N/A N=5,117 Periodontal Disease Prevention Study
Periodontitis
Primary: Percentage of Participants With Tooth Loss Over 16 Year Period — 16.4; 13.8; 22.1; 16.9 percentage of participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=155 Baseline Oral Health Study: UnCoVer the Connections to General Health
Cardiovascular Diseases · Diabetes Type 2
Primary: Impact of Treatment on Change in Oral Health Measures — 0.186; 0.190 millimeters (probing depth difference) — p=0.957
N/A N=70 Changes in the Risk Factors of Coronary Heart Disease Observed After Scaling and Root Planing
Coronary Heart Disease · Periodontitis
Primary: Change From Baseline in C-Reactive Protein Level at 6 Months — 6.30; 4.94 mg/L
Phase 3 N=33 The Effect of Periodontal Treatment and the Use of Dentifrice on Glycaemic Control in Diabetics
Periodontal Disease
Primary: HbA1c Levels in Blood — 9.47; 10.27 Percentage — p=0.05
Phase 2 N=114 Impact of Periodontal Therapy on Patients With Diabetes
Diabetes Mellitus, Type II · Periodontitis
Primary: Change in Probing Pocket Depth at the 6-month Post-SRP Completed at Baseline — -0.25; -0.18 mm — p=0.16
Phase 4 N=49 Compare Anti-inflammatory Dentifrices
Gingivitis
Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05
Phase 3 N=60 Effectiveness of a Triclosan Containing Toothpaste in Maintaining Periodontal Health in a Type 2 Diabetic Population
Periodontitis
Primary: HbA1c Levels in Blood — 11.42; 10.81 percentage of HbA1c levels in blood — p=0.05
Phase 4 N=113 Relationship of Periodontal Disease Treatment and Type 2 Diabetes Mellitus in the Gullah Population
Periodontal Disease · Type 2 Diabetes Mellitus
Primary: Glycated Hemoglobin A1c — 8; 8.2 percentage of Glycated Hemoglobin A1c
N/A N=60 Activated MMP-8 as Diagnostic Test for Periodontitis
Generalized Chronic Periodontitis
Primary: Percentage of True Positive/Negative aMMP-8 Tests of All Periodontitis Patients (Sensitivity/Specificity) — 87; 60 percentage of true cases (sens./spec.)
N/A N=172 Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome
Periodontal Diseases · Chronic Periodontitis · Periodontal Pocket
Primary: Periodontal Pocket Depth (PD) Change From Baseline at 6 Months — -1.046; -1.114; -1.177 millimeters — p=0.297
Phase 3 N=38 Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis
Aggressive Periodontitis
Primary: Change in Probing Depth — 3.88; 3.74; 3.38; 3.26 milimeters — p=<0.05
Phase 2 N=55 The Effects of DHA on Periodontitis
Periodontitis · Gingivitis · Inflammation
Primary: Change in Pocket Depth (mm) — -0.71; -0.54 mm — p=<0.05
N/A N=32 Induced Gingivitis & Intra-oral Imaging
Plaque Induced Gingivitis
Primary: Change From Baseline Gingivitis at Day 14 as Measured by Non-invasive Microimaging and Gingival Index. — 0.6; 0.15 units on a scale
N/A N=36 Macrophage Markers in Periodontal and Peri-implant Health and Disease
Peri-Implantitis · Periodontitis
Primary: CD80 — 7340.34; 10854.71; 6448.43; 9874.8 arbitrary density units
N/A N=30 Implant Surface Decontamination in Peri-implantitis Treatment
Peri-implantitis · Periodontal Disease
Primary: Change in Total Bacterial Load on the Exposed Implant Surface — 2.77; 4.21 log (colony forming units/ml)
N/A N=51 Kidney and Periodontal Disease Study
Chronic Kidney Disease · Periodontal Disease
Primary: Number of Participants Completing Study Protocol — 17; 34; 14; 30 Participants
Phase 2 N=38 Short-term Effect of 2% Atorvastatin Dentifrice in Periodontal Status.
Chronic Periodontitis
Primary: Change in Periodontal Inflammation Surface Area (PISA) — 638.16; 288.72 square millimeters
Phase 3 N=102 Periodontal Infection and Endothelial Dysfunction
Periodontitis
Primary: Brachial Artery Flow-mediated Dilation — 10.2; 10.3; 13.1; 8.1 Percentage of dilatation of brachial art — p=0.98
Phase 3 N=34 Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis
Residual Disease · Aggressive Periodontitis
Primary: Clinical Attachment Level at Baseline, 3 Months and 6 Months — 5.5; 5.29; 4.64; 4.73 mm
N/A N=34 Effect of Non-surgical Periodontal Therapy on Gingival Crevicular Fluid Interleukin-21 Levels
Chronic Peridontitis Patients · Chronic Gingivitis · Healthy
Primary: Pocket Depth — 1.60; 2.50; 6.75 millimetres
Phase 4 N=56 Clinical and Microbiologic Outcomes of aPDT in the Non-surgical Treatment of Implant Inflammation
DENT IMPLANTS · LASER
Primary: Mean Probing Pocket Depth — 4.62; 4.45 millimeters
Phase 3 N=39 Collection of Gingival Crevicular Fluid From Periodontitis Patients
Gingival Diseases
Primary: Metabolite Associated With Inflammation (Cadaverine) — 1.119186; 0.92077 ion count — p=<0.05
N/A N=10,069 Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi
Preterm Birth · Periodontal Disease · Caries, Dental
Primary: Rate of Preterm Birth — 878; 549 Participants — p=<0.05
N/A N=40 Clinical and Microbiologic Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-surgical and Surgical Treatment of Teeth With Periodontal Disease
Periodontal Diseases
Primary: Change in Number of Bleeding Sites (Bleeding On Probing) — -1.60; -1.40 bleeding sites
N/A N=44 Lactobacillus Reuteri in the Supportive Therapy of Periodontitis
Periodontal Diseases
Primary: Change in PD (Periodontal Depth) — 5.63; 5.45; 4.01; 4.03 millimeter
N/A N=41 Clinical and Radiographic Evaluation of Demineralized Freeze-Dried Bone Allograft Versus Platelet Rich Fibrin for the Treatment of Periodontal Intrabony Defects in Humans
Periodontitis
Primary: Change in Clinical Attachment Level (CAL) — 1.21; 1.03 mm
N/A N=288 Oral Health Educational Methods in Adolescence
Adolescent Behavior
Primary: Knowledge Score — 11; 13; 11; 13 score on a scale — p=0.001
Phase 2 N=146 Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers
Periodontitis · Periodontal Diseases
Primary: Change in Mean Clinical Attachment Level. — 0.11; 0.10; 0.21; 0.08 mm — p=>0.05
Phase 4 N=70 Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg
SRP · Minocycline HCl Microspheres · Biomarkers
Primary: Bacteria Load (log10) — -11.3; -10.9 log 10 copies/mL
Phase 4 N=51 Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis
Periodontitis
Primary: Periodontal Probing Depth — 2.5; 3.2; 3.4 millimeter