Phase 4 N=100 Intravenous Acetaminophen in Craniotomy
Postoperative Pain
Primary: Post-Operative Opioid Requirement — 11.0; 10.1 Morphine Equivalents
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=60 Cerebral Blood Perfusion Changes After General Anesthesia for Craniotomy
Brain Neoplasms · Surgery · Hyperemia
Primary: Mean Blood Flow Velocity in Middle Cerebral Artery — 63.7; 61.8 cm/s — p=0.554
N/A N=36 Emergence From Anesthesia in Anterior Temporal Lobectomy and Amygdalohippocampectomy Patients
Emergence From Anesthesia
Primary: Volumes of the Hippocampus, Thalamus and Amygdala — 3578; 3903; 3479; 3525 mm3
Phase 1 N=40 Feasibility of Aromatherapy in an Awake Craniotomy Environment
Intracranial Pathology
Primary: Number of Consented Patients — 40 Participants
Phase 3 N=159 IVPCA in the Management of Pain Following Major Intracranial Surgery
Intracranial Surgery
Primary: Hourly Pain Scores — 2.5; 3.6; 3.7; 5.2 units on a scale
Phase 4 N=27 The Effect of Intravenous Acetaminophen on Post-Operative Pain After Craniotomy
Pain
Primary: Post-operative Opioid Consumption — 228; 312 ug
Phase 4 N=140 The Efficacy of Intravenous Acetaminophen During Perioperative Neurosurgery Period
Craniotomy · Brain Surgery
Primary: Opioid Requirement After Surgery — 10; 4 Participants
N/A N=460 Cerebral Autoregulation Monitoring During Cardiac Surgery
Thoracic Surgery · Cardiopulmonary Bypass
Primary: Composite Neurological Outcome of Clinical Stroke or New Ischemic Brain Lesion on Diffusion Weighted MRI or Neurocognitive Dysfunction 4 to 6 Weeks After Surgery. — 79…
N/A N=68 Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients
Intracranial Aneurysm · Brain Edema · Scoliosis
Primary: Number of ICU Stays Greater Than 1.5 Days — 13; 20 Number of ICU Stays greater that 1.5 Day
N/A N=37 Ventriculostomies in SAH: ICP Open or Not?
Subarachnoid Hemorrhage
Primary: Cerebral Artery Vasospasm — 16; 7 Participants
N/A N=494 Postoperative Headache in Elective Surgery Patients
Drug Withdrawal Headache
Primary: Frequency of Postoperative Headache in Elective Surgery Patients — 126; 37; 89 participants
N/A N=43 Peri-Operative Steroid Management in Patients
Pituitary Adenoma · Pituitary Diseases
Primary: Number of Participants With Adrenal Insufficiency — 2; 1 Participants
N/A N=91 Postoperative Delirium: Brain Vulnerability and Recovery
Delirium · Postoperative Complications
Primary: EEG During Delirium and After Recovery and in Patient Controls.
Phase 2 N=122 Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)
Severe Traumatic Brain Injury
Primary: Fraction of Time That Brain Oxygen Levels Are Below the Critical Threshold of 20 mm Hg . — 0.15; 0.44 Proportion
N/A N=58 Functional Monitoring for Motor Pathway in Brain Tumor Surgery Within Eloquent Area
Glioma, Motor Pathway
Primary: Extent of Tumor Resection — 40; 7; 7; 4 participants
N/A N=12 MRI for Non-invasive Evaluation of Brain Stress
Craniosynostosis
Primary: Blood Flow and Perfusion — 26.8 ml/min/100g — p=0.004
Phase 3 N=80 Magnesium and Intraoperative Blood Loss in Meningioma Surgery
Meningioma
Primary: Intraoperative Blood Loss — 510; 500 ml — p=0.315
Phase 4 N=21 Time to Post-Anesthesia Neurological Evaluation With Three Different Anesthetic Techniques
Carotid Artery Stenosis
Primary: Time to First Neurological Exam — 9; 7; 7 Minutes
N/A N=47 Post-Operative Cognitive Dysfunction in Normal Aging Patients Undergoing Elective Orthopedic Surgery
Post Operative Cognitive Dysfunction
Primary: Presence of Post Operative Cognitive Dysfunction (POCD) — 15 Participants
N/A N=203 Postoperative Cognitive Dysfunction as Geriatric Syndrome
Cognitive Dysfunction
Primary: Postoperative Cognitive Dysfunction - Results of MMSE Before Operation — 79; 43; 37; 5 Participants — p=<0.0001
Phase 4 N=62 Analgesia Regimens Following Trans-sphenoidal Surgery for Pituitary Tumors
Pituitary Tumor · Pain
Primary: Comparison of Mean Pain Scores Between Two Arms (Measured Every 4 Hours Over 48 Hour) — 1.7; 2.8 0-10 units on a scale
Phase 4 N=22 A Pilot Study to Evaluate Efficacy and Safety of Clevidipine in Neurosurgical Patients
Hypertension · Brain Tumor · Epilepsy
Primary: The Primary Endpoint of This Trial is the Proportion of Patients Who Did Not Require Rescue Antihypertensive Medication to Maintain SBP Below 130 mmHg (i.e. Clevidipine…
N/A N=63 Intraoperative Ocular Pressure in Lumbar Spine Fusion Patients
Raised Ocular Pressure
Primary: Change in Intraoperative Ocular Pressure in Lumbar Spine Fusion Patients Head Raised 10 Degrees or Kept in Neutral Position — 9.26; 13.79 mm Hg
N/A N=817 Neuropsychometric Outcome After Carotid Endarterectomy
Carotid Artery Stenosis · Carotid Artery Disease · Transient Ischemic Attack
Primary: Percentage of Patients Having a Significant Change in Neuropsychometric Performance After Carotid Endarterectomy — 22; 4.5 percentage of participants
Phase 4 N=137 Safety Study of Analgesia After Craniotomy Surgery With End Tidal (ET) Carbon Dioxide (CO2) Monitoring
Pain
Primary: Respiratory Depression — 10.9; 10.5 breaths/minute
Phase 4 N=100 Regional Block for Postoperative Free Flap Care
Pain Management
Primary: Opioid Utilization Measured in Oral Morphine Equivalent (OME) — 118; 166 mg
N/A N=229 Preoperative Cognitive Screening in Older Spinal Surgical Patients
Cognitive Impairment · Frail Elderly Syndrome
Primary: Delirium by Age — 75; 77 years — p=0.508
N/A N=9 Cranial Osteopathic Manipulative Medicine as an Adjunct Treatment for Concussion
Concussion Injury of Cerebrum · Cranial Osteopathic Medicine
Primary: Change in Concussive Symptoms on the Post Concussion Symptom Scale — 9 units on a scale
N/A N=10 Correlating Brain Tissue Oxygen and Regional Cerebral Oximetry
Stroke
Primary: Correlation Between Regional Cerebral Oximetry (RSO2) and Cerebral Oxygen Tissue Tension (PbrO2). — .5 Spearman Correlation (rs) Coefficient — p=0.036
N/A N=200 Cerebral Oximetry and Neurocognitive Functions in Cardiosurgical Patients
Coronary Artery Disease · Postoperative Cognitive Dysfunction · Neurological Impairment
Primary: Difference in Incidence of Cognitive Impairment Between Groups. Change Between Preoperative and Postoperative Cognitive Function Was Assessed by Performing Standardized…