Phase 4 N=35 Circadian Ocular Perfusion Pressure and Ocular Blood Flow
Glaucoma
Primary: Mean Change From Baseline in Overall Diastolic Ocular Perfusion Pressure at Week 6 — 2.6; 0.8 mmHg (millimeters of mercury)
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=63 Intraoperative Ocular Pressure in Lumbar Spine Fusion Patients
Raised Ocular Pressure
Primary: Change in Intraoperative Ocular Pressure in Lumbar Spine Fusion Patients Head Raised 10 Degrees or Kept in Neutral Position — 9.26; 13.79 mm Hg
N/A N=100 Optic Nerve Sheath Diameter (ONSD) With the Raised PCO2 and Internal Jugular Venous Occlusion
Elevated Intracranial Pressure (ICP)
Primary: Changes in ONSD in mm With Changes in ICP in Healthy Volunteers. — 4.2 mm
N/A N=112 The Effects of Caffeinated Coffee on Intraocular Pressure
Primary Open Angle Glaucoma
Primary: Change in Intraocular Pressure at 60 Minutes — 1.51; 0.52 mm Hg
N/A N=4,812 A Study of Intraocular Pressure (IOP) Reduction in Newly Diagnosed Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT)
Glaucoma, Open-Angle · Ocular Hypertension
Primary: Percentage of Patients With a Reduction in Intraocular Pressure (IOP) ≥ 5mmHg From Baseline — 75.9 Millimeters of Mercury (mmHg)
Phase 2 N=50 A Phase IIa Study to Assess the Tolerability, Safety, and Efficacy of AZD4017 for Raised Intra-ocular Pressure
Raised Intraocular Pressure
Primary: Percentage Change in Mean Intra-ocular Pressure Compared With Baseline After 4 Weeks Treatment — 0.8; -0.4; -8.1; -11.0 Percentage change — p=0.822
Phase 2 N=67 Safety and Efficacy of PF-04217329 in Patients With Glaucoma or Elevated Eye Pressure.
Primary Open-Angle Glaucoma · Ocular Hypertension
Primary: Change From Baseline in Mean Diurnal Intra Ocular Pressure (IOP) in Study Eye at Day 14: Stage I — 25.97; 26.25; 25.90; 26.44 mmHg — p=0.028
Phase 4 N=1,137 A Study of LUMIGAN® RC in the Clinical Setting
Glaucoma, Primary Open Angle · Ocular Hypertension
Primary: Percentage of Treatment-Naive Patients With Ocular Hyperemia — 32.2; 39.8; 21.3; 5.9 Percentage of Patients
N/A N=7 Effect of Cosopt Versus Combigan on Retinal Vascular Autoregulation in Primary Open Angle Glaucoma (POAG)
Glaucoma
Primary: Presence of Retinal Vascular Dysregulation (RVD) — 7; 4 Participants
N/A N=358 An Observational Study of Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT) Who Switched IOP-lowering Treatments
Glaucoma, Open-Angle · Ocular Hypertension
Primary: Change From Baseline in Intraocular Pressure (IOP) in the Right Eye — -4.5 mmHg
Phase 4 N=800 A Safety and Efficacy Study of Bimatoprost 0.01% in Primary Open-Angle Glaucoma (POAG) or Ocular Hypertension (OH)
Glaucoma, Open-Angle · Ocular Hypertension
Primary: Severity of Ocular Hyperemia in the Study Eye on a 5-Point Scale — 40; 49; 20; 71 Participants
N/A N=10 Twenty-four Hour Intraocular Pressure Patterns in Patients With Uncontrolled Thyroid Eye Disease
Thyroid Eye Disease
Primary: Change in IOP Before and After Orbital Decompression Surgery — 18 mVEq (Sensismed Triggerfish output unit)
Phase 2 N=298 Study Assessing Safety and Efficacy of PG324 Ophthalmic Solution in Patients With Elevated Intraocular Pressure
Open Angle Glaucoma · Ocular Hypertension
Primary: Intraocular Pressure (IOP) — 25.11; 25.12; 25.35; 25.99 mmHg — p=<0.0001
Phase 3 N=1,636 Ocular Hypertension Treatment Study (OHTS)
Ocular Hypertension · Glaucoma
Primary: Incidence of Primary Open-Angle Glaucoma in Hypotensive Patients — 9.5; 4.4; 20.0; 14.1 percent of participants
N/A N=16 Effect of Travoprost 0.004% on Retinal Oximetry in Primary Open Angle Glaucoma
Primary Open Angle Glaucoma
Primary: Blood Oxygenation — 60; 60; 60 percentage of oxygenation
Phase 3 N=37 A Phase 3b Study Evaluating the 24-Hour Intraocular Pressure Lowering Effect of Bimatoprost SR in Patients With Open-Angle Glaucoma or Ocular Hypertension
Open-Angle Glaucoma · Ocular Hypertension
Primary: Change From Baseline in Time-Matched Intraocular Pressure (IOP) for Bimatoprost SR Treated Eyes — -3.7; -4.0; -2.5; -3.2 Millimeters of Mercury (mmHg)
N/A N=10 Intraocular Pressure During Abdominal Aortic Aneurysm (AAA) Repair
Problem With Vision Blindness · Intraocular Pressure · Ischemic Optic Neuropathy
Primary: Right Intraocular Pressure During Various Event Intervals in Open Abdominal Aortic Aneurysm Surgery. — 16.9; 13.8; 14.6; 13.5 mm Hg — p=<0.001
N/A N=67 The Impacts of Surgical Visibility Through Deep Neuromuscular Blockade on Intraocular Pressure in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy
Robot-Assisted Laparoscopic Radical Prostatectomy
Primary: Maximum Intraocular Pressure During RALRP Under Deep Neuromuscular Blockade — 23.3; 19.8 mmHg
Phase 4 N=263 A Study of Bimatoprost in the Treatment of Primary Open Angle Glaucoma and Ocular Hypertension
Glaucoma, Open-Angle · Ocular Hypertension
Primary: Intraocular Pressure (IOP) in the Study Eye — 16.5; 16.7; 15.7; 16.1 Millimeters of Mercury (mmHg)
Phase 4 N=260 Study of Rhopressa® for the Reduction of Elevated Intraocular Pressure in Patients With Glaucoma or Ocular Hypertension in a Real-world Setting
Glaucoma, Open-Angle · Ocular Hypertension
Primary: Intraocular Pressure (IOP) — -16.9; -2.3; 0.2; -17.0 percent change
N/A N=10 IOP Fluctuations in Patients With Sleep Apnea With or Without Primary Open Angle Glaucoma Using Positive Airway Pressure
Sleep Apnea, Obstructive · Primary Open-angle Glaucoma
Primary: Relationship Between IOP Fluctuation Pattern With or Without CPAP Therapy in Patients With Moderate to Severe OSAS With or Without POAG — 44.4; 42.2 mVEq/h
N/A N=2,580 A Study Comparing IOP-Lowering Treatments to Bimatoprost in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
Glaucoma, Open-Angle · Ocular Hypertension
Primary: Intraocular Pressure (IOP) at Baseline — 20.51; 20.65 Millimeters of Mercury (mmHg)
N/A N=312 A Study of Bimatoprost 0.01% in the Clinical Setting
Glaucoma, Primary Open Angle · Ocular Hypertension
Primary: Severity of Ocular Hyperemia in the Study Eye on a 5-Point Scale — 7; 36; 10; 50 Patients
Phase 2 N=5 Study of LL-BMT1 in Patients With Elevated Intraocular Pressure
Primary Open Angle Glaucoma · Ocular Hypertension
Primary: Adverse Event Rate — 1 Participants
Phase 4 N=22 Inhaled Corticosteroids: Effect on Intraocular Pressure in Patients With Controlled Glaucoma
Ocular Hypertension · Glaucoma, Open-Angle
Primary: Mean Intraocular Pressure — 14.7; 14.8 mmHg
Phase 3 N=144 A Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension
Glaucoma · Open-Angle Ocular Hypertension
Primary: Intraocular Pressure (IOP) at Baseline — 24.45; 24.38 millimeters of mercury (mmHg)
Phase 2 N=89 Safety and Efficacy of Daily CF101 Administered Orally in Subjects With Elevated Intraocular Pressure
Ocular Hypertension · Glaucoma
Primary: Intraocular Pressure in mmHg — 19.01; 19.84; 18.95 Intraocular Pressure in mmHg
Phase 4 N=52 Earlier Intraocular Pressure Control After Ahmed Glaucoma Valve Implantation for Glaucoma
Glaucoma
Primary: Rate of Hypertensive Phase After Ahmed Valve Implantation for Glaucoma — 9; 12 participants
N/A N=23 The Effects of the Water Drinking Test on Intraocular Pressure
Glaucoma
Primary: 24-hour IOP Patterns
N/A N=1,099 Safety and Efficacy Study of Bimatoprost, Latanoprost, and Travoprost in Patients With Elevated Intraocular Pressure (IOP) and Open-angle Glaucoma (OAG)
Open-Angle Glaucoma · Ocular Hypertension
Primary: Change From Baseline in Bilateral Intraocular Pressure (IOP) at One Year — 20.8; 20.3; 20.6; -4.8 Millimeters of mercury (mmHg)