Phase 2 N=119 Integrated Alcohol Disorder and PTSD Treatment
PTSD · Alcoholism
Primary: Clinician Administered PTSD Scale (CAPS) — 43.2; 42.1; 25.8; 32.9 score on a scale — p=.002
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=100 Topiramate and Prolonged Exposure
PTSD and Alcohol Use Disorder
Primary: CAPS-5 Change — 36.720; 38.600; 21.006; 29.872 score on a scale
Phase 1 N=12 Couple-Based Treatment for Alcohol Use Disorders and Post-Traumatic Stress Disorder
Alcohol-related Disorders · Post-traumatic Stress Disorder
Primary: Clinician-administered PTSD Scale (CAPS) — 58.89; 40.22 units on a scale — p=.028
N/A N=81 Integrated Treatment of OEF/OIF Veterans With PTSD & Substance Use Disorders
Posttraumatic Stress Disorders · Combat Disorders · Alcohol Dependence
Primary: Change in Post-traumatic Stress Disorder Symptomatology — -51.2; -35.9; -22.3; -10.9 score on a scale
N/A N=80 Reducing Alcohol Use & Post-traumatic Stress Disorder (PTSD) With Cognitive Restructuring & Experiential Acceptance
Alcoholism · Stress Disorders, Post-Traumatic
Primary: Average Drinks Per Day Assessed Using Daily Interactive Voice Response (IVR) — 3.6; 1.8; 3.1 drinks per day
Phase 2 N=69 Combined Treatment for Alcohol-Dependent Individuals With PTSD
Stress Disorders, Post-Traumatic · Alcohol Abuse · Substance-Related Disorders
Primary: Heavy Drinking Days/Week — 3.13; 2.89; 1.05; 0.48 Days/Week — p=0.34
N/A N=129 Cognitive Behavioral Therapy (CBT) for PTSD in Veterans With Co-Occurring SUDs
PTSD · Substance Use Disorders
Primary: CAPS Total Score Analysis Among Participants Completing at Least One Follow-up Assessment. — 77.2; 78.0; 67.5; 71.0 score on scale — p=.48
Phase 4 N=49 Serotonin Selective Reuptake Inhibitor Treatment of Dual Diagnosis Post-traumatic Stress Disorder and Alcohol Problems
PTSD · Alcohol Use Disorder
Primary: Percent Heavy Drinking Days — 55.5; 65.1 percentage of days
Phase 2 N=90 NAC for Treating Comorbid PTSD and SUD
Posttraumatic Stress Disorder (PTSD) · Alcohol Use Disorder (AUD) · Substance Use Disorder (SUD)
Primary: Change in Alcohol Use Disorder Severity — -2.65; -2.82 drinking days reduction
Phase 2 N=144 CAP: Doxazosin in the Treatment of Co-Occurring PTSD and Alcohol Use Disorders
Posttraumatic Stress Disorder · Alcohol Use Disorders
Primary: Clinician Administered PTSD Scale — 34.2; 32.5 score on a scale
N/A N=90 Cognitive Remediation for Alcohol Use Disorder and Posttraumatic Stress Disorder
Alcohol Use Disorder · PTSD · Cognitive Dysfunction
Primary: The Revised Hopkins Verbal Learning Test — 47.71; 44.14 units on a scale
Phase 4 N=165 Treatment for Alcoholism and Post-Traumatic Stress Disorder (Naltrexone)
Alcoholism · Alcohol Dependence · Post-Traumatic Stress Disorder
Primary: Posttraumatic Stress Disorder (PTSD) Symptom Scale - Interview (PSS-I-IV) — 27.1; 30.3; 27.7; 27.5 units on a scale
Phase 2 N=182 Clinical Trial for Alcohol Use Disorder and Post Traumatic Stress Disorder (PTSD)
Post Traumatic Stress Disorder (PTSD) · Addiction · Alcohol Abuse
Primary: Change in Alcohol Use Severity — -3.406; -3.934 standard drinks per day
Phase 2 N=30 Cannabidiol as a Treatment for AUD Comorbid With PTSD
Alcohol Use Disorder · Post Traumatic Stress Disorder
Primary: Number of Drinks Per Day — 4.4885; 5.3623 drinks/day
Phase 4 N=30 Topiramate Treatment of Alcohol Use Disorders in Veterans With Post Traumatic Stress Disorder (PTSD): A Pilot Controlled Trial of Augmentation Therapy
PTSD · Alcohol Abuse · Alcoholism
Primary: Percent Drinking Days (%DD) — 19.5; 39.7 percent days in a week — p=0.019
Phase 4 N=151 A Controlled Trial of Topiramate Treatment for Alcohol Dependence in Veterans With PTSD
Alcohol Dependence · Posttraumatic Stress Disorder (PTSD)
Primary: Change in Percentage of Heavy Drinking Days Over the 12 Weeks of Study Treatment as Assessed by the Timeline Followback (TFLB) — -36.2; -25.1 percent heavy drinking days
N/A N=131 Neurobiological Responses in Alcoholism and Early Trauma
Alcohol Use Disorder · Early Trauma Complications
Primary: Brain Response — .015; .010; -.013; .08 unitless — p=<0.05
N/A N=126 Mechanisms of Change, Motivation, and Treatment Outcome in Alcohol Dependence - Posttraumatic Stress Disorder
Alcohol Dependence · Posttraumatic Stress Disorder
Primary: Impact of Event Scale-Revised — 26.00; 19.10; 14.11 units on a scale — p==.068
N/A N=52 Prolonged Exposure Therapy for PTSD and Opioid Use Disorder
Post Traumatic Stress Disorder · Opioid-use Disorder
Primary: Change in Posttraumatic Stress Disorder (PTSD) Symptom Severity — -11.4; -12.8; -18.3 Score on a scale
Phase 2 N=30 Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder
Alcohol Abuse · Posttraumatic Stress Disorder
Primary: Percent Drinking Days Per Week — 18.1; 49.3 percentage of drinking days per week
Phase 3 N=88 Naltrexone & SSRI in Alcoholics With Depression/PTSD
Alcoholism · Depression · PTSD
Primary: Mean Self-report Weekly Craving Via Obsessive Compulsive Drinking Scale (OCDS) — 21.273; 20.700; 18.500; 21.458 units on a scale
N/A N=63 Primary Care Treatment Integrating Motivation and Exposure
Stress Disorders, Post-Traumatic · Alcohol-Related Disorders
Primary: Change in Clinician Administered PTSD Scale (CAPS)-5 Severity Rating — 28.46; 33.45 score on a scale
N/A N=10 Adapting and Piloting Behavioral Activation for Veterans With Alcohol Use Disorder and Posttraumatic Stress Disorder
Alcohol Use Disorder · Posttraumatic Stress Disorder
Primary: Timeline Follow-Back (Alcohol Use) — 4.36; 3.90; 1.82; 3.31 Drinks per day — p=0.4174
Phase 2 N=35 N-acetylcysteine in the Treatment of PTSD and Addiction
PTSD · Addiction
Primary: PTSD Symptoms — 38.7; 52.8; 32.0; 51.5 units on a scale
N/A N=27 Integrated Treatment for Posttraumatic Stress Disorder and Substance Abuse in Young Adults
Substance Use Disorder · Posttraumatic Stress Disorder
Primary: Change in Severity of Posttraumatic Stress Disorder Symptoms as Measured by the National Stressful Events PTSD Scale — 1.92; 2.61 score on a scale — p=.041
Phase 1 N=26 Citalopram Effects on Craving and Dopamine Receptor Availability in Alcoholics
Alcohol Dependence
Primary: Craving for Alcohol in Alcohol Dependence With Citalopram Compared to Placebo — 21; 30.4; 10.8; 10.6 score on a scale
Phase 3 N=96 Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD).
Alcohol Dependence · Stress Disorders, Post-Traumatic
Primary: Number of Drinking Days — 11.04; 9.21 days
N/A N=346 Evaluation and Treatment of Substance Abuse in Veterans With PTSD Disability Claims
Attendance at Treatment · PTSD, Substance Use, and Attendance at Treatment
Primary: Treatment Attendance by Treatment Group Over Time — 0.75; 0.53; 0.83; 0.89 weeks
N/A N=102 Prazosin Augmentation of Outpatient Treatment of Alcohol Use Disorders in Active Duty Soldiers With and Without PTSD
Alcohol Use Disorders · Stress Disorders, Posttraumatic · Combat Disorders
Primary: Change in Penn Alcohol Craving Scale Score — 7.4; 8.8 units on a scale
N/A N=117 SUPER Study (Substance Use and PTSD Treatment Effectiveness Research Study)
Substance Use Disorders · Posttraumatic Stress Disorder
Primary: Severity of Alcohol Use (ASI Alcohol Composite Scores) — .259; .225; .169; .152 units on a scale — p=> .05