N/A N=32 Induced Gingivitis & Intra-oral Imaging
Plaque Induced Gingivitis
Primary: Change From Baseline Gingivitis at Day 14 as Measured by Non-invasive Microimaging and Gingival Index. — 0.6; 0.15 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=5,117 Periodontal Disease Prevention Study
Periodontitis
Primary: Percentage of Participants With Tooth Loss Over 16 Year Period — 16.4; 13.8; 22.1; 16.9 percentage of participants
Phase 2 N=108 Effects of Probiotics on Oral Health
Periodontal Health · Dental Plaque Accumulation
Primary: Gingival Health — 0.46; 0.18 units on a scale — p=0.015
N/A N=48 Gingival Bleeding and Von Willebrand Disease Typ 2 and 3
Gingival Bleeding · Von Willebrand Diseases
Primary: Bleeding on Probing (BOP) — 14.5; 12.3 percentage of sites
Phase 3 N=983 Prevention of Adult Caries Study (PACS)
Caries, Dental
Primary: Total Net D12FS Caries Increment (Total of Non-cavitated Lesions (D1), Cavitated Lesions (D2) and Sound Surfaces (S)) — 2.43; 2.68 weighted increment units/13 months…
N/A N=180 Oral Health Literacy and Oral Education
Retention
Primary: Changes in the Knowledge Score — 4.81; 4.86; 4.64; 7.10 units on a scale — p=<0.001
Phase 2 N=175 Effect of Improved Oral Hygiene to Prevent Pneumonia in Hospitalized Patients
Pneumonia
Primary: Colonization of the Oral Cavity by Respiratory Pathogens (on Teeth/Denture/Buccal Mucosa) as Determined by Quantitative Cultures Expressed as Colony Forming Units (Cfu)…
N/A N=414 Oral Hygiene in Assisted Living
Aging · Long-Term Care
Primary: Plaque Index Score for Long-Term Care (PI-LTC) - Baseline-Aim2 — 1.6; 1.6 score on a scale — p=0.77
N/A N=288 Oral Health Educational Methods in Adolescence
Adolescent Behavior
Primary: Knowledge Score — 11; 13; 11; 13 score on a scale — p=0.001
Phase 4 N=155 Baseline Oral Health Study: UnCoVer the Connections to General Health
Cardiovascular Diseases · Diabetes Type 2
Primary: Impact of Treatment on Change in Oral Health Measures — 0.186; 0.190 millimeters (probing depth difference) — p=0.957
N/A N=180 Oral Health Education Interventions Among Seniors
Quality of Life · Self Efficacy · Knowledge
Primary: Change in Oral Health Related Quality of Life (OHIP-14; Slade, 1997) — 16.8; 12.4; 10.5 score on a scale — p=.000
Phase 4 N=49 Compare Anti-inflammatory Dentifrices
Gingivitis
Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05
N/A N=10,069 Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi
Preterm Birth · Periodontal Disease · Caries, Dental
Primary: Rate of Preterm Birth — 878; 549 Participants — p=<0.05
N/A N=746 Oral Hygiene and Maternity Outcomes Multicenter Study (OHMOM)
Gingivitis · Pregnancy
Primary: Change From Baseline in Löe-Silness Gingivitis Index — 0.141; 0.154 score on a scale
N/A N=96 Oral Tissue Tolerance of a Mouthrinse
Dental Health
Primary: Change in Tooth Color as Represented by ΔE at 8 Weeks Post Baseline From the CIElab Assessment — 0.909; 1.035 units on a scale — p=0.168
N/A N=61 Trial of Toothpaste to Reduce Plaque and Inflammation
Plaque · Inflammation
Primary: Change in Oral Plaque — -1.05; -0.03 log(percentage) — p=0.001
Phase 1 N=20 Fluoride Retention in the Mouth of Older Adults
Hyposalivation
Primary: Fluoride Concentration in Dental Biofilm Fluid at Baseline — 0.24; 0.22 parts per million (ppm) of fluoride — p=0.8412
N/A N=51 Oral Pathology Asynchronous Telementoring Pilot Study
Oral Cancer
Primary: Percentage of Dental Patients Who Strongly Agreed or Agreed That the Use of an Intra-Oral Camera By Their Dentists Helped Them to Better Understand Oral Cancer Screening…
N/A N=718 Promoting Oral Health Among Smokers Randomized Trial
Oral Disease · Smoking
Primary: 7 Day Point Prevalent Abstinence (PPA) — 109; 121 Participants — p=0.13
N/A N=60 Care Partner Assisted Intervention to Improve Oral Health of Individuals With Mild Dementia
Mild Dementia
Primary: Plaque Index — 0.55; 0.41; 0.48 Proportion of sites with plaque deposits — p=0.939
N/A N=18 Role of Infected Blood Dendritic Cells in Heart Disease Risk
Chronic Periodontitis
Primary: Frequency of Blood Dendritic Cells From Baseline — 12; 14 % MFI
N/A N=53 Use of Two Dissolvable Therapeutics Under Removable Partial Dentures
Edentulous Jaw · Edentulous Mouth
Primary: Change From Baseline in Patient Comfort for as Assessed by Numerical Scale. — 0.99; 1.16 units on a scale
Phase 1 N=48 The Effect of Palatal Brushing on Denture Stomatitis
Denture Stomatitis
Primary: Palatal Inflammation — 3; 3; 2.5; 2 units on a scale — p=<0.0001
Phase 4 N=113 Relationship of Periodontal Disease Treatment and Type 2 Diabetes Mellitus in the Gullah Population
Periodontal Disease · Type 2 Diabetes Mellitus
Primary: Glycated Hemoglobin A1c — 8; 8.2 percentage of Glycated Hemoglobin A1c
N/A N=12 Dental Office Prevention Strategies for Children
Dental Plaque
Primary: Dental Plaque Levels Measures on Scale of 0-2 — 0.391 units on a scale
N/A N=60 The Effect of a Home-based Orofacial Exercise Program on Oral Aperture of Systemic Sclerosis Patients
Microstomia · Systemic Sclerosis
Primary: Change From Baseline in Oral Aperture Measurement — 32.98; 32.92; 33.40; 34.37 milimeters — p=0.564
Phase 2 N=38 Short-term Effect of 2% Atorvastatin Dentifrice in Periodontal Status.
Chronic Periodontitis
Primary: Change in Periodontal Inflammation Surface Area (PISA) — 638.16; 288.72 square millimeters
Phase 4 N=57 The Efficacy of Stabilized Chlorine Dioxide Rinse as a Chemical Adjuvant for Treatment of Per-implant Mucositis
Peri-implant Mucositis
Primary: Global Probing Depth — 2.37; 2.64 mm — p=0.28
N/A N=66 Chlorhexidine Gluconate Oral Care for Adults Experiencing Trauma
Ventilator Associated Pneumonia
Primary: Effectiveness of Chlorhexidine Gluconate Oral Care for Trauma Patients — 30; 29 participants
N/A N=60 Activated MMP-8 as Diagnostic Test for Periodontitis
Generalized Chronic Periodontitis
Primary: Percentage of True Positive/Negative aMMP-8 Tests of All Periodontitis Patients (Sensitivity/Specificity) — 87; 60 percentage of true cases (sens./spec.)