N/A N=47 Post-Operative Cognitive Dysfunction in Normal Aging Patients Undergoing Elective Orthopedic Surgery
Post Operative Cognitive Dysfunction
Primary: Presence of Post Operative Cognitive Dysfunction (POCD) — 15 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=203 Postoperative Cognitive Dysfunction as Geriatric Syndrome
Cognitive Dysfunction
Primary: Postoperative Cognitive Dysfunction - Results of MMSE Before Operation — 79; 43; 37; 5 Participants — p=<0.0001
N/A N=45 Prevention of Early Postoperative Decline
Delirium · Postoperative Cognitive Dysfunction
Primary: Feasibility of Providing a Neurocognitive Training Program to Elderly Cardiac Surgical Patients - Enrollment — 45 Participants
N/A N=229 Preoperative Cognitive Screening in Older Spinal Surgical Patients
Cognitive Impairment · Frail Elderly Syndrome
Primary: Delirium by Age — 75; 77 years — p=0.508
Phase 4 N=404 Perioperative Cognitive Function - Dexmedetomidine and Cognitive Reserve
Postoperative Delirium · PD · Postoperative Cognitive Dysfunction
Primary: Delirium Battery — 23; 23; 6; 8 Participants
N/A N=30 Assessment of Cognitive Function After Surgery in Two Types of Anesthesia in Patients Operated for Breast Cancer
Patients With Breast Cancer and Breast Surgery Requiring
Primary: Presence of Cognitive Impairment — 29.5; 29 score on a scale
Phase 4 N=120 Effect of Intraoperative Dexmedetomidine on Early Postoperative Cognitive Dysfunction
Cognitive Dysfunction
Primary: Number of Cases Developing POCD — 10; 21 Participants
Phase 4 N=100 The Effect of Dexmedetomidine Infusion on Post-operative Cognitive Function and Oxidative Stress in Cardiac Surgery
Oxidative Stress · Cognition Disorders
Primary: Numbers of Participants With Postoperative Cognitive Dysfunction (POCD) — 12; 8 Participants — p=0.289
N/A N=200 Preoperative Cognitive Screening of Elderly Surgical Patients
Cognitive Impairment
Primary: Number of Patients With Probable Cognitive Impairment — 23; 22 Participants
N/A N=200 Cerebral Oximetry and Neurocognitive Functions in Cardiosurgical Patients
Coronary Artery Disease · Postoperative Cognitive Dysfunction · Neurological Impairment
Primary: Difference in Incidence of Cognitive Impairment Between Groups. Change Between Preoperative and Postoperative Cognitive Function Was Assessed by Performing Standardized…
N/A N=200 Post-Operative Delirium in Elderly Surgical Patients
Hip Fractures · Delirium
Primary: Number of Participants With the Presence of Delirium as Assessed by the Confusion Assessment Method — 39; 34 Participants
Phase 2 N=22 Cardiac Surgery Neuroprotection Study in Elders
Post-operative Cognitive Decline · Post-operative Delirium
Primary: Change From Baseline Cognitive Function
Phase 4 N=191 Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care
Alzheimers Disease · Postoperative Delirium · Post Operative Cognitive Dysfunction
Primary: Correlation Between Perioperative Change in Cerebrospinal Fluid (CSF) Markers of Alzheimers Disease and Perioperative Cognitive Change — -1.21; -5.09; -0.44 pg/ml
N/A N=250 Assessing the Incidence of Postoperative Delirium Following Aortic Valve Replacement
Postoperative Delirium · Aortic Valve Stenosis
Primary: Number of Participants With Postoperative Delirium — 13; 41; 45 Participants — p=<0.0001
N/A N=91 Postoperative Delirium: Brain Vulnerability and Recovery
Delirium · Postoperative Complications
Primary: EEG During Delirium and After Recovery and in Patient Controls.
Phase 4 N=28 Rivastigmine in the Treatment of Postoperative Delirium: a Pilot Clinical Trial
Delirium · Postoperative Cognitive Dysfunction
Primary: Incidence of POD — 2; 4 participants
N/A N=199 Cognitive Effects of Inhalational Versus Intravenous General Anesthesia in the Elderly
Lumbar Spondylosis · Cervical Spondylosis · Hip Osteoarthritis
Primary: Change in Neurocognitive Performance (Z-score) — .09; -.20; -.42; .01 z score
Phase 4 N=60 Comparison of Postoperative Delirium in Patients Anaesthetised With Isoflurane and Desflurane During Spinal Surgery
Postoperative Delirium
Primary: Comparison of Postoperative Delirium(POD) With Isoflurane and Desflurane on Adults Undergoing Spine Surgery — 3; 4; 27; 26 Participants
N/A N=104 Trajectory of Recovery in the Elderly
Delayed Emergence From Anesthesia · Postoperative Delirium · Postoperative Cognitive Dysfunction
Primary: Number of Participants Recovered on Postoperative Quality of Recovery Scale (PQRS) — 3; 5; 1; 3 Participants
Phase 4 N=285 Dexmedetomidine and Delirium in Patients After Cardiac Surgery
Delirium · C.Surgical Procedure; Cardiac · Postoperative Complications
Primary: Incidence of Postoperative Delirium — 7; 11 Participants — p=0.341
Phase 4 N=41 Cognitive Functions After TIVA With Dexmedetomidine
Postoperative Confusion
Primary: Mini Mental State Examination (MMSE) Score at the Second Hour After Surgery — 27.40; 26.45 scores on a scale
Phase 2 N=189 Modulating ApoE Signalling to Reduce Brain Inflammation, deLirium and postopErative Cognitive Dysfunction
Postoperative Delirium · Postoperative Cognitive Dysfunction
Primary: Number of Adverse Events (AEs) of Grade II or Higher Per Patient — 1; 2 events per participant — p=0.025
N/A N=135 Effect of CPAP on Postoperative Delirium
Sleep Apnea, Obstructive · Delirium
Primary: Presence of Postoperative Delirium — 4.8; 5.1; 7.8; 8.1 units on a scale
N/A N=90 Prospective Evaluation of Cognitive Outcomes After Anesthesia on Patients in the Beach Chair Position
Injury as a Result of Positioning
Primary: Percentage of Participants With 20+% Cerebral Desaturation Events — 40; 40 Participants
Phase 4 N=121 Dexmedetomidine and IV Acetaminophen for the Prevention of Postoperative Delirium Following Cardiac Surgery
Delirium
Primary: Incidence of Delirium — 2; 4; 8; 9 Participants
N/A N=22 Improved Patient Recovery After Anesthesia With Hypercapnia Hyperpnoea
Hypercapnia
Primary: Recovery From Anesthesia — 53.0; 62.9 minutes — p=>0.05
Phase 4 N=57 Recovery Following Desflurane Versus Sevoflurane for Outpatient Urologic Surgery in Elderly Females
Ureteral Stent Occlusion · Exposure Laser · Ureterostomy; Functional Disturbance
Primary: Time to Opening of Eyes — 391.2; 446.5 seconds
Phase 2 N=24 Oxidative Stress and Surgical Recovery
Surgical Recovery · Pain, Postoperative
Primary: Phosphorylation of STAT-3 in MDSC (Myeloid-derived Suppressor Cells) — 2.162; 2.025 STAT3 archsinh ratio — p=0.5490
Phase 2 N=86 The Influence of Postoperative Analgesia on Systemic Inflammatory Response and POCD After Femoral Fractures Surgery
Postoperative Cognitive Dysfunction
Primary: Interleukin-6 Concentration in Peripheral Blood. — 27.2; 26.6; 104; 97.7 pg/ml
N/A N=36 Emergence From Anesthesia in Anterior Temporal Lobectomy and Amygdalohippocampectomy Patients
Emergence From Anesthesia
Primary: Volumes of the Hippocampus, Thalamus and Amygdala — 3578; 3903; 3479; 3525 mm3