N/A N=22 Bad Breath Response to Tongue Scraper and Rinses
Halitosis
Primary: Percentage of Participants With Rosenberg Score at Indicated Time Points — 96; 74; 79; 100 percentage of participants — p=<0.001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=99 Controlling Oral Malodor by ClōSYS Oral Rinse
Oral Malodor
Primary: Reduction in Malodor as Measured by Organoleptic Score — 3.58; 3.60; 3.63; 3.65 score on a scale — p=<0.00001
N/A N=100 Controlling Oral Malodor by ClōSYS® Oral Rinse
Oral Malodor
Primary: Change in Malodor as Measured by Organoleptic Score — 3.09; 3.08; 3.03; 3.23 score on a scale — p=<0.010
N/A N=125 Microbial Basis of Systemic Malodor and "People Allergic To Me" Conditions
Nutritional and Metabolic Diseases
Primary: Gut Microbiome — 52; 64; 25; 33 Normalized OTU counts
Phase 2 N=45 Effect of Miswak and Miswak Extract on Oral Malodor
Oral Malodor · Halitosis
Primary: Organoleptic Scores After the First Use of the Prescribed Method by 15 Minutes (Masking Effect), and After 7 Days of Use (Therapeutic Effect). — 2.10; 1.62; 1.36; 1.10…
N/A N=16 Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
Nutritional and Metabolic Diseases
Primary: Number of Test Results Outside the Normal Range — 6; 3; 0; 0 participants
N/A N=39 Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Nutritional and Metabolic Diseases
Primary: Differences in Metabolite Concentrations in Urine Between Individuals With Malodor Issues and Age-matched Healthy Controls. — 3.4; 8.6; 0.443; 0.8 uMol/mM creatinine
N/A N=104 A Clinical Study to Examine the Effects of an Experimental Toothpaste Compared to a Regular Fluoride Toothpaste on Breath Odor in a Population With Gingivitis
Halitosis
Primary: Adjusted Mean Change From Baseline (Day 0, Pre-Brushing) to Week 3 (Pre-Brushing) in Breath Organoleptic Scores — -1.23; 0.07 Score on a scale — p=<0.0001
Phase 2 N=45 Inulin and S. Salivarius Reduce Halitosis
Halitosis · Tongue Diseases
Primary: Halitosis Measured by Organoleptic Test — 3.2; 3.2; 2.9; 1.4 score on a scale
N/A N=80 SmartMouth Advanced Clinical Formula Clinical Research Design Protocol
Gingivitis · Periodontitis
Primary: Gingival Index — -0.22; -0.34; -0.19 units on a scale
Phase 4 N=128 Clinical Investigation to Examine Toothpaste Effect on Oral Bacteria
Oral Bacteria Levels in the Mouth
Primary: Anaerobic Bacteria — 8.40; 8.42; 8.43 colony forming units — p=>0.05
N/A N=746 Oral Hygiene and Maternity Outcomes Multicenter Study (OHMOM)
Gingivitis · Pregnancy
Primary: Change From Baseline in Löe-Silness Gingivitis Index — 0.141; 0.154 score on a scale
Phase 3 N=21 An Open, Uncontrolled Study of GK567 in the Deodorization of Malodorous Fungating Neoplastic Tumours
Malodorous Infected Cutaneous Ulcer
Primary: The Success Rate — 95.2 percentage of participants
Phase 3 N=48 Reducing Bacteria That Cause Tooth Decay
Caries, Dental · Cariostatic Agents
Primary: Microbial Levels — 11; 7; 15; 15 Participants — p=0.35
Phase 2 N=175 Effect of Improved Oral Hygiene to Prevent Pneumonia in Hospitalized Patients
Pneumonia
Primary: Colonization of the Oral Cavity by Respiratory Pathogens (on Teeth/Denture/Buccal Mucosa) as Determined by Quantitative Cultures Expressed as Colony Forming Units (Cfu)…
N/A N=96 Oral Tissue Tolerance of a Mouthrinse
Dental Health
Primary: Change in Tooth Color as Represented by ΔE at 8 Weeks Post Baseline From the CIElab Assessment — 0.909; 1.035 units on a scale — p=0.168
N/A N=31 Oral and Dermal Tolerability Clinical Study of an Experimental Denture Wipe
Denture Cleansers
Primary: Proportion of Participants Experiencing or Reporting Treatment Emergent (TE) Oral Adverse Events (AEs) on or Before 14 Days of Use — 0.039; 0.013 Proportion of…
N/A N=414 Oral Hygiene in Assisted Living
Aging · Long-Term Care
Primary: Plaque Index Score for Long-Term Care (PI-LTC) - Baseline-Aim2 — 1.6; 1.6 score on a scale — p=0.77
Phase 1 N=20 Fluoride Retention in the Mouth of Older Adults
Hyposalivation
Primary: Fluoride Concentration in Dental Biofilm Fluid at Baseline — 0.24; 0.22 parts per million (ppm) of fluoride — p=0.8412
Phase 2 N=44 The Effect of Chlorhexidine on the Oral and Lung Microbiota in Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease
Primary: Change in Sputum Bacteria Biomass — -0.24; -0.14 log10 molecules/uL/mL
N/A N=230 Efficacy of Oral Rinses for Inactivation of COVID-19 (MOR2)
COVID-19 · Coronavirus Infection · SARS CoV 2 Infection
Primary: Change in Quantitative Polymerase Chain Reaction (qPCR) From Baseline to 30 Minutes — 0.0345; -0.5577; -1.4789; 0.2339 natural log copies/20μL sample — p=0.59
N/A N=39 Clinical Evaluation of Oral Rinse for Xerostomia
Xerostomia
Primary: Change in Dry Mouth Symptom by Visual Analog Scale at 14 Days From Baseline — 10.1; 11.6; 13.0 mm
Phase 3 N=185 Drug-induced Xerostomia. Evaluation of Malic Acid 1%, Salivary Mucins and Buffering Capacity
Xerostomia · Depression · Hypertension
Primary: Dry Mouth Questionnaire (DMQ) — 3.4; 1.4 units on a scale
N/A N=55 Consumer Perception of an Experimental Mouthwash After a Single Use in Dry Mouth Subjects
Xerostomia
Primary: Number of Participants With Response to Post-Product Use Questionnaires 1 (PPUQ 1); Question No.1 — 1; 1; 5; 0 Participants
Phase 3 N=24 Investigate Oral Bacteria in Adult Population
Oral Bacteria
Primary: Antimicrobial Species in Plaque(Actinomyces) — 0.023; 0.3881; 0.0538 log CFU (Colony forming units) — p=0.05
N/A N=53 Use of Two Dissolvable Therapeutics Under Removable Partial Dentures
Edentulous Jaw · Edentulous Mouth
Primary: Change From Baseline in Patient Comfort for as Assessed by Numerical Scale. — 0.99; 1.16 units on a scale
N/A N=718 Promoting Oral Health Among Smokers Randomized Trial
Oral Disease · Smoking
Primary: 7 Day Point Prevalent Abstinence (PPA) — 109; 121 Participants — p=0.13
Phase 1 N=100 Oral Mucosal Effects In Adult Smokers Associated With Two Nicotine Lozenge Formulations
Safety Issues
Primary: OMI-20 Total Score Change From Baseline to Day 3 — 0.0; 0.0 score on a scale
Phase 4 N=57 The Efficacy of Stabilized Chlorine Dioxide Rinse as a Chemical Adjuvant for Treatment of Per-implant Mucositis
Peri-implant Mucositis
Primary: Global Probing Depth — 2.37; 2.64 mm — p=0.28
Phase 3 N=73 Clinical Research Study Efficacy of a Prototype Oral Rinse
Dental Plaque
Primary: Gingival Index — 1.90; 1.84 Units on a scale — p=0.005