N/A N=369 Cessation in Non-Daily Smokers
Smoking
Primary: Smoking Cessation, Continuous 6-month Abstinence — 13; 10 Participants — p=0.46
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=238 Very-Low Nicotine Cigarettes and Non-Daily Smokers
Smoking
Primary: Change in Cigarette Consumption — -1.6; -0.05 cigarettes per day — p=<0.001
Phase 4 N=278 Informing Tobacco Treatment Guidelines for African American Non-Daily Smokers
Smoking Cessation
Primary: Smoking Abstinence — 21; 8 Participants
N/A N=213 Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers
Cigarette Smoking-Related Carcinoma · Tobacco-Related Carcinoma
Primary: Usual Brand Cigarettes Per Day — 15.803; 2.1563; 1.8353; 1.4931 Cigarettes per Day
Phase 3 N=216 Maintaining Nonsmoking
Nicotine Dependence
Primary: Number of Participants With Reported 7-day Point Prevalence Abstinence at Week 12 — 22; 20; 29; 20 Participants
N/A N=139 Cigarette Smoking Among Young Adults
Cigarette Smoking · Smoking Behaviors
Primary: Puff Topography — 1108; 1045.2; 1084.6 mL
N/A N=31 Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking
Smoking
Primary: Breath Sample (Expired Carbon Monoxide) — 18.77; 31.07; 25.38; 30.49 parts per million — p=0.92
Phase 4 N=93 Varenicline for Light Smokers
Smoking
Primary: Point Prevalence Smoking Outcome at 12 Weeks (End of Treatment) — 24; 7 participants — p=<0.001
N/A N=326 Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age
Tobacco Use Disorder
Primary: Number of Cigarettes Smoked Per Day — 22.54; 14.32; 11.76; 7.63 cigarettes per day
Early Phase 1 N=34 Nicotine Reinforcement and Aversion in Young Adult Light Smokers
Nicotine Addiction
Primary: DEQ - Pleasurable — 2.14; 2.05; 1.98; 2.37 score on a scale
N/A N=36 Palatability of Experimental Cigarettes - Study 2
Smoking
Primary: Change in UrineTotal Nicotine Equivalent (TNE) Between Baseline and Week 1 — -16.2; -7.6; 1.3 nmols/ml
Phase 2 N=326 Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder
Tobacco Use Disorder
Primary: Number of Cigarettes Smoked Per Day — 22.54; 14.32; 11.76; 7.63 cigarettes per day
Phase 2 N=326 Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders
Tobacco Use Disorder
Primary: Cigarettes Per Day — 22.54; 14.32; 11.76; 7.63 cigarettes per day
Phase 3 N=74 Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day
Tobacco Use Disorder
Primary: Feasibility as Indicated by Self-reported Adherence to Study Cigarettes. — 7.1; 7.3; 10.4; 13.3 Percent non-study cigarettes per day
N/A N=35 Low Nicotine Cigarettes, Smoking, and Chronic Pain
Chronic Pain · Smoking, Cigarette
Primary: Cigarettes Smoked Per Day — 14.5; 17.2; 16.4; 20.3 cigarettes/day — p=<.0001
Phase 2 N=45 Effects of Random Nicotine Delivery on Smoking Cessation
Smoking Cessation · Cigarette Smoking · Smoking (Tobacco) Addiction
Primary: Change in Number of Cigarettes Smoked Per Day (CPD) — -10.3; -9.0; -7.6 cigarettes per day — p=.55
Phase 2 N=30 The Effect of Naltrexone and Varenicline on Alcohol-Mediated Smoking Lapse
Smoking
Primary: Latency to Initiate Ad-lib Smoking Session — 28.134; 45.861; 21.737 minutes
Phase 2 N=209 Impact of Alternative Nicotine-Delivery Products on Combustible Cigarette Use
Nicotine Dependence
Primary: Mean Number of Conventional Cigarettes Smoked During Each Switch Week — 3.2; 3.2; 5.8; 3.1 Cigarettes per day
N/A N=100 Version 2 of the Smoking Cessation Smartphone App "Smiling Instead of Smoking" (SiS)
Smoking Cessation · Smoking, Tobacco
Primary: Ease-of-use and Helpfulness of the App — 2.39; 2.36; 2.42; 2.39 units on a scale
Phase 3 N=81 Nicotine Lozenge or Tobacco-Free Snuff for Smokeless Tobacco Reduction
Tobacco Dependence
Primary: Tobacco Abstinence at 12 Weeks — 8; 5 participants
Phase 2 N=232 UW Withdraw From Tobacco Study
Tobacco Dependence
Primary: Change in Total Score on Wisconsin Smoking Withdrawal Scale2 Long (WSWS2-L) — 2.64; 2.36; 2.29; 2.69 score on a scale
N/A N=136 Reduced Nicotine Content Cigarettes and Tobacco Switching Behaviors
Tobacco Addiction · Dual Tobacco Use
Primary: Number of Days Using Alternative Products — 14; 26; 20 Number of days
N/A N=150 Methods Project 4: Clinical Trial
Smoker
Primary: Smoke-free Days — 14.5; 0; 0 days
Phase 2 N=62 The Effect of Varenicline (Chantix) and Bupropion (Zyban) on Smoking Lapse Behavior
Smoking Lapse Behavior
Primary: Latency to Initiate Ad-lib Smoking Session — 38.138; 39.416; 19.249 minutes
N/A N=3,125 Nonsmokers Helping Smokers Quit
Smoking Cessation
Primary: Number of Participants Reporting 30-day Abstinence — 203; 222; 135 Participants
N/A N=33 Impact of Switching to Non-Menthol Cigarettes Among Smokers
Tobacco Use
Primary: Total Number of Cigarettes Smoked — 2.2 cigarettes per day
N/A N=34 Youth Smoking Cessation: Therapy +/- "The Patch"
Smoking
Primary: Acceptance of Nicotine Replacement Therapy — 26 participants
Phase 2 N=60 An Alternative Dosing Schedule of Varenicline for Smoking Cessation
Smoking Cessation
Primary: Change in Smoking Behavior — -6.3; -3.2 Change in Cigarettes Per Day
Phase 3 N=398 Smoking Cessation Versus Long-term Nicotine Replacement Among High-risk Smokers
Smoking · Pulmonary Disease, Chronic Obstructive · Tobacco Use Disorder
Primary: Smoking Abstinence (Point Prevalent) — 23; 24 Participants — p=0.88
N/A N=5 Effects of Smoking State on Decision Making
Behavior
Primary: Effort Based Decision Making — 29.5; 18.3 high effort selections