Clinical Trial Search

Primary: Number of Participants Improved as Measured by the Clinical Global Impression-Global Improvement Scale (Improvement Defined as CGI-I=1 or CGI-I=2) — 11; 3 participants

Primary: Number of Confirmed Social Responsiveness Scale (SRS) Responders — 517; 351 participants

Primary: Mean 10-Week Change in Pediatric Anxiety Rating Scale 5-Item Total Score, Double-blind Phase — -4.9; -3.2 score on a scale

Primary: Social Responsiveness Scale (SRS) Change — -13.39; -17.00 units on a scale — p=0.45

Primary: Proportion of Patients Meeting the Criterion for Loss of Therapeutic Response (LTR) by the End of the Study (Based on Observed Cases) — 69.0; 67.5; 66.7 Percentage of…

Primary: Change From Baseline in Communication During Structured Lab Observation (SLO) at 12 Weeks — 45.7; 40.8; 64.5; 51.4 Utterances — p=0.42

Primary: Change From Baseline in the Pervasive Developmental Disorder-Behavioral Inventory (PDDBI) - Autism Composite Score — -4.5; -6.4 units on a scale — p=0.5

Primary: Aberrant Behavior Checklist Hyperactivity Subscale — 19.3; 29.7 units on a scale

Primary: Clinical Features of Concordant vs Discordant Groups — 76.18; 89.85; 14.96; 13.94 units on a scale

Primary: ABC - Social Withdrawal Subscale — 10.31; 4.6; 14.8; 6.2 score on a scale

Primary: Peroxisome Biochemical Functions as Measured by Plasma Very Long Chain Fatty Acid — 0.180; 0.188 ratio

Primary: Pediatric Anxiety Rating Scale (Measures the Severity of Anxiety Symptoms) — 16.33; 17.62; 11.58; 16.05 units on a scale

Primary: Change in Score on Conners Adults Attention Deficit Hyperactivity Disorder (ADHD) Rating Scale — 68.6; 71.8; 53.4; 57 T-score

Primary: Intelligence Quotient — 85.9; 104.3; 103.2 units on a scale

Primary: Eyberg Child Behavior Inventory — 132.50; 154.33; 18.9; 19.11 units on a scale

Primary: Change in Mean Percent of Parent Child Dyadic Engagement Over Time From Baseline to Posttest 1 — 22.01; 16.91; 26.55; 27.09 percent time in dyadic engagement — p=0.028

Primary: Social Responsiveness Scale (SRS) — 16.5; 89.06; 14.5; 79.8 Points

Primary: Number of Participants Reporting Improvement on the Clinical Global Impression — 1; 10 Participants

Primary: Pediatric Anxiety Rating Scale. — 11.62; 14.04 units on a scale — p=.04

Primary: Change From Baseline in Autism Diagnostic Observation Schedule(ADOS) at 4 Month — 3.3; 3.6; 7.5; 8.8 score on a scale

Primary: Change From Baseline in Anxiety Severity on the Pediatric Anxiety Rating Scale After 16 Weeks of Treatment. — 3.43; 3.47; 3.28; 2.13 units on a scale

Primary: Change From Baseline in Parent Rated Social Responsiveness Scale (SRS) Scores During Treatment. — 9.73; 3.18 units on a scale — p=0.0275

Primary: The Effects of rTMS on Reciprocal Social Awareness — 68; 79.667; 64.2; 74 total raw score (higher=worse)

Primary: Phenylalanine Level in the Brain as Determined by MR Spectroscopy and in Blood — 130; 137; 961 umol/L

Primary: Change From Baseline at Week 6 in Caregiver-rated Aberrant Behavior Checklist Irritability (ABC-I) Subscale Score — -9.6; -11.2; -11.2 score on a scale — p=0.2986

Primary: Verbal Fluency — 9.3; 10.5; 9.9; 8.3 units on a scale

Primary: Difference in the Number of Participants Who Completed Early Intervention Intake and Evaluation Visits Between Treatment Groups — 20; 21; 17; 17 participants

Primary: Change in Patient Quality of Life as Measured by the EuroQol 5-D (EQ-5D) Scale Between Baseline (Visit 1) and 1 Year (Visit 4) — 1; 0.5; 0.5; 0 units on a scale — p=0.59

Primary: Change From Baseline in Aberrant Behavior Checklist-Irritability at 12 Weeks — 7.6; -0.6 units on a scale

Primary: ADHD Rating Scale (ADHDRS)-Home Version Total Score (Randomized Phase) — 28.7; 34.0 units on a scale