.3 events/hour — p=0.4
N/A N=21 Modified Adaptive Servoventilation (ASV) Compared to Conventional ASV
Periodic Breathing · Breathing-Related Sleep Disorder
Primary: Apnea/Hypopnea Index (AHI) — 3.9; 6.4 Events per hour — p=0.022
N/A N=40 Sleep Apnoea Breathing Record Exploratory Study (SABRES)
Sleep Apnea
Primary: Correlation Between the Trial Device and an Established Device — 0.955 correlation coefficient
Phase 4 N=20 The Impact of Venlafaxine on Apnea Hypopnea Index in Obstructive Sleep Apnea
Obstructive Sleep Apnea
Primary: The Apnea Hypopnea Index — 40.5; 46.1 Events per Hour of Sleep
N/A N=174 Comparison of Oxygenation and Ventilation With a Novel Nasal Mask Versus Standard of Care During Colonoscopy
Colonoscopy · Oxygenation · Ventilation
Primary: Time to First Intervention — 10; 19 minutes
N/A N=30 Sleep and Daytime Use of Humidified Nasal High-flow Oxygen in COPD Outpatients
Pulmonary Disease, Chronic Obstructive · Hypercapnia · Hypoxia
Primary: Use of Oxygen Therapy by HNHF-O2 at Home — 6.8 Hours
N/A N=2 Pilot Study of a Self-Supporting Nasopharyngeal Airway in Hypotonia
Sleep Apnea, Obstructive · Hypotonia · Child, Only
Primary: Ability to Tolerate Measured by Percent of Participants With Protocol Goal — 50 percent of participants