Clinical Trial Search

Primary: Change in Number of Subjects Without Oxygenation Abnormalities — 12; 10 Participants — p=0.54

Primary: Change in Behavioral Index After 6 Months of CPAP or No-CPAP — -2.7; .9; -1.2 T score — p=0.07

Primary: Number of Participants Who Achieved Criteria of Obstructive Sleep Apnea in the PVT Assessment — 5; 2 Participants

Primary: Improvements in Attention/Executive Domain Index of the Developmental Neuropsychological Assessment (NEPSY) From Baseline to 7 Months. — 7.1; 5.1 units on a scale — p=0.16

Primary: Apnea-hypopnea Index (AHI) Using the New Pediatric Mask (Pixi) Compared to the Child's Currently-used Mask — 2.7 AHI (events/hour)

Primary: Change in Epworth Sleepiness Scale From Baseline to End of Study — -1; -0.5; 1 units on a scale

Primary: Difference Between Optimal Pressure (cm H2O) Derived From APAP run-in Period Versus Result of CPAP Titration Study — 7.3; 9.4 cmH2O

Primary: Obstructive Apnea Hypopnea Index — 7.69; 6.33 events per hour

Primary: Serious Adverse Events — 7 participants

Primary: Ability to Tolerate Measured by Percent of Participants With Protocol Goal — 50 percent of participants

Primary: Respiratory Depression Following Opioids — -38.1; -37.1 percentage of change from baseline

Primary: Number of Participants With a Negative Obstructive Sleep Apnea (OSA) Home Sleep Test Result — 61 Participants

Primary: Change in Cerebral Blood Flow (CBF) at Baseline Between Obstructive Sleep Apnea Syndrome (OSAS) and Controls — 184; 209 percentage of change from baseline

Primary: Minutes of Use Per Night at Month 1 — 185; 201 minutes — p=0.512

Primary: Obstructive Apnea-hypopnea Index (oAHI) — -3.79; -3.51 events per hour

Primary: Participant Providing Feedback — 26 Participants

Primary: Positive Berlin Questionnaire Indicative of Sleep Disordered Breathing — 1343; 96 participants — p=0.001

Primary: Change From Baseline to 12 Months in Caregiver-reported Behavior Rating Inventory of Executive Function (BRIEF) Global Executive Composite (GEC) T Score — -1.90; -3.08…

Primary: Apnea Hypopnea Index (AHI) — 44.89; 44.65; 36.87 events per hour — p=<0.05

Primary: Number of Participants Who Completed Interviews Regarding Positive Airway Pressure (PAP) Acceptability — 20; 21 Participants

Primary: Change in Continuous Glucose Monitoring System Standard Deviation — 0.8; 1.1 mg/dL

Primary: Apnea-hypopnea Index (AHI) at One Year — 35.3; 39.6 events per hour

Primary: Greater Than or Equal to 6 Hours of Sleep Data — 1 Participants

Primary: Model Prediction of Absence/Presence of OSA: Ventilation That Causes an Arousal From Sleep (Varousal) — 5.7; 5.2 L/min — p=0.05

Primary: Number of Children Who Developed Postextubation Adverse Respiratory Events Compared to Placebo. — 21; 11 Participants

Primary: Effective Apnea Hypopnea Index — 29.5; 20.0 Events per hour

Primary: CPAP Adherence — 2.8; 3.9 hours per night — p=0.001

Primary: Ventilation (Aim 1) — 1.19; 1.14; 1.35; 1.16 fraction of baseline — p=0.001

Primary: Effect of CPAP on Neurocognitive Function: E/F Function- SWMT-OMD — 0.035; -0.074; 0.072; 0.018 score on a scale — p=0.0074

Primary: Cross Sectional Area of the Pharyngeal Airway — 239.9; 178.5; 201.6; 235.4 mm^2