N/A N=92 Epidural Neuroplasty for the Treatment of Herniated Lumbar Disk
Herniated Lumbar Disc
Primary: Pain Assessed by Visual Analogue Scale — 5.63; 5.92 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=15 Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® Disc Augmentation System: A Pilot Study
Low Back Pain
Primary: Numbers and Types of Adverse Events (Only Number of Events is Reported in This Section - See Adverse Events Section for Further Detail) — 17 Events
N/A N=40 Percutaneous Diskectomy SpineJet x Open Microdiskectomy in Treatment of Lumbar Radiculopathy
Radiculopathy · Herniated Disk
Primary: VAS for Lumbar Pain in 3 Months — 2.63; 4.53 units on a scale — p=0.05
N/A N=59 Benefit of Lumbar Bracing for Chronic Low Back Pain Due to Degenerative Disc Disease
Degenerative Disc Disease · Lumbar Spondylosis · Low Back Pain
Primary: Pain Diary — 6.71; 5 units on a scale
Phase 2 N=32 Intradiscal rhGDF-5 Phase I/II Clinical Trial
Degenerative Disc Disease
Primary: Neurological Assessment for Motor Function and Reflexes/Sensory — 0; 0 participants
N/A N=376 Activ-L™ Artificial Disc Treatment of Degenerative Disc Disease in the Treatment of Degenerative Disc Disease
Degenerative Disc Disease
Primary: Overall Success at 24 Months Relative to Baseline — 42.2; 28.3; 61.9; 52.8 percentage of participants — p=<0.05
N/A N=20 TRIUMPH Lumbar Artificial Disc IDE: A Pilot Study
Lumbar Degenerative Disc Disease
Primary: Number of Participants With a Change of at Least 15 Points in Pain/Disability Using the Oswestry Disability Index (ODI) Score at 24 Months Compared With the Score at…
Phase 3 N=352 SI-6603 (Condoliase) Study for Lumbar Disc Herniation (Discovery 6603 Study)
Lumbar Disc Herniation
Primary: Change From Baseline to Week 13 in Average Worst Leg Pain Score During the Past 24 Hours Over the Previous 7 Days — -41.7; -34.2 units on a scale — p=0.0263
Phase 4 N=146 Herniectomy Versus Herniectomy With a Spinal Stabilization System for the Treatment of Complex Disc Disease
Sciatica · Back Pain
Primary: To Demonstrate a Statistically Significant Difference in the Relief of Back Pain Between Both Treatment Groups. The Endpoint Will be the Difference Between Baseline and…
Phase 3 N=991 A Study of SI-6603 in Patients With Lumbar Disc Herniation
Intervertebral Disc Disease · Lumbar Disc Disease
Primary: Number of Participants With Treatment-Emergent Adverse Events (TEAE) — 615 Participants
N/A N=178 Lumbar Degenerative Disc Disease Treated With Anterior Tension Band System (ATB) With ALIF/FRA Spacer
Lumbar Degenerative Disc Disease
Primary: Number of Subjects With Successful Radiographic Fusion — 90 Participants
N/A N=63 Safety and Efficacy of the TransDiscal System Versus Medical Management in Treating Chronic Discogenic Low Back Pain
Back Pain
Primary: Change in Average Daily Pain Visual Analog Scale (VAS) Score Between Screening and Follow up. — -2.4; -0.56 units on a scale
N/A N=852 Safety and Effectiveness Study of Prodisc to Spinal Fusion Surgery
Spinal Diseases
Primary: Overall Success — 45.1; 63.5; 66.7; 53.3 percentage of overall successes
Phase 4 N=13 Milnacipran for Lumbosacral Radicular Pain
Radicular Pain Related to Lumbosacral Disc Disease
Primary: Visual Analogue Scale Score Referring to Radicular Pain (VAS-rad) — 58.7; 67.7; 13.6; 59.7 units on a scale
Phase 2 N=31 A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration
Early Lumbar Disc Degeneration
Primary: Neurological Assessment for Motor Function and Reflexes/Sensory — 0; 0 participants
N/A N=30 Trial Evaluating the Safety and Effectiveness of NUBAC™ Disc Arthroplasty
Degenerative Disc Disease
Primary: Participants With Improved Patient Function — 7; 6 participants — p=1.0
Phase 2 N=24 A Multicenter, Randomized, Double-blind, Placebo Controlled, Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of 2 Doses of Intradiscal rhGDF-5 (Single Administration) for the Treatment of Early Stage Lumbar Disc Degeneration
Degenerative Disc Disease
Primary: Neurological Assessment for Motor Function and Reflexes/Sensory — 0; 0 participants
N/A N=75 Gait in Low Back Pain Patients After Spinal Mobilization
Chronic Low Back Pain
Primary: Change in the Numerical Pain Rating Scale — 5.96; 6.12; 6; 1.22 units on a scale
Phase 2 N=40 A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration
Early Lumbar Disc Degeneration
Primary: Neurological Assessment for Motor Function and Reflexes/Sensory — 0; 2 participants
N/A N=20 Study to Evaluate the Effectiveness of DRG Stimulation for Discogenic Low Back Pain
Chronic Pain
Primary: Percentage of Subjects With 30% or Greater Reduction in Back Pain at 6 Months — 11 Participants
Phase 2 N=24 A Study to Evaluate Safety and Exploratory Efficacy of KTP-001 in Subjects With Lumbar Disc Herniation
Lumbar Disc Herniation
Primary: Safety Assessed by Adverse Events, Magnetic Resonance Imaging (MRI), X-ray Imaging, Physical Examination, Neurologic Examination and Vital Signs — 6; 6; 6; 5 Participants
Phase 3 N=82 A Trial of Corticosteroids for Low Back Pain
Radicular Low Back Pain
Primary: Numerical Rating Scale (0-10), an Interval Pain Scale, on Which 0 Indicates no Pain and 10 Indicates the Worst Pain Imaginable — 7.1; 5.8 units on a scale
N/A N=10 The Vertos MILD™ Preliminary Patient Evaluation Study
Lumbar Spinal Stenosis
Primary: Changes in Back Pain as Measured by a 10-point Visual Analog Scale (VAS). — 3.3 units on a scale
Phase 4 N=62 Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain
Low Back Pain
Primary: Difference in Number of Magnetic Resonance Imaging (MRI)-Positive Discs Diagnosed Positive by Provocative Discography (PD) and Functional Anesthetic Discography (F.A.D.)…
N/A N=337 5-Year Global Study on MAST™ Minimally Invasive Fusion Procedures to Treat Degenerative Lumbar Spine (MASTERS-D2)
Intervertebral Disc Degeneration
Primary: Change (Preop-postop) of Disability, Oswestry Disability Index (ODI) at 3 Months as Compared to Baseline in DDD Patients With Spondylolisthesis — 23.19; 26.08 change of…
N/A N=575 LDR Spine USA Mobi-C(R) Cervical Disc Prosthesis IDE
Degenerative Disc Disease
Primary: Composite Definition of Study Success — 65.3; 73.7; 37.4; 69.7 percentage of subjects analyzed — p=0.0021
N/A N=120 Effectiveness of Percutaneous Lumbar Epidural Adhesiolysis and Neurolysis on Low Back Pain
Low Back Pain
Primary: Numeric Pain Rating Score — 7.9; 8.1; 4.9; 3.4 units on a scale — p=<0.001
Phase 4 N=39 Efficacy of Pregabalin in Patients With Radicular Pain
Neuropathy; Radicular, Lumbar, Lumbosacral · Failed Back Surgery Syndrome · Spinal Stenosis
Primary: Pain Scores (NRS) at 3-weeks — 6; 3 units on a scale — p=0.279
N/A N=196 Efficacy of Acupuncture for Lumbar Spinal Stenosis
Lumbar Spinal Stenosis · Intermittent Claudication
Primary: The Change in Modified Roland-Morris Disability Questionnaire (RMDQ) Score From Baseline — -4.3; -3.0 score on a scale
N/A N=397 Study of the Safety and Effectiveness of the Artificial Cervical Disc - Low Profile Device at Two Adjacent Levels
Cervical Degenerative Disc Disease · Radiculopathy · Myelopathy
Primary: Rate of Overall Success — 81.4; 69.4 percentage of participants — p=1.000