Phase 2 N=66 Oxytocin for Couples Conflict Resolution
Substance Misuse · Interpersonal Conflict · Neuroendocrine Reactivity
Primary: Change in Frequency of Distress Maintaining Attributions — .81; -.48 distress maintaining attributions
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 1 N=21 Brain Dynamics of Oxytocin
Brain Dynamics in Healthy Adults
Primary: Number of Benevolent Rounds — 6.8; 6.8 number of rounds
N/A N=112 Oxytocin in Cocaine Dependence
Cocaine Dependence
Primary: Subjective Stress Response TSST — 5.33; 5.28; 2.05; 2.13 units on a scale
Phase 4 N=20 The Effect of Intranasal Oxytocin on Pain Sensitivity and Threshold
Healthy
Primary: Hot and Cold Thermal Sensory Threshold for Pain at Baseline in Degrees Celsius. — 43.93; 43.0; 14.81; 13.33 degrees Celsius — p=.47
Phase 2 N=109 Inhaled Oxytocin and HPA Axis Reactivity
Depression, Postpartum · Anxiety Disorders · Stress, Psychological
Primary: Mean Cortisol (CRT) During Trier Social Stress Test (TSST) — 19.17; 16.87; 15.71; 13.89 pg/mL — p=0.37
Phase 2 N=20 Peripheral Oxytocin and Touch
Healthy Adults
Primary: Change in Mean Pleasantness Rating of Gentle Brushing — -8.7; -14.1 score on a scale
Phase 2 N=41 Oxytocin Administration in BDD and OCD
Body Dysmorphic Disorder · Obsessive-compulsive Disorder
Primary: Emotion Recognition Questionnaire — 18.67; 17.00; 17.00; 16.40 score on a scale
Phase 4 N=25 Intranasal Oxytocin for the Treatment of Pain Associated With Interstitial Cystitis
Interstitial Cystitis
Primary: Change From Baseline Measured as Global Response Assessment (GRA) Score at 6 and 24 Hours — .5; -.1 units on a scale — p=0.688
Phase 4 N=140 Oxytocin Dosage to Decrease Induction Duration
Obesity · Labor, Induced · Oxytocin
Primary: Length of Time to Delivery — 796; 694; 715; 762 minutes
Phase 2 N=11 Oxytocin and Affect Processing in Posttraumatic Stress Disorder
Posttraumatic Stress Disorder (PTSD)
Primary: fMRI Analysis: Change in Anterior Insula Region — -12.6; -1.6; 10.6; -7.8 percentage of area activation
N/A N=60 The Effect of Oxytocin on Fear Memory Consolidation Novel Intervention to Prevent Posttraumatic Stress Disorder (PTSD)
Posttraumatic Stress Disorder
Primary: Differential Skin Conductance Response (SCR) During the First Two Extinction Trials — 0.15; 0.00 micro-Siemens (square rooted) — p=0.28
Phase 2 N=63 Oxytocin Suppresses Substance Use Disorders Associated With Chronic Stress
Alcohol Use Disorder · Stress Disorders, Post-Traumatic · Anxiety Disorders
Primary: Change in Craving to Use Alcohol Rating (Visual Analog Scale) — 0.076; -0.928 score on a scale
Phase 2 N=9 Oxytocin Treatment of Alcohol Dependence
Alcohol Withdrawal · Alcohol Dependence
Primary: Change in Clinical Institute Withdrawal Assessment for Alcohol (CIWA) Score — -2.76; 1.01 units on a scale
Phase 2 N=12 Oxytocin Treatment of Opioid Dependence
Opioid Dependence · Opioid Withdrawal
Primary: Area Under the Curve (AUC) in COWS Total Score on Days 1 to 5 Inclusive — 4.2; 3.4 Average COWS score * hours
N/A N=106 Oxytocin's Effect on Socioemotional Aging
Aging
Primary: Extent of Trust Behavior — 39.03; 44.42; 45.11; 46.06 monetary units
N/A N=74 Intranasal Oxytocin and Maternal Neglect
Maternal Behavior
Primary: Differences in Brain Activation (Blood Oxygen Level Dependent [BOLD] Signal) of Dopamine Reward Regions and Prefrontal Cortex After Intranasal Oxytocin Administration in…
Phase 2 N=33 Effect of Oxytocin on Stress Response in Cocaine-dependent Individuals
Cocaine Dependence
Primary: Salivary Cortisol Levels — 0.18; 0.22 mg/dl
N/A N=166 Effects of Oxytocin on Bleeding Outcomes During Dilation and Evacuation
Abortion · Dilation and Evacuation · Hemorrhage
Primary: Rate at Which Providers Intervene to Control Blood Loss During D&E Procedures. — 13; 6 Participants
Phase 4 N=22 Effects of Intramuscular (IM) Oxytocin on Pupil Diameter and Heart Rate Variability (HRV)
Chronic Pain Due to Injury
Primary: Fluctuation in Pupil Diameter (Hippus) -Pre Drug Administration — 1.61; 1.71 milliseconds^2 — p=0.64
Phase 4 N=18 Effects of Oxytocin on Behavior and Physiology in a Psychotherapy Setting
Behavior · Anxiety
Primary: Verbal and Nonverbal Behavior in Therapy Session: Effects of Drug — 34; 34.8; 45.4; 46.0 Number of behaviors exhibited
Phase 2 N=11 Oxytocin and Stress Response in Alcohol Use Disorder
Alcohol Use Disorder
Primary: Corticolimbic Functional Connectivity Based on fMRI Blood Oxygenation Level Dependent (BOLD) Response During the Stress Versus Neutral Conditions of the Montreal Imaging…
Phase 4 N=40 Neural and Behavioral Effects of Oxytocin in Autism Spectrum Disorders
Autism Spectrum Disorders
Primary: Change From Baseline in Brain Activity During Task (Task-based fMRI) After a Single Dose of Nasal Spray — 0.11; -0.26; -0.15; -0.16 Change-from-baseline (BOLD response)
Phase 2 N=42 Preventing Postpartum Depression With Intranasal Oxytocin
Depression, Postpartum · Anxiety
Primary: Treatment Effect on Mother-infant Bonding — 99.33; 99.35; 101.11; 97.90 score on a scale — p=0.5
Phase 4 N=1,003 Comparison of Low-dose and High-dose Oxytocin Regimens for Labor Augmentation
Dystocia
Primary: Number of Participants Delivered by Cesarean — 73; 72 Participants
Phase 3 N=51 Oxytocin Infusions and Blood Loss in Patients Undergoing Elective Cesarean Delivery.
Postpartum Hemorrhage
Primary: Total Estimated Blood Loss — 512; 634 ml
Phase 2 N=61 The Effects of Oxytocin in Obese Adults
Obesity
Primary: Mean Difference in Weight Loss Between Oxytocin and Placebo 8 Weeks After Baseline — 0.20; 0.26 kilogram
Early Phase 1 N=26 Intranasal Oxytocin Administration and the Neural Correlates of Social and Non-Social Visual Perception
Social Perception
Primary: Amplitude Social — -3.72; -3.55; -3.28; -3.30 microvolts — p=.003
Early Phase 1 N=12 Oxytocin Effects on Cardiac Electrophysiology
Cardiac Arrhythmia
Primary: Change in Electrophysiology Measure of AH Interval — 12.7; -1.5 milliseconds
Phase 2 N=290 Study of Oxytocin in Autism to Improve Reciprocal Social Behaviors
Autism Spectrum Disorders
Primary: Change in Aberrant Behavior Checklist-Modified Social Withdrawal Subscale ABC-mSW, a Measure of Social Reciprocity — 8.81; 8.68; 8.97; 8.68 score on a scale — p=0.503
Phase 2 N=17 Prolonged Exposure and Oxytocin
PTSD
Primary: PTSD Symptom Severity — 13.00; 17.71 scores on a scale