N/A N=20 Susceptibility of Cardiorespiratory Responses to Ozone During Cycling Exercise
Ozone Exposure During Rest and Exercise
Primary: Time-to-exhaustion on Maximal Cycling Bout — 209; 235 seconds — p=0.092
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=62 Air Pollution Study: The Effect of Ozone on the Lung
Air Pollution
Primary: Concentrations of M1 and M2 Macrophages in the Sputum 24 Hours After Exposure. — 6.823; 1.367 ratio of M2 to M1 macrophages
N/A N=15 Human Biological Responses to Low Level Ozone
Environmental Exposure · Nasal Inflammation
Primary: Change in % Polymorphonuclear Leukocytes (PMN) in Nasal Lavage Fluid Immediately Post-Exposure From Baseline — -1.02; -6.8 percent PMNs in nasal lavage fluid
Phase 4 N=18 Salbutamol Use in Ozone Air Pollution by People With Asthma and/or Exercise Induced Bronchoconstriction (EIB)
Asthma and/or Exercise Induced Bronchoconstriction · Ozone Air Pollution
Primary: Measured Before and 30 Minutes After Exercise in Each 1 Day Condition — 6.98; 5.96; -1.38; -.35 litres
Phase 2 N=18 Effect of Gamma Tocopherol Enriched Supplementation on Response to Inhaled O3 Exposure
Allergic Asthma
Primary: Change From Baseline in Sputum Percent Neutrophils (%PMN) Following Ozone Exposure — 34.1; 36.5 percent neutrophils
N/A N=25 Genetic Susceptibility to Ozone in Mild Asthmatic Volunteers
Mild Asthma
Primary: Post Ozone Change in Lung Function (FEV1) Between Subjects With GSTM1 Null Genotype Compared to GSTM1 Sufficient Subjects — 85; 79 percentage of FEV1 predicted
N/A N=94 Gas Exchange Kinetics and Work Load During Exercise
Methods of Exercise in Children
Primary: Maximum Oxygen Uptake (VO2) Measurements During Exercise — 1.6; 2.8; 3.2; 1.7 L/min
N/A N=20 Comparing Nose & Mouth Breathing During Exercise
Healthy
Primary: Blood Pressure During Exercise Between Study Arms — 142; 146 mmHg
N/A N=12 Effect of Exercise in OI
Orthostatic Intolerance · Postural Tachycardia Syndrome
Primary: Maximal Oxygen Consumption Capacity (VO2 Max) — 27.6; 24.5 mL/kg/min
Phase 4 N=11 Effect of an H1 Receptor Antagonist on Exercise Performance in Hypoxia
Hypoxia, Altitude
Primary: Performance Time — 17.03; 18.08; 16.32 minutes — p=0.047
N/A N=12 High-Intensity Interval Training to Improve Symptoms of Deployment-Related Respiratory Disease
Occupational Exposure
Primary: Maximum Oxygen Consumption (VO2max) — 26.4 ml/kg/min
N/A N=28 Exercise, Oxidative Stress and HIV
HIV Infections
Primary: Total Glutathione — 1,964; 3,490; 1,865; 3,995 nmoles glutathione/ ml of sample — p=<0.05
N/A N=45 Effect of Whole Body Periodic Acceleration on Airway Endothelial Function
Healthy · Smokers · Asthma
Primary: Airway Blood Flow Response to Albuterol — 2.85; -1.43; 17.93; 4.03 μl/min/ml
Phase 2 N=12 Evaluation of the Attenuation by Aes-103 of Hypoxia Mediated Decrements in Endurance Exercise Performance
Hypoxia
Primary: Primary Objective Endurance Exercise Performance — 22.4; 24.5; 24.0; 24.6 minutes
N/A N=75 Understanding the Exercise-Hypertension Paradox
Hypertension
Primary: Blood Pressure — 103; 106; 94; 101 mmHg
N/A N=50 Effects of Deployment Exposures on Cardiopulmonary and Autonomic Function
Abnormality, Respiratory System · Autonomic Nervous System
Primary: FEV1 — 0.94; 1.08; 0.95; 1.09 percentage of predicted normal values
Phase 2 N=64 Cystic Fibrosis and Endothelial Function: At Rest and During Exercise
Cystic Fibrosis
Primary: Percentage Flow-Mediated Dilation (FMD) — 5.64; 5.32; 6.29; 7.21 percentage of change in FMD
N/A N=10 "Facemask Use During High-intensity Interval Exercise in Temperate and Hot Environments"
Hypoxemia · Physiological Stress
Primary: Average Heart Rate Over the Course of High-intensity Interval Exercise — 144; 143; 148; 149 beats per minute — p=0.003
N/A N=10 Circadian Rhythm Disruption Effects on Smoke Inhalation
Inflammation · Sleep Deprivation · Circadian Rhythm Sleep Disorder, Shift Work Type
Primary: Blood Inflammation — 0.69; 0.79; 2.33; 1.63 pg/mL — p=<0.05
N/A N=60 Health Effects of Diesel Exhaust in Asthmatic Patients: A Real-world Study in a London Street
Asthma
Primary: Spirometry, Percentage Change in FEV1 From Baseline — -1.0; -4.8; -2.2; -7.4 percentage change in FEV1 from baseline — p=<0.05
Phase 3 N=28 Drug Combination on Exercise Performance at High Altitude
Acute Mountain Sickness
Primary: Time (Minutes) to Complete 2 Miles on a Treadmill — 1544; 1540 seconds
Phase 2 N=41 Rapid Acclimatization to Hypoxia at Altitude
Physiological Function in Low Oxygen Environment
Primary: Magnitude of Decrement in Exercise Time Trial Performance in Hypoxia (Low Oxygen) Compared With Normoxia (Normal Oxygen). — 22.3; 25.2; 22.2; 24.0 minutes
Phase 4 N=20 Effect of Bronchodilation on Cycle vs Treadmill Exercise Endurance Time in COPD
Chronic Obstructive Pulmonary Disease
Primary: Exercise Endurance Time — 490; 333; 472; 362 seconds — p=< 0.05
Phase 4 N=20 Effectiveness of Ipratropium Bromide in Preventing Exercise-induced Bronchoconstriction in Athletes
Bronchospasm, Exercise-Induced
Primary: Spirometry and Specific Airway Conductance Measured by Body Plethysmography Before and After Exercise Challenge After Randomized Administration of Either Inhaled…
Phase 4 N=8 Impact of Erythropoietin on Hematological Adaptations and Physical Performance
Exercise-Induced Anemia · Physical Performance
Primary: Concentration of Hemoglobin — 1.46 g/dL
N/A N=86 Pulmonary Function After Hyperbaric Oxygen Therapy
Oxygen Toxicity
Primary: Change in Percentage Predicted Forced Expiratory Volume in One Second (FEV1%) — 88.0; 85.9; 87.4; 84.6 Percentage of FEV1
Phase 4 N=8 Effects of Pioglitazone on Exogenous Carbohydrate Oxidation During Steady-State Exercise at High Altitude
High Altitude
Primary: Rate of Exogenous Glucose Oxidation — 0.31; 0.32 g/min
N/A N=212 Intrapartum Maternal Oxygen Supplementation: Effects on the Mother and Neonate
Intrauterine Resuscitation
Primary: Umbilical Artery Malondialdehyde — 9.8; 10.2 umol/L
Phase 4 N=12 The Influence of Menthol Gel During Exercise With Heat
Acute Exercise · Heat Exposure
Primary: Skin Blood Flow — 131.6; 119.2 arbitrary units — p=0.742
N/A N=93 Effect of Switching From Cigarette Smoking to IQOS on Exercise Capacity
Smoking · Exercise Capacity
Primary: Maximal Oxygen Uptake (VO2max, Absolute Values) — 1878; 2027; 2197; 1950 mL/min