N/A N=90 AVAPS-AE Efficacy Study
Obesity Hypoventilation Syndrome
Primary: Daytime Partial Pressure of Carbon Dioxide in Arterial Blood (PaCO2) — 47.1; 51.8; 50.7; 40.7 mmHg
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=20 EPO2-PV: Evaluation of Pre-Oxygenation Conditions in Morbidly Obese Volunteer: Effect of Position and Ventilation Mode
Morbid Obesity · Bariatric Surgery Candidate
Primary: Functional Residual Capacity — 2573; 2145; 2456; 2219 ml
N/A N=23 Right Ventricular Hemodynamics Using Cardiac MRI in Patients COPD and OSA
Obstructive Sleep Apnea · Chronic Obstructive Pulmonary Disease · Overlap Syndrome
Primary: Right Ventricular Remodeling Index — 0.3747; 0.2817 ratio
N/A N=56 Use of Non-Invasive Positive Pressure Ventilation in Patients With Severe Obesity Undergoing Upper Endoscopy Procedures
Severe Obesity · Hypoxia
Primary: Percentage of Participants With an Oxygen Desaturation Event ≤ 94% — 57.1; 14.3 percentage of participants
N/A N=50 EPO2-A: Evaluation of Pre-Oxygenation in Morbid Obesity: Effect of Position and Positive Pressure Ventilation
Obesity, Morbid
Primary: Non Hypoxic Apnea Time — 216.7; 258.2 seconds — p=0.005
N/A N=45 Obesity, Sleep Apnea, and Insulin Resistance
Insulin Sensitivity · Obstructive Sleep Apnea
Primary: Change in Apnea-hypopnea Index (AHI) Outcome Measure in Response to Pioglitazone or Placebo — 35.8; 34.4 AHI events/hour
N/A N=181 The Effects of Obesity and Obstructive Sleep Apnea on Inflammation and Heart Disease
Sleep Apnea Syndromes · Inflammation
Primary: Inflammation — -11.47; -37.45; -32.66 percentage of change in crp at week 24
N/A N=104 Lifestyle Modification Program to Treat Obstructive Sleep Apnea Patients
Obstructive Sleep Apnea
Primary: Apnea-hypopnea Index (AHI) at One Year — 35.3; 39.6 events per hour
N/A N=108 Obstructive Sleep Apnea in Pregnancy
Sleep Apnea, Obstructive · Pregnancy · Obesity, Morbid
Primary: Number of Participants With a Negative Obstructive Sleep Apnea (OSA) Home Sleep Test Result — 61 Participants
N/A N=4,577 Incidence of Obstructive Sleep Apnea in Pregnancy
Obstructive Sleep Apnea · Pregnancy
Primary: Positive Berlin Questionnaire Indicative of Sleep Disordered Breathing — 1343; 96 participants — p=0.001
Phase 2 N=45 A Study of VI-0521 for the Treatment of Obstructive Sleep Apnea / Hypopnea Syndrome in Obese Adults
Sleep Apnea
Primary: Change in the Apnea/Hypopnea Index (AHI) Between Baseline and Week 28/Early Term. — -16.6; -31.46 events/hour — p=0.0084
N/A N=47 Bi-PAP vs Sham Bi-PAP on Pulmonary Function in Morbidly Obese Patients After Bariatric Surgery
Atelectasis · Pulmonary Infection · Chronic Obstructive Pulmonary Disease (COPD)
Primary: Forced Expiratory Volume at One Second (FEV1) Difference — 3.1; 3.1; 1.3; 1.4 Litres — p=0.88
Early Phase 1 N=63 Respiratory and Autonomic Plasticity Following Intermittent Hypoxia
Sleep Apnea Syndromes
Primary: Ventilation (Aim 1) — 1.19; 1.14; 1.35; 1.16 fraction of baseline — p=0.001
N/A N=63 High-Flow Nasal Cannula and Desaturation Episodes in the Morbidly Obese Patients
Desaturation of Blood · Obesity · Colonoscopy
Primary: The Number of Desaturation Episodes — 0; 0 Episodes
N/A N=29 Effects of CPAP on Diet, Physical Activity, and Cardiovascular Risk
Sleep Apnea Syndromes
Primary: Fat Mass (% of Total Body Mass) — 40.0; 37.7; 38.7; 38.6 percentage of total body mass
Phase 2 N=49 Apnea, Bariatric Surgery Versus Continuous Positive Airway Pressure (CPAP) Trial
Obstructive Sleep Apnea · Obesity
Primary: Effective Apnea Hypopnea Index — 29.5; 20.0 Events per hour
N/A N=17 Lifestyle Program for Obstructive Sleep Apnea With Severe Obesity
Obstructive Sleep Apnea · Obesity
Primary: Ability to Use the Devices at Home — 15 Participants
N/A N=25 Servo-Ventilation In-lab PSG Evaluation
Sleep Apnea Syndromes
Primary: Average Apnea Hypopnea Index Among Different Polysomnography Devices. — 18.4; 25.4; 24.1; 19.2 events per hour
N/A N=9 Long QT Syndrome and Sleep Apnea
Long QT Syndrome · Sleep Apnea
Primary: QT Interval (Corrected) Baseline Visit — 453.4 square root of seconds — p=0.73
N/A N=34 Positive Airway Pressure Program
Sleep Apnea, Obstructive
Primary: Participant Providing Feedback — 26 Participants
N/A N=50 The Effect of Prolonged Inspiratory Time on Pulmonary Mechanics in Obese Patients
Hypoxia
Primary: PaO2(Partial Pressure of Oxygen in Arterial Blood) — 178.71; 198.04; 185.25; 202.54 mmHg
N/A N=240 The Effects of Treating Obese and Lean Patients With Sleep Apnea
Sleep Apnea · Obesity
Primary: Change From Baseline in Mean Arterial Blood Pressure — -4.21; -0.95 mm Hg
N/A N=25 The Role of Oxidative Stress in the Cardiovascular Consequences of Sleep Apnea
Sleep Apnea
Primary: Flow Mediated Dilation — 5.7; 9.5; 7.3 percentage change of vessel diamter — p=0.02
Phase 2 N=13 DAW1033B2 in Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA)
Primary: Apnea Hypopnea Index (AHI, Events/Hour of Sleep) — 33; 20.4 events/hour of sleep — p=0.47
N/A N=17 Etiology of Sleep Apnea-related Hyperaldosteronism - BP Treatment
Obstructive Sleep Apnea · Resistant Hypertension · Hyperaldosteronism
Primary: Severity of Obstructive Sleep Apnea — -18.3; 7.0 events/hour
N/A N=22 Non-invasive Ventilation System in Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
Pulmonary Disease, Chronic Obstructive · Airflow Obstruction, Chronic · Chronic Obstructive Airway Disease
Primary: Device Tidal Volume — 180 mL
N/A N=100 Oxygen Saturation Patterns in Post-Op Patients at Risk for Obstructive Sleep Apnea
Obstructive Sleep Apnea
Primary: Presence of Repetitive Reductions in Nasal Airflow Patterns in the Pulse Oximetry Saturation Trend Data. — 30 participants
N/A N=184 Hyperglycemic Profiles in Obstructive Sleep Apnea: Effects of PAP Therapy
Sleep Apnea · Diabetes
Primary: Change in Continuous Glucose Monitoring System Standard Deviation — 0.8; 1.1 mg/dL
N/A N=83 The Effects of Obstructive Sleep Apnea and Its Intervention on Coronary Heart Disease
Hypertension · Metabolic Disorder
Primary: Change of Daytime Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) Pre-treatment and Post-treatment — -8; -3; -4; -3 mm Hg — p=<0.05
N/A N=696 Pragmatic Obstructive Sleep Apnea Weight Loss Trial Assessing Effectiveness and Reach
Obesity · Sleep Apnea, Obstructive
Primary: Change in Sleep-related Quality of Life — 1.43; 0.93 units on a scale — p=0.001